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Stones associated renal pelvic malignancies.
Indian J Cancer. 2003 Jul-Sep; 40(3):108-12.IJ

Abstract

BACKGROUND

The clinico-pathological characteristics of renal pelvic malignancies associated with stones were retrospectively analyzed.

AIMS

The main objective was to define the biological behavior and prognostic factors for these malignancies.

SETTINGS & DESIGN

The tumors were classified according to the pathological types. The clinical data, imaging features and pathological features were analyzed with relation to prognosis.

MATERIAL AND METHODS

Eighteen cases of malignancies associated with stone disease were retrospectively studied. The institute review board permitted the study.

RESULTS

High incidence (15/18) of squamous cell carcinoma (SCC) was noted. The prognosis in this group of patients was uniformly poor. The median survival time was 3.6 months in the SCC group, 7.5 months in the Transitional Cell Carcinoma (TCC) group and 24 months in the Adenocarcinoma (AC) group. Infectious and systemic symptoms were noted in the majority of the patients. Preoperative Imaging techniques revealed tumor in only 2 cases. Both underwent radical extirpation and the median survival is 18 months till date. In the other 16 patients, where the initial diagnosis was made only on histological analysis of incomplete nephrectomy specimens, the survival was 3.56 months. All patients had prolonged history of staghorn stone disease with associated non-functioning kidney. We found that the main prognostic factor was the stage of the disease.

CONCLUSIONS

Malignancies associated with stone disease have insidious onset of clinical symptoms and need a high degree of suspicion to identify them pre-operatively. The grave prognosis associated with incomplete excision makes it imperative to diagnose them earlier.

Authors+Show Affiliations

Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareli Road, Lucknow - 226 014, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

14716114

Citation

Raghavendran, M, et al. "Stones Associated Renal Pelvic Malignancies." Indian Journal of Cancer, vol. 40, no. 3, 2003, pp. 108-12.
Raghavendran M, Rastogi A, Dubey D, et al. Stones associated renal pelvic malignancies. Indian J Cancer. 2003;40(3):108-12.
Raghavendran, M., Rastogi, A., Dubey, D., Chaudhary, H., Kumar, A., Srivastava, A., Mandhani, A., Krishnani, N., & Kapoor, R. (2003). Stones associated renal pelvic malignancies. Indian Journal of Cancer, 40(3), 108-12.
Raghavendran M, et al. Stones Associated Renal Pelvic Malignancies. Indian J Cancer. 2003 Jul-Sep;40(3):108-12. PubMed PMID: 14716114.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stones associated renal pelvic malignancies. AU - Raghavendran,M, AU - Rastogi,A, AU - Dubey,D, AU - Chaudhary,H, AU - Kumar,A, AU - Srivastava,A, AU - Mandhani,A, AU - Krishnani,N, AU - Kapoor,R, PY - 2004/1/13/pubmed PY - 2004/3/6/medline PY - 2004/1/13/entrez SP - 108 EP - 12 JF - Indian journal of cancer JO - Indian J Cancer VL - 40 IS - 3 N2 - BACKGROUND: The clinico-pathological characteristics of renal pelvic malignancies associated with stones were retrospectively analyzed. AIMS: The main objective was to define the biological behavior and prognostic factors for these malignancies. SETTINGS & DESIGN: The tumors were classified according to the pathological types. The clinical data, imaging features and pathological features were analyzed with relation to prognosis. MATERIAL AND METHODS: Eighteen cases of malignancies associated with stone disease were retrospectively studied. The institute review board permitted the study. RESULTS: High incidence (15/18) of squamous cell carcinoma (SCC) was noted. The prognosis in this group of patients was uniformly poor. The median survival time was 3.6 months in the SCC group, 7.5 months in the Transitional Cell Carcinoma (TCC) group and 24 months in the Adenocarcinoma (AC) group. Infectious and systemic symptoms were noted in the majority of the patients. Preoperative Imaging techniques revealed tumor in only 2 cases. Both underwent radical extirpation and the median survival is 18 months till date. In the other 16 patients, where the initial diagnosis was made only on histological analysis of incomplete nephrectomy specimens, the survival was 3.56 months. All patients had prolonged history of staghorn stone disease with associated non-functioning kidney. We found that the main prognostic factor was the stage of the disease. CONCLUSIONS: Malignancies associated with stone disease have insidious onset of clinical symptoms and need a high degree of suspicion to identify them pre-operatively. The grave prognosis associated with incomplete excision makes it imperative to diagnose them earlier. SN - 0019-509X UR - https://www.unboundmedicine.com/medline/citation/14716114/Stones_associated_renal_pelvic_malignancies_ L2 - http://www.indianjcancer.com/article.asp?issn=0019-509X;year=2003;volume=40;issue=3;spage=108;epage=112;aulast=Raghavendran DB - PRIME DP - Unbound Medicine ER -