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Open-angle glaucoma and systemic thyroid disease in an older population: The Blue Mountains Eye Study.
Eye (Lond) 2004; 18(6):600-8E

Abstract

PURPOSE

To assess whether thyroid disease is independently associated with open-angle glaucoma (OAG), using history of thyroid disease and current thyroxine use.

METHODS

The Blue Mountains Eye Study examined 3654 persons, aged 49-97 years. Interviewers collected self-reported history of diagnosis and treatment for thyroid disease. Eye examinations included applanation tonometry, stereoscopic optic disc photography and automated perimetry. OAG was diagnosed from the presence of matching typical glaucomatous field changes and optic disc cupping, independent of intraocular pressure. Associations between thyroid disease (history and treatment) and OAG were assessed in a multivariate model.

RESULTS

Of 324 participants (8.9%) reporting history of thyroid disease, 147 (4.0%) were currently using thyroxine. Although we could not accurately categorize the thyroid disorder for all cases, current use of thyroxine suggests a prior hypothyroid state. All thyroid disease subgroups affected women more frequently than men, P=0.001. OAG was diagnosed in 108 subjects (3.0%) and was more frequent in those reporting past thyroid disease (4.6 vs 2.8%). This relationship was not statistically significant after adjusting for potential confounders, multivariate odds ratio (OR) 1.6; 95% confidence interval (95% CI) 0.9-2.9. OAG was significantly more frequent, however, in subjects reporting current thyroxine use (6.8 vs 2.8%), multivariate OR 2.1; 95% CI 1.0-4.4, or history of thyroid surgery (6.5 vs 2.8%), multivariate OR 2.5; 95% CI 1.0-6.2.

CONCLUSIONS

This population-based study suggests that thyroid disease, indicated by current thyroxine use or past thyroid surgery, could be independently related to OAG.

Authors+Show Affiliations

Department of Ophthalmology, University of Sydney, Sydney, NSW, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14716330

Citation

Lee, A J., et al. "Open-angle Glaucoma and Systemic Thyroid Disease in an Older Population: the Blue Mountains Eye Study." Eye (London, England), vol. 18, no. 6, 2004, pp. 600-8.
Lee AJ, Rochtchina E, Wang JJ, et al. Open-angle glaucoma and systemic thyroid disease in an older population: The Blue Mountains Eye Study. Eye (Lond). 2004;18(6):600-8.
Lee, A. J., Rochtchina, E., Wang, J. J., Healey, P. R., & Mitchell, P. (2004). Open-angle glaucoma and systemic thyroid disease in an older population: The Blue Mountains Eye Study. Eye (London, England), 18(6), pp. 600-8.
Lee AJ, et al. Open-angle Glaucoma and Systemic Thyroid Disease in an Older Population: the Blue Mountains Eye Study. Eye (Lond). 2004;18(6):600-8. PubMed PMID: 14716330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Open-angle glaucoma and systemic thyroid disease in an older population: The Blue Mountains Eye Study. AU - Lee,A J, AU - Rochtchina,E, AU - Wang,J J, AU - Healey,P R, AU - Mitchell,P, PY - 2004/1/13/pubmed PY - 2004/9/28/medline PY - 2004/1/13/entrez SP - 600 EP - 8 JF - Eye (London, England) JO - Eye (Lond) VL - 18 IS - 6 N2 - PURPOSE: To assess whether thyroid disease is independently associated with open-angle glaucoma (OAG), using history of thyroid disease and current thyroxine use. METHODS: The Blue Mountains Eye Study examined 3654 persons, aged 49-97 years. Interviewers collected self-reported history of diagnosis and treatment for thyroid disease. Eye examinations included applanation tonometry, stereoscopic optic disc photography and automated perimetry. OAG was diagnosed from the presence of matching typical glaucomatous field changes and optic disc cupping, independent of intraocular pressure. Associations between thyroid disease (history and treatment) and OAG were assessed in a multivariate model. RESULTS: Of 324 participants (8.9%) reporting history of thyroid disease, 147 (4.0%) were currently using thyroxine. Although we could not accurately categorize the thyroid disorder for all cases, current use of thyroxine suggests a prior hypothyroid state. All thyroid disease subgroups affected women more frequently than men, P=0.001. OAG was diagnosed in 108 subjects (3.0%) and was more frequent in those reporting past thyroid disease (4.6 vs 2.8%). This relationship was not statistically significant after adjusting for potential confounders, multivariate odds ratio (OR) 1.6; 95% confidence interval (95% CI) 0.9-2.9. OAG was significantly more frequent, however, in subjects reporting current thyroxine use (6.8 vs 2.8%), multivariate OR 2.1; 95% CI 1.0-4.4, or history of thyroid surgery (6.5 vs 2.8%), multivariate OR 2.5; 95% CI 1.0-6.2. CONCLUSIONS: This population-based study suggests that thyroid disease, indicated by current thyroxine use or past thyroid surgery, could be independently related to OAG. SN - 0950-222X UR - https://www.unboundmedicine.com/medline/citation/14716330/Open_angle_glaucoma_and_systemic_thyroid_disease_in_an_older_population:_The_Blue_Mountains_Eye_Study_ L2 - http://dx.doi.org/10.1038/sj.eye.6700731 DB - PRIME DP - Unbound Medicine ER -