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Method to recover a lipophilic drug from hydroxypropyl methylcellulose matrix tablets.
AAPS PharmSciTech. 2001 Jun 09; 2(2):E8.AP

Abstract

A reverse-phase high-performance liquid chromatographic (HPLC) method for recovery of the lipophilic drug, alprazolam, from matrix tablets containing the hydrophilic polymer hydroxypropyl methylcellulose (HPMC) was developed. Lipophilic drugs, such as alprazolam, are difficult to completely extract and quantitate from tablets containing HPMC polymer. The percentage of recoveries of alprazolam from placebo powder spiked with alprazolam stock solution and from placebo powder mixed with alprazolam powder were about 100% and 85% to 95%, respectively. The validated method using water to completely dissolve HPMC before the addition of a strong solvent to dissolve and extract the drug from the HPMC solution was shown to be the most reproducible method. Different molecular weight distributions of the HPMC polymer, such as HPMC-K4M and HPMC-K100LV, did not influence the dissolution results of alprazolam using this validated method. Similarly, the excipients composing the matrix tablet formulations, such as dicalcium phosphate dihydrate, dicalcium phosphate anhydrous, calcium sulfate dihydrate, sucrose, dextrose, and lactose monohydrate, did not influence the percent recovery of alprazolam. The recovery method reported herein was shown to be the most efficient to achieve complete recovery of alprazolam from powder blends and tablets containing a variety of excipients and different grades of HPMC.

Links

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Authors+Show Affiliations

Williams RO
Division of Pharmaceutics, College of Pharmacy, The University of Texas, Austin 78712-1074, USA. WILLIRO@mail.utexas.edu
Sykora MA
No affiliation info available
Mahaguna V
No affiliation info available

MeSH

AlprazolamCalorimetry, Differential ScanningChemistry, PharmaceuticalChromatography, High Pressure LiquidDelayed-Action PreparationsDrug CarriersDrug CompoundingExcipientsLactoseMethylcelluloseMolecular WeightOxazinesPolymersSolubilityTabletsViscosity

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14727883

Citation

Williams, R O., et al. "Method to Recover a Lipophilic Drug From Hydroxypropyl Methylcellulose Matrix Tablets." AAPS PharmSciTech, vol. 2, no. 2, 2001, pp. E8.
Williams RO, Sykora MA, Mahaguna V. Method to recover a lipophilic drug from hydroxypropyl methylcellulose matrix tablets. AAPS PharmSciTech. 2001;2(2):E8.
Williams, R. O., Sykora, M. A., & Mahaguna, V. (2001). Method to recover a lipophilic drug from hydroxypropyl methylcellulose matrix tablets. AAPS PharmSciTech, 2(2), E8.
Williams RO, Sykora MA, Mahaguna V. Method to Recover a Lipophilic Drug From Hydroxypropyl Methylcellulose Matrix Tablets. AAPS PharmSciTech. 2001 Jun 9;2(2):E8. PubMed PMID: 14727883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Method to recover a lipophilic drug from hydroxypropyl methylcellulose matrix tablets. AU - Williams,R O,3rd AU - Sykora,M A, AU - Mahaguna,V, Y1 - 2001/06/09/ PY - 2004/1/20/pubmed PY - 2004/2/24/medline PY - 2004/1/20/entrez SP - E8 EP - E8 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 2 IS - 2 N2 - A reverse-phase high-performance liquid chromatographic (HPLC) method for recovery of the lipophilic drug, alprazolam, from matrix tablets containing the hydrophilic polymer hydroxypropyl methylcellulose (HPMC) was developed. Lipophilic drugs, such as alprazolam, are difficult to completely extract and quantitate from tablets containing HPMC polymer. The percentage of recoveries of alprazolam from placebo powder spiked with alprazolam stock solution and from placebo powder mixed with alprazolam powder were about 100% and 85% to 95%, respectively. The validated method using water to completely dissolve HPMC before the addition of a strong solvent to dissolve and extract the drug from the HPMC solution was shown to be the most reproducible method. Different molecular weight distributions of the HPMC polymer, such as HPMC-K4M and HPMC-K100LV, did not influence the dissolution results of alprazolam using this validated method. Similarly, the excipients composing the matrix tablet formulations, such as dicalcium phosphate dihydrate, dicalcium phosphate anhydrous, calcium sulfate dihydrate, sucrose, dextrose, and lactose monohydrate, did not influence the percent recovery of alprazolam. The recovery method reported herein was shown to be the most efficient to achieve complete recovery of alprazolam from powder blends and tablets containing a variety of excipients and different grades of HPMC. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/14727883/Method_to_recover_a_lipophilic_drug_from_hydroxypropyl_methylcellulose_matrix_tablets_ DB - PRIME DP - Unbound Medicine ER -