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Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy.
Acta Neuropathol. 2004 Apr; 107(4):292-8.AN

Abstract

We immunohistochemically examined the brain and peripheral sympathetic ganglia from eight patients with multiple system atrophy (MSA), using an antibody specific for phosphorylated alpha-synuclein (anti-PSer129). Phosphorylated alpha-synuclein was deposited in five cellular locations: oligodendroglial cytoplasm and nucleus, and neuronal cytoplasm, processes and nucleus. Many neuronal cytoplasmic inclusions (NCIs) were found in the pontine and inferior olivary nuclei and, to a lesser extent, in the substantia nigra, locus ceruleus, and neocortical and hippocampal neurons. NCIs were also found in the sympathetic ganglia in two out of the eight cases. Moreover, anti-PSer129 immunohistochemistry revealed extensive neuropil pathology; swollen neurites were abundant in the pontine nucleus, delicate neurites were observed in the deeper layers of the cerebral cortex and thalamus, and neuropil threads and dot-like structures were distributed in the basal ganglia and brainstem. Diffuse neuronal cytoplasmic staining (pre-NCI) was frequently found in the pontine and inferior olivary nuclei. Thus, the widespread accumulation of phosphorylated alpha-synuclein in both glial and neuronal cells is a pathological feature in patients suffering from MSA.

Authors+Show Affiliations

Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu-cho, 036-8562, Hirosaki, Japan. nishie@cc.hirosaki-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14722716

Citation

Nishie, Makoto, et al. "Accumulation of Phosphorylated Alpha-synuclein in the Brain and Peripheral Ganglia of Patients With Multiple System Atrophy." Acta Neuropathologica, vol. 107, no. 4, 2004, pp. 292-8.
Nishie M, Mori F, Fujiwara H, et al. Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy. Acta Neuropathol. 2004;107(4):292-8.
Nishie, M., Mori, F., Fujiwara, H., Hasegawa, M., Yoshimoto, M., Iwatsubo, T., Takahashi, H., & Wakabayashi, K. (2004). Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy. Acta Neuropathologica, 107(4), 292-8.
Nishie M, et al. Accumulation of Phosphorylated Alpha-synuclein in the Brain and Peripheral Ganglia of Patients With Multiple System Atrophy. Acta Neuropathol. 2004;107(4):292-8. PubMed PMID: 14722716.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy. AU - Nishie,Makoto, AU - Mori,Fumiaki, AU - Fujiwara,Hideo, AU - Hasegawa,Masato, AU - Yoshimoto,Makoto, AU - Iwatsubo,Takeshi, AU - Takahashi,Hitoshi, AU - Wakabayashi,Koichi, Y1 - 2004/01/14/ PY - 2003/09/11/received PY - 2003/12/01/revised PY - 2003/12/01/accepted PY - 2004/1/15/pubmed PY - 2004/5/25/medline PY - 2004/1/15/entrez SP - 292 EP - 8 JF - Acta neuropathologica JO - Acta Neuropathol VL - 107 IS - 4 N2 - We immunohistochemically examined the brain and peripheral sympathetic ganglia from eight patients with multiple system atrophy (MSA), using an antibody specific for phosphorylated alpha-synuclein (anti-PSer129). Phosphorylated alpha-synuclein was deposited in five cellular locations: oligodendroglial cytoplasm and nucleus, and neuronal cytoplasm, processes and nucleus. Many neuronal cytoplasmic inclusions (NCIs) were found in the pontine and inferior olivary nuclei and, to a lesser extent, in the substantia nigra, locus ceruleus, and neocortical and hippocampal neurons. NCIs were also found in the sympathetic ganglia in two out of the eight cases. Moreover, anti-PSer129 immunohistochemistry revealed extensive neuropil pathology; swollen neurites were abundant in the pontine nucleus, delicate neurites were observed in the deeper layers of the cerebral cortex and thalamus, and neuropil threads and dot-like structures were distributed in the basal ganglia and brainstem. Diffuse neuronal cytoplasmic staining (pre-NCI) was frequently found in the pontine and inferior olivary nuclei. Thus, the widespread accumulation of phosphorylated alpha-synuclein in both glial and neuronal cells is a pathological feature in patients suffering from MSA. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/14722716/Accumulation_of_phosphorylated_alpha_synuclein_in_the_brain_and_peripheral_ganglia_of_patients_with_multiple_system_atrophy_ L2 - https://dx.doi.org/10.1007/s00401-003-0811-1 DB - PRIME DP - Unbound Medicine ER -