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In vitro antimicrobial activity of propolis and synergism between propolis and antimicrobial drugs.

Abstract

The aim of this study was to investigate antimicrobial properties of ethanolic extract of 13 propolis (EEP) samples from different regions of Serbia against 39 microorganisms (14 resistant or multiresistant to antibiotics), and to determine synergistic activity between antimicrobials and propolis. Antimicrobial activity of propolis samples was evaluated by agar diffusion and agar dilution method. The synergistic action of propolis with antimicrobial drugs was assayed by the disc diffusion method on agar containing subinhibitory concentrations of propolis. Obtained results indicate that EEP, irrespectively of microbial resistance to antibiotics, showed significant antimicrobial activities against Gram-positive bacteria (MIC 0.078%-1.25% of EEP) and yeasts (0.16%-1.25%), while Gram-negative bacteria were less susceptible (1.25%-->5%). Enterococcus faecalis was the most resistant Gram-positive bacterium, Salmonella spp. the most resistant Gram-negative bacteria, and Candida albicans the most resistant yeast. EEP showed synergism with selected antibiotics, and displayed ability to enhance the activities of antifungals. The shown antimicrobial potential of propolis alone or in combination with certain antibiotics and antifungals is of potential medical interest.

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  • Authors+Show Affiliations

    ,

    Department of Bacteriology, Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, Dr Subotića 1, 11000 Belgrade, Serbia. stepan@afrodita.rcub.bg.ac.yu

    , ,

    Source

    Microbiological research 158:4 2003 pg 353-7

    MeSH

    Anti-Bacterial Agents
    Anti-Infective Agents
    Candida
    Drug Resistance, Bacterial
    Drug Synergism
    Gram-Negative Bacteria
    Gram-Positive Bacteria
    Humans
    Microbial Sensitivity Tests
    Propolis

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    14717457

    Citation

    Stepanović, Srdjan, et al. "In Vitro Antimicrobial Activity of Propolis and Synergism Between Propolis and Antimicrobial Drugs." Microbiological Research, vol. 158, no. 4, 2003, pp. 353-7.
    Stepanović S, Antić N, Dakić I, et al. In vitro antimicrobial activity of propolis and synergism between propolis and antimicrobial drugs. Microbiol Res. 2003;158(4):353-7.
    Stepanović, S., Antić, N., Dakić, I., & Svabić-Vlahović, M. (2003). In vitro antimicrobial activity of propolis and synergism between propolis and antimicrobial drugs. Microbiological Research, 158(4), pp. 353-7.
    Stepanović S, et al. In Vitro Antimicrobial Activity of Propolis and Synergism Between Propolis and Antimicrobial Drugs. Microbiol Res. 2003;158(4):353-7. PubMed PMID: 14717457.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - In vitro antimicrobial activity of propolis and synergism between propolis and antimicrobial drugs. AU - Stepanović,Srdjan, AU - Antić,Natasa, AU - Dakić,Ivana, AU - Svabić-Vlahović,Milena, PY - 2004/1/14/pubmed PY - 2004/2/26/medline PY - 2004/1/14/entrez SP - 353 EP - 7 JF - Microbiological research JO - Microbiol. Res. VL - 158 IS - 4 N2 - The aim of this study was to investigate antimicrobial properties of ethanolic extract of 13 propolis (EEP) samples from different regions of Serbia against 39 microorganisms (14 resistant or multiresistant to antibiotics), and to determine synergistic activity between antimicrobials and propolis. Antimicrobial activity of propolis samples was evaluated by agar diffusion and agar dilution method. The synergistic action of propolis with antimicrobial drugs was assayed by the disc diffusion method on agar containing subinhibitory concentrations of propolis. Obtained results indicate that EEP, irrespectively of microbial resistance to antibiotics, showed significant antimicrobial activities against Gram-positive bacteria (MIC 0.078%-1.25% of EEP) and yeasts (0.16%-1.25%), while Gram-negative bacteria were less susceptible (1.25%-->5%). Enterococcus faecalis was the most resistant Gram-positive bacterium, Salmonella spp. the most resistant Gram-negative bacteria, and Candida albicans the most resistant yeast. EEP showed synergism with selected antibiotics, and displayed ability to enhance the activities of antifungals. The shown antimicrobial potential of propolis alone or in combination with certain antibiotics and antifungals is of potential medical interest. SN - 0944-5013 UR - https://www.unboundmedicine.com/medline/citation/14717457/In_vitro_antimicrobial_activity_of_propolis_and_synergism_between_propolis_and_antimicrobial_drugs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-5013(04)70139-1 DB - PRIME DP - Unbound Medicine ER -