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The effect of oral mucositis on morbidity and mortality in bone marrow transplant.
Semin Oncol 2003; 30(6 Suppl 18):76-83SO

Abstract

Oral mucosal ulceration is a frequent complication in bone marrow transplantation, resulting from epithelial injury caused by cytotoxic chemotherapy and radiation conditioning, as well as from pre-existing infection. Oral mucositis causes pain, interferes with patient nutrition, and can lead to systemic infection and other complications that increase patient morbidity and mortality; this complication also markedly increases the expense of bone marrow transplantation. A variety of interventions have been assessed for preventing oral mucositis or reducing the severity of mucositis and its sequelae. These include meticulous pretransplantation and ongoing mouth care, calcium phosphate solution, near-infrared light and lower-energy laser treatment, interleukin-11, sucralfate, oral glutamine, granulocyte-macrophage colony-stimulating factor rinse, tretinoin, and keratinocyte growth factor; particularly promising results have been observed with use of the cytoprotectant/radioprotectant agent amifostine. Reduction in the severity and duration of oral mucositis and its sequelae in patients undergoing bone marrow transplantation can have a substantial impact on morbidity and mortality and cost of care. Further systematic evaluation of approaches to prevention and management of oral mucositis is necessary to define optimal strategies in the transplantation setting.

Authors+Show Affiliations

Department of Medicine, University of North Carolina School of Medicine, Chapel Hill 27599, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

14727245

Citation

Gabriel, Don A., et al. "The Effect of Oral Mucositis On Morbidity and Mortality in Bone Marrow Transplant." Seminars in Oncology, vol. 30, no. 6 Suppl 18, 2003, pp. 76-83.
Gabriel DA, Shea T, Olajida O, et al. The effect of oral mucositis on morbidity and mortality in bone marrow transplant. Semin Oncol. 2003;30(6 Suppl 18):76-83.
Gabriel, D. A., Shea, T., Olajida, O., Serody, J. S., & Comeau, T. (2003). The effect of oral mucositis on morbidity and mortality in bone marrow transplant. Seminars in Oncology, 30(6 Suppl 18), pp. 76-83.
Gabriel DA, et al. The Effect of Oral Mucositis On Morbidity and Mortality in Bone Marrow Transplant. Semin Oncol. 2003;30(6 Suppl 18):76-83. PubMed PMID: 14727245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of oral mucositis on morbidity and mortality in bone marrow transplant. AU - Gabriel,Don A, AU - Shea,Thomas, AU - Olajida,Oludamilola, AU - Serody,Jonathan S, AU - Comeau,Terrance, PY - 2004/1/17/pubmed PY - 2004/2/18/medline PY - 2004/1/17/entrez SP - 76 EP - 83 JF - Seminars in oncology JO - Semin. Oncol. VL - 30 IS - 6 Suppl 18 N2 - Oral mucosal ulceration is a frequent complication in bone marrow transplantation, resulting from epithelial injury caused by cytotoxic chemotherapy and radiation conditioning, as well as from pre-existing infection. Oral mucositis causes pain, interferes with patient nutrition, and can lead to systemic infection and other complications that increase patient morbidity and mortality; this complication also markedly increases the expense of bone marrow transplantation. A variety of interventions have been assessed for preventing oral mucositis or reducing the severity of mucositis and its sequelae. These include meticulous pretransplantation and ongoing mouth care, calcium phosphate solution, near-infrared light and lower-energy laser treatment, interleukin-11, sucralfate, oral glutamine, granulocyte-macrophage colony-stimulating factor rinse, tretinoin, and keratinocyte growth factor; particularly promising results have been observed with use of the cytoprotectant/radioprotectant agent amifostine. Reduction in the severity and duration of oral mucositis and its sequelae in patients undergoing bone marrow transplantation can have a substantial impact on morbidity and mortality and cost of care. Further systematic evaluation of approaches to prevention and management of oral mucositis is necessary to define optimal strategies in the transplantation setting. SN - 0093-7754 UR - https://www.unboundmedicine.com/medline/citation/14727245/The_effect_of_oral_mucositis_on_morbidity_and_mortality_in_bone_marrow_transplant_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0093775403006080 DB - PRIME DP - Unbound Medicine ER -