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Secretory activity of mast cell during stress: effect of prolyl-glycyl-proline and Semax.
Bull Exp Biol Med. 2003 Oct; 136(4):325-7.BE

Abstract

Stress increased secretory activity of mast cells in the mesentery and subcutaneous fat of rats. Intraperitoneal injection of Semax and prolyl-glycyl-proline in doses of 0.05 and 1 mg/kg, respectively, 1 h before stress abolished this effect. The test preparations did not modulate secretory activity of mast cells in unstressed animals. Semax and prolyl-glycyl-proline in vitro prevented activation of mast cells with synacten and acetylcholine. The stabilizing effect of peptides on mast cells probably determines their antiulcer activity.

Authors+Show Affiliations

Umarova BA
Department of Human and Animal Physiology, Biological Faculty, M V Lomonosov Moscow State University.
Kopylova GN
No affiliation info available
Smirnova EA
No affiliation info available
Guseva AA
No affiliation info available
Zhuikova SE
No affiliation info available

MeSH

AcetylcholineAdrenocorticotropic HormoneAnimalsAnimals, Outbred StrainsDisease Models, AnimalInjections, IntraperitonealMaleMast CellsMesenteryOligopeptidesPeptide FragmentsProlineRatsStress, Psychological

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14714073

Citation

Umarova, B A., et al. "Secretory Activity of Mast Cell During Stress: Effect of Prolyl-glycyl-proline and Semax." Bulletin of Experimental Biology and Medicine, vol. 136, no. 4, 2003, pp. 325-7.
Umarova BA, Kopylova GN, Smirnova EA, et al. Secretory activity of mast cell during stress: effect of prolyl-glycyl-proline and Semax. Bull Exp Biol Med. 2003;136(4):325-7.
Umarova, B. A., Kopylova, G. N., Smirnova, E. A., Guseva, A. A., & Zhuikova, S. E. (2003). Secretory activity of mast cell during stress: effect of prolyl-glycyl-proline and Semax. Bulletin of Experimental Biology and Medicine, 136(4), 325-7.
Umarova BA, et al. Secretory Activity of Mast Cell During Stress: Effect of Prolyl-glycyl-proline and Semax. Bull Exp Biol Med. 2003;136(4):325-7. PubMed PMID: 14714073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Secretory activity of mast cell during stress: effect of prolyl-glycyl-proline and Semax. AU - Umarova,B A, AU - Kopylova,G N, AU - Smirnova,E A, AU - Guseva,A A, AU - Zhuikova,S E, PY - 2004/1/10/pubmed PY - 2004/12/16/medline PY - 2004/1/10/entrez SP - 325 EP - 7 JF - Bulletin of experimental biology and medicine JO - Bull Exp Biol Med VL - 136 IS - 4 N2 - Stress increased secretory activity of mast cells in the mesentery and subcutaneous fat of rats. Intraperitoneal injection of Semax and prolyl-glycyl-proline in doses of 0.05 and 1 mg/kg, respectively, 1 h before stress abolished this effect. The test preparations did not modulate secretory activity of mast cells in unstressed animals. Semax and prolyl-glycyl-proline in vitro prevented activation of mast cells with synacten and acetylcholine. The stabilizing effect of peptides on mast cells probably determines their antiulcer activity. SN - 0007-4888 UR - https://www.unboundmedicine.com/medline/citation/14714073/Secretory_activity_of_mast_cell_during_stress:_effect_of_prolyl_glycyl_proline_and_Semax_ DB - PRIME DP - Unbound Medicine ER -