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Association between asthma and rhinitis according to atopic sensitization in a population-based study.
J Allergy Clin Immunol. 2004 Jan; 113(1):86-93.JA

Abstract

BACKGROUND

Although asthma and rhinitis often occur together, the reason for this common comorbidity is still a matter of debate.

OBJECTIVE

We sought to assess whether the coexistence of asthma and rhinitis could be explained by common risk factors.

METHODS

International cross-sectional study of representative samples of young adults, who completed a detailed questionnaire and underwent lung function tests, bronchoprovocation challenge, IgE measurements, and skin prick tests.

RESULTS

In all countries, asthma and bronchial hyperreactivity were more frequent in subjects with rhinitis than in those without (odds ratio [OR], 6.63; 95% CI, 5.44-8.08; and OR, 3.02 95% CI, 2.66-3.43, respectively). Seventy-four percent to 81% of subjects with asthma reported rhinitis, depending on sensitization to specific allergens. Conversely, the risk of asthma increased from 2.0% in subjects without rhinitis to 6.7% in subjects with rhinitis only when exposed to pollen, 11.9% in subjects with rhinitis when exposed to animals, and 18.8% in subjects with rhinitis either when exposed to pollen or to animals. The association between rhinitis and asthma remained significant after adjustment for total IgE, parental history of asthma, and allergen sensitization (OR, 3.41; 95% CI, 2.75-4.2 suggesting that the coexistence of asthma and rhinitis is not solely due to atopic predisposition to these 2 diseases.

CONCLUSIONS

Although there were some variations in the association between asthma and rhinitis according to sensitization to individual allergens, the strong association between asthma and rhinitis was not fully explained by shared risk factors, including atopy. Our findings are consistent with the hypothesis that rhinitis might increase the risk of asthma.

Authors+Show Affiliations

Inserm Unité 408, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14713912

Citation

Leynaert, Bénédicte, et al. "Association Between Asthma and Rhinitis According to Atopic Sensitization in a Population-based Study." The Journal of Allergy and Clinical Immunology, vol. 113, no. 1, 2004, pp. 86-93.
Leynaert B, Neukirch C, Kony S, et al. Association between asthma and rhinitis according to atopic sensitization in a population-based study. J Allergy Clin Immunol. 2004;113(1):86-93.
Leynaert, B., Neukirch, C., Kony, S., Guénégou, A., Bousquet, J., Aubier, M., & Neukirch, F. (2004). Association between asthma and rhinitis according to atopic sensitization in a population-based study. The Journal of Allergy and Clinical Immunology, 113(1), 86-93.
Leynaert B, et al. Association Between Asthma and Rhinitis According to Atopic Sensitization in a Population-based Study. J Allergy Clin Immunol. 2004;113(1):86-93. PubMed PMID: 14713912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between asthma and rhinitis according to atopic sensitization in a population-based study. AU - Leynaert,Bénédicte, AU - Neukirch,Catherine, AU - Kony,Sabine, AU - Guénégou,Armelle, AU - Bousquet,Jean, AU - Aubier,Michel, AU - Neukirch,Françoise, PY - 2004/1/10/pubmed PY - 2004/2/18/medline PY - 2004/1/10/entrez SP - 86 EP - 93 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 113 IS - 1 N2 - BACKGROUND: Although asthma and rhinitis often occur together, the reason for this common comorbidity is still a matter of debate. OBJECTIVE: We sought to assess whether the coexistence of asthma and rhinitis could be explained by common risk factors. METHODS: International cross-sectional study of representative samples of young adults, who completed a detailed questionnaire and underwent lung function tests, bronchoprovocation challenge, IgE measurements, and skin prick tests. RESULTS: In all countries, asthma and bronchial hyperreactivity were more frequent in subjects with rhinitis than in those without (odds ratio [OR], 6.63; 95% CI, 5.44-8.08; and OR, 3.02 95% CI, 2.66-3.43, respectively). Seventy-four percent to 81% of subjects with asthma reported rhinitis, depending on sensitization to specific allergens. Conversely, the risk of asthma increased from 2.0% in subjects without rhinitis to 6.7% in subjects with rhinitis only when exposed to pollen, 11.9% in subjects with rhinitis when exposed to animals, and 18.8% in subjects with rhinitis either when exposed to pollen or to animals. The association between rhinitis and asthma remained significant after adjustment for total IgE, parental history of asthma, and allergen sensitization (OR, 3.41; 95% CI, 2.75-4.2 suggesting that the coexistence of asthma and rhinitis is not solely due to atopic predisposition to these 2 diseases. CONCLUSIONS: Although there were some variations in the association between asthma and rhinitis according to sensitization to individual allergens, the strong association between asthma and rhinitis was not fully explained by shared risk factors, including atopy. Our findings are consistent with the hypothesis that rhinitis might increase the risk of asthma. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/14713912/Association_between_asthma_and_rhinitis_according_to_atopic_sensitization_in_a_population_based_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674903024473 DB - PRIME DP - Unbound Medicine ER -