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Association between high serum ferritin levels and carotid atherosclerosis in the study of health in Pomerania (SHIP).
Stroke 2004; 35(2):453-7S

Abstract

BACKGROUND AND PURPOSE

Several studies have provided evidence for a relationship between body iron load and cardiovascular disease. We analyzed the association of serum ferritin levels with carotid atherosclerosis.

METHODS

We assessed intima-media thickness and plaque prevalence in the carotid arteries by high-resolution ultrasound among 2443 participants (1200 women; age, 45 to 79 years) in the Study of Health in Pomerania (SHIP), a population-based study in northeast Germany.

RESULTS

In multivariate analysis, serum ferritin levels were not independently associated with carotid intima-media thickness among women or men. In contrast, the relationship between serum ferritin levels and carotid plaque prevalence was significant among men (odds ratio per 1-SD increase of serum ferritin levels, 1.33; 95% confidence interval, 1.08 to 1.44) yet not among women (odds ratio, 1.29; 95% confidence interval, 0.98 to 1.75). However, both men and women showed a dose-response relation between serum ferritin levels and carotid atherosclerosis in which higher serum ferritin levels were associated with greater odds ratios for carotid plaque prevalence. Additionally, there was an interaction of serum ferritin levels with low-density lipoprotein (LDL) cholesterol (P=0.039) among men in which the association of serum ferritin levels with carotid plaque prevalence became stronger with increasing LDL cholesterol levels.

CONCLUSIONS

Our study identified a relationship between serum ferritin levels and carotid atherosclerosis that was potentiated by LDL cholesterol. This relationship adds support to the hypothesis of a link between iron and cardiovascular disease.

Authors+Show Affiliations

Klinik für Innere Medizin B, Universität Greifswald, Greifswald, Germany. birger.wolff@uni-greifswald.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14726541

Citation

Wolff, Birger, et al. "Association Between High Serum Ferritin Levels and Carotid Atherosclerosis in the Study of Health in Pomerania (SHIP)." Stroke, vol. 35, no. 2, 2004, pp. 453-7.
Wolff B, Völzke H, Lüdemann J, et al. Association between high serum ferritin levels and carotid atherosclerosis in the study of health in Pomerania (SHIP). Stroke. 2004;35(2):453-7.
Wolff, B., Völzke, H., Lüdemann, J., Robinson, D., Vogelgesang, D., Staudt, A., ... Felix, S. B. (2004). Association between high serum ferritin levels and carotid atherosclerosis in the study of health in Pomerania (SHIP). Stroke, 35(2), pp. 453-7.
Wolff B, et al. Association Between High Serum Ferritin Levels and Carotid Atherosclerosis in the Study of Health in Pomerania (SHIP). Stroke. 2004;35(2):453-7. PubMed PMID: 14726541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between high serum ferritin levels and carotid atherosclerosis in the study of health in Pomerania (SHIP). AU - Wolff,Birger, AU - Völzke,Henry, AU - Lüdemann,Jan, AU - Robinson,Daniel, AU - Vogelgesang,Dirk, AU - Staudt,Alexander, AU - Kessler,Christof, AU - Dahm,Johannes B, AU - John,Ulrich, AU - Felix,Stephan B, Y1 - 2004/01/15/ PY - 2004/1/17/pubmed PY - 2004/4/7/medline PY - 2004/1/17/entrez SP - 453 EP - 7 JF - Stroke JO - Stroke VL - 35 IS - 2 N2 - BACKGROUND AND PURPOSE: Several studies have provided evidence for a relationship between body iron load and cardiovascular disease. We analyzed the association of serum ferritin levels with carotid atherosclerosis. METHODS: We assessed intima-media thickness and plaque prevalence in the carotid arteries by high-resolution ultrasound among 2443 participants (1200 women; age, 45 to 79 years) in the Study of Health in Pomerania (SHIP), a population-based study in northeast Germany. RESULTS: In multivariate analysis, serum ferritin levels were not independently associated with carotid intima-media thickness among women or men. In contrast, the relationship between serum ferritin levels and carotid plaque prevalence was significant among men (odds ratio per 1-SD increase of serum ferritin levels, 1.33; 95% confidence interval, 1.08 to 1.44) yet not among women (odds ratio, 1.29; 95% confidence interval, 0.98 to 1.75). However, both men and women showed a dose-response relation between serum ferritin levels and carotid atherosclerosis in which higher serum ferritin levels were associated with greater odds ratios for carotid plaque prevalence. Additionally, there was an interaction of serum ferritin levels with low-density lipoprotein (LDL) cholesterol (P=0.039) among men in which the association of serum ferritin levels with carotid plaque prevalence became stronger with increasing LDL cholesterol levels. CONCLUSIONS: Our study identified a relationship between serum ferritin levels and carotid atherosclerosis that was potentiated by LDL cholesterol. This relationship adds support to the hypothesis of a link between iron and cardiovascular disease. SN - 1524-4628 UR - https://www.unboundmedicine.com/medline/citation/14726541/Association_between_high_serum_ferritin_levels_and_carotid_atherosclerosis_in_the_study_of_health_in_Pomerania__SHIP__ L2 - http://www.ahajournals.org/doi/full/10.1161/01.STR.0000114875.31599.1C?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -