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Effect of glucose on tobacco withdrawal symptoms in recent quitters using bupropion or nicotine replacement.
Hum Psychopharmacol 2004; 19(1):57-61HP

Abstract

RATIONALE AND OBJECTIVES

Glucose has been shown to alleviate the desire to smoke in abstaining heavy smokers and to increase 1-month abstinence rates on its own as well as when combined with nicotine patches. It is not known whether a single dose of glucose can provide additional withdrawal relief in patients who have already abstained for a period of time, and whether it can assist patients using bupropion.

METHODS

Seventy-five volunteers from a smoking cessation clinic who maintained 1 week of validated continuous abstinence were randomized to receive four 3 mg dextrose or placebo (sorbitol) tablets. There were 31 bupropion and 44 NRT users. Measures of desire to smoke and of five withdrawal symptoms were taken before taking the tablets, and then at 5 min intervals for 20 min.

RESULTS

Despite low baseline ratings of withdrawal discomfort, glucose tablets significantly reduced irritability and hunger in bupropion users. Two other effects including reduction in composite withdrawal score approached but did not reach statistical significance. The effects emerged 10-15 min after taking the tablets. No glucose effect was detected in patients using NRT.

CONCLUSIONS

A single dose of glucose taken after a week of sustained abstinence may reduce withdrawal discomfort in patients on bupropion. Further research is warranted in combining glucose and bupropion, and in opportunistic use of glucose tablets in tempting situations during a smoking cessation attempt.

Authors+Show Affiliations

Tobacco Dependence Research and Treatment Centre, Institute of Community Health Sciences, Barts and The London, Queen Mary's School of Medicine and Dentistry, University of London, Turner Street, London E1 2AD, UK. h.j.mcrobbie@qmul.ac.ukNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

14716714

Citation

McRobbie, Hayden, and Peter Hajek. "Effect of Glucose On Tobacco Withdrawal Symptoms in Recent Quitters Using Bupropion or Nicotine Replacement." Human Psychopharmacology, vol. 19, no. 1, 2004, pp. 57-61.
McRobbie H, Hajek P. Effect of glucose on tobacco withdrawal symptoms in recent quitters using bupropion or nicotine replacement. Hum Psychopharmacol. 2004;19(1):57-61.
McRobbie, H., & Hajek, P. (2004). Effect of glucose on tobacco withdrawal symptoms in recent quitters using bupropion or nicotine replacement. Human Psychopharmacology, 19(1), pp. 57-61.
McRobbie H, Hajek P. Effect of Glucose On Tobacco Withdrawal Symptoms in Recent Quitters Using Bupropion or Nicotine Replacement. Hum Psychopharmacol. 2004;19(1):57-61. PubMed PMID: 14716714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of glucose on tobacco withdrawal symptoms in recent quitters using bupropion or nicotine replacement. AU - McRobbie,Hayden, AU - Hajek,Peter, PY - 2004/1/13/pubmed PY - 2004/6/26/medline PY - 2004/1/13/entrez SP - 57 EP - 61 JF - Human psychopharmacology JO - Hum Psychopharmacol VL - 19 IS - 1 N2 - RATIONALE AND OBJECTIVES: Glucose has been shown to alleviate the desire to smoke in abstaining heavy smokers and to increase 1-month abstinence rates on its own as well as when combined with nicotine patches. It is not known whether a single dose of glucose can provide additional withdrawal relief in patients who have already abstained for a period of time, and whether it can assist patients using bupropion. METHODS: Seventy-five volunteers from a smoking cessation clinic who maintained 1 week of validated continuous abstinence were randomized to receive four 3 mg dextrose or placebo (sorbitol) tablets. There were 31 bupropion and 44 NRT users. Measures of desire to smoke and of five withdrawal symptoms were taken before taking the tablets, and then at 5 min intervals for 20 min. RESULTS: Despite low baseline ratings of withdrawal discomfort, glucose tablets significantly reduced irritability and hunger in bupropion users. Two other effects including reduction in composite withdrawal score approached but did not reach statistical significance. The effects emerged 10-15 min after taking the tablets. No glucose effect was detected in patients using NRT. CONCLUSIONS: A single dose of glucose taken after a week of sustained abstinence may reduce withdrawal discomfort in patients on bupropion. Further research is warranted in combining glucose and bupropion, and in opportunistic use of glucose tablets in tempting situations during a smoking cessation attempt. SN - 0885-6222 UR - https://www.unboundmedicine.com/medline/citation/14716714/Effect_of_glucose_on_tobacco_withdrawal_symptoms_in_recent_quitters_using_bupropion_or_nicotine_replacement_ L2 - https://doi.org/10.1002/hup.535 DB - PRIME DP - Unbound Medicine ER -