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The co-expression of P2X3 receptor with VR1 and VRL-1 in the rat trigeminal ganglion.
Brain Res. 2004 Feb 13; 998(1):130-5.BR

Abstract

The co-expression of P2X3 receptor with the vanilloid receptor subtype I (VR1) and vanilloid receptor 1-like receptor (VRL-1) was examined in the rat trigeminal ganglion (TG) by a double immunofluorescence method. P2X3 receptor-immunoreactive (ir) neurons were predominantly small to medium-sized (range=93.8-1844.4 microm(2), mean+/-S.D.=503.8+/-286.5 microm(2)); 35% and 9% of P2X3 receptor-ir TG neurons were immunoreactive for VR1 and VRL-1, respectively. Small and medium-sized P2X3 receptor-ir neurons contained VR1-immunoreactivity (ir), whereas medium-sized and large P2X3 receptor-ir neurons showed VRL-1-ir. The retrograde tracing and immunohistochemical methods revealed that 30% of the TG neurons retrogradely labeled from the facial skin and tooth pulp exhibited P2X3 receptor-ir. The co-expression of P2X3 receptor and VR1 was detected in 16% of cutaneous TG neurons and 6% of tooth pulp neurons. On the other hand, the co-expression of P2X3 receptor and VRL-1 was common in tooth pulp neurons (23%) and rare in cutaneous TG neurons (8%). In the tooth pulp, 95% of P2X3 receptor-ir TG neurons contained VRL-1-ir. The present study indicates that P2X3 receptor-ir TG neurons, which co-express VR-ir, are abundant in the facial skin. The tooth pulp is probably innervated by TG neurons, which contain both P2X3-and VRL-1-ir.

Authors+Show Affiliations

Department of Oral Function and Anatomy, and Biodental Research Center, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8525, Japan. hiroichi@md.okayama-u.ac.jpNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14725976

Citation

Ichikawa, Hiroyuki, and Tomosada Sugimoto. "The Co-expression of P2X3 Receptor With VR1 and VRL-1 in the Rat Trigeminal Ganglion." Brain Research, vol. 998, no. 1, 2004, pp. 130-5.
Ichikawa H, Sugimoto T. The co-expression of P2X3 receptor with VR1 and VRL-1 in the rat trigeminal ganglion. Brain Res. 2004;998(1):130-5.
Ichikawa, H., & Sugimoto, T. (2004). The co-expression of P2X3 receptor with VR1 and VRL-1 in the rat trigeminal ganglion. Brain Research, 998(1), 130-5.
Ichikawa H, Sugimoto T. The Co-expression of P2X3 Receptor With VR1 and VRL-1 in the Rat Trigeminal Ganglion. Brain Res. 2004 Feb 13;998(1):130-5. PubMed PMID: 14725976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The co-expression of P2X3 receptor with VR1 and VRL-1 in the rat trigeminal ganglion. AU - Ichikawa,Hiroyuki, AU - Sugimoto,Tomosada, PY - 2004/1/17/pubmed PY - 2004/3/23/medline PY - 2004/1/17/entrez SP - 130 EP - 5 JF - Brain research JO - Brain Res. VL - 998 IS - 1 N2 - The co-expression of P2X3 receptor with the vanilloid receptor subtype I (VR1) and vanilloid receptor 1-like receptor (VRL-1) was examined in the rat trigeminal ganglion (TG) by a double immunofluorescence method. P2X3 receptor-immunoreactive (ir) neurons were predominantly small to medium-sized (range=93.8-1844.4 microm(2), mean+/-S.D.=503.8+/-286.5 microm(2)); 35% and 9% of P2X3 receptor-ir TG neurons were immunoreactive for VR1 and VRL-1, respectively. Small and medium-sized P2X3 receptor-ir neurons contained VR1-immunoreactivity (ir), whereas medium-sized and large P2X3 receptor-ir neurons showed VRL-1-ir. The retrograde tracing and immunohistochemical methods revealed that 30% of the TG neurons retrogradely labeled from the facial skin and tooth pulp exhibited P2X3 receptor-ir. The co-expression of P2X3 receptor and VR1 was detected in 16% of cutaneous TG neurons and 6% of tooth pulp neurons. On the other hand, the co-expression of P2X3 receptor and VRL-1 was common in tooth pulp neurons (23%) and rare in cutaneous TG neurons (8%). In the tooth pulp, 95% of P2X3 receptor-ir TG neurons contained VRL-1-ir. The present study indicates that P2X3 receptor-ir TG neurons, which co-express VR-ir, are abundant in the facial skin. The tooth pulp is probably innervated by TG neurons, which contain both P2X3-and VRL-1-ir. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/14725976/The_co_expression_of_P2X3_receptor_with_VR1_and_VRL_1_in_the_rat_trigeminal_ganglion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006899303040538 DB - PRIME DP - Unbound Medicine ER -