Tags

Type your tag names separated by a space and hit enter

Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles.
J Infect Dis. 2004 Jan 15; 189(2):221-32.JI

Abstract

A prospective study of clinical and cytokine profiles of 107 infants with dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) was conducted. Fever, petechiae on the skin, and hepatomegaly were the most common clinical findings associated with DHF/DSS in infants. DSS occurred in 20.5% of the patients. Hemoconcentration and thrombocytopenia were observed in 91.5% and 92.5% of the patients, respectively. Serologic testing revealed that almost all of the patients (95.3%) had primary dengue virus infections. These data demonstrate that clinical and laboratory findings of DHF/DSS in infants are compatible with the World Health Organization's clinical diagnostic criteria for pediatric DHF. The present study is the first to report evidence of production of cytokines in infants with DHF/DSS and to describe the difference between the cytokine profile of infants with primary dengue virus infections and children with secondary infections. Overproduction of both proinflammatory cytokines (interferon-gamma and tumor necrosis factor-alpha) and anti-inflammatory cytokines (interleukin-10 and -6) may play a role in the pathogenesis of DHF/DSS in infants.

Authors+Show Affiliations

Department of Dengue Hemorrhagic Fever, Children's Hospital No. 1-Ho Chi Minh City, Vietnam. hungdhf@hcm.fpt.vnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14722886

Citation

Nguyen, Thanh Hung, et al. "Dengue Hemorrhagic Fever in Infants: a Study of Clinical and Cytokine Profiles." The Journal of Infectious Diseases, vol. 189, no. 2, 2004, pp. 221-32.
Nguyen TH, Lei HY, Nguyen TL, et al. Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles. J Infect Dis. 2004;189(2):221-32.
Nguyen, T. H., Lei, H. Y., Nguyen, T. L., Lin, Y. S., Huang, K. J., Le, B. L., Lin, C. F., Yeh, T. M., Do, Q. H., Vu, T. Q., Chen, L. C., Huang, J. H., Lam, T. M., Liu, C. C., & Halstead, S. B. (2004). Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles. The Journal of Infectious Diseases, 189(2), 221-32.
Nguyen TH, et al. Dengue Hemorrhagic Fever in Infants: a Study of Clinical and Cytokine Profiles. J Infect Dis. 2004 Jan 15;189(2):221-32. PubMed PMID: 14722886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles. AU - Nguyen,Thanh Hung, AU - Lei,Huan-Yao, AU - Nguyen,Trong Lan, AU - Lin,Yee-Shin, AU - Huang,Kao-Jean, AU - Le,Bich Lien, AU - Lin,Chiou-Feng, AU - Yeh,Trai-Ming, AU - Do,Quang Ha, AU - Vu,Thi Que Huong, AU - Chen,Lien-Cheng, AU - Huang,Jyh-Hsiung, AU - Lam,Thi My, AU - Liu,Ching-Chuan, AU - Halstead,Scott B, Y1 - 2004/01/09/ PY - 2003/04/01/received PY - 2003/07/16/accepted PY - 2004/1/15/pubmed PY - 2004/2/21/medline PY - 2004/1/15/entrez SP - 221 EP - 32 JF - The Journal of infectious diseases JO - J Infect Dis VL - 189 IS - 2 N2 - A prospective study of clinical and cytokine profiles of 107 infants with dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) was conducted. Fever, petechiae on the skin, and hepatomegaly were the most common clinical findings associated with DHF/DSS in infants. DSS occurred in 20.5% of the patients. Hemoconcentration and thrombocytopenia were observed in 91.5% and 92.5% of the patients, respectively. Serologic testing revealed that almost all of the patients (95.3%) had primary dengue virus infections. These data demonstrate that clinical and laboratory findings of DHF/DSS in infants are compatible with the World Health Organization's clinical diagnostic criteria for pediatric DHF. The present study is the first to report evidence of production of cytokines in infants with DHF/DSS and to describe the difference between the cytokine profile of infants with primary dengue virus infections and children with secondary infections. Overproduction of both proinflammatory cytokines (interferon-gamma and tumor necrosis factor-alpha) and anti-inflammatory cytokines (interleukin-10 and -6) may play a role in the pathogenesis of DHF/DSS in infants. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/14722886/Dengue_hemorrhagic_fever_in_infants:_a_study_of_clinical_and_cytokine_profiles_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/380762 DB - PRIME DP - Unbound Medicine ER -