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Genetics of osteoarthritis.
Curr Rheumatol Rep. 2004 Feb; 6(1):7-13.CR

Abstract

Osteoarthritis (OA) is a major cause of morbidity, physical limitation, and health care use, including total joint arthroplasty. That OA has a genetic component has been known for some time, but only recently has formal study of this occurred. Twin studies, segregation analyses, linkage analyses, and candidate gene association studies have generated important information about inheritance patterns and the location in the genome of potentially causative mutations. Results across studies are not always concordant, however; this is likely the result of variations in study populations, disease definitions, evaluation of control subjects, and statistical analysis. Although the genetics of OA is complex and not completely understood, there is cause for optimism as rapidly improving technologies make the quest for the genes responsible for OA increasingly within reach. Family history of OA and joint replacement for OA should be assessed in the context of other potentially modifiable risk factors to attempt to alter patient outcome.

Authors+Show Affiliations

Jordan JM
Thurston Arthritis Research Center, University of North Carolina, 3310 Doc. J. Thurston, Jr. Building, CB # 7330, Chapel Hill, NC 27599, USA. joanne_jordan@med.unc.edu
Kraus VB
No affiliation info available
Hochberg MC
No affiliation info available

MeSH

Biomedical ResearchChromosome MappingGenetic LinkageHumansOsteoarthritisPedigreeProtein Array AnalysisTwin Studies as Topic

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

14713397

Citation

Jordan, Joanne M., et al. "Genetics of Osteoarthritis." Current Rheumatology Reports, vol. 6, no. 1, 2004, pp. 7-13.
Jordan JM, Kraus VB, Hochberg MC. Genetics of osteoarthritis. Curr Rheumatol Rep. 2004;6(1):7-13.
Jordan, J. M., Kraus, V. B., & Hochberg, M. C. (2004). Genetics of osteoarthritis. Current Rheumatology Reports, 6(1), 7-13.
Jordan JM, Kraus VB, Hochberg MC. Genetics of Osteoarthritis. Curr Rheumatol Rep. 2004;6(1):7-13. PubMed PMID: 14713397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetics of osteoarthritis. AU - Jordan,Joanne M, AU - Kraus,Virginia B, AU - Hochberg,Marc C, PY - 2004/1/10/pubmed PY - 2004/4/27/medline PY - 2004/1/10/entrez SP - 7 EP - 13 JF - Current rheumatology reports JO - Curr Rheumatol Rep VL - 6 IS - 1 N2 - Osteoarthritis (OA) is a major cause of morbidity, physical limitation, and health care use, including total joint arthroplasty. That OA has a genetic component has been known for some time, but only recently has formal study of this occurred. Twin studies, segregation analyses, linkage analyses, and candidate gene association studies have generated important information about inheritance patterns and the location in the genome of potentially causative mutations. Results across studies are not always concordant, however; this is likely the result of variations in study populations, disease definitions, evaluation of control subjects, and statistical analysis. Although the genetics of OA is complex and not completely understood, there is cause for optimism as rapidly improving technologies make the quest for the genes responsible for OA increasingly within reach. Family history of OA and joint replacement for OA should be assessed in the context of other potentially modifiable risk factors to attempt to alter patient outcome. SN - 1523-3774 UR - https://www.unboundmedicine.com/medline/citation/14713397/Genetics_of_osteoarthritis_ DB - PRIME DP - Unbound Medicine ER -