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[Study on the relationship between activin A, follistatin and preeclampsia].
Zhonghua Fu Chan Ke Za Zhi. 2003 Nov; 38(11):676-9.ZF

Abstract

OBJECTIVE

The purpose of this study was to determine the relationship of maternal serum activin A, follistatin and their mRNA expression in placenta with preeclampsia at term.

METHODS

Twenty women with preeclampsia were enrolled in this study. Twenty healthy pregnancies matched for gestational ages were recruited as control group. Maternal serum activin A and follistatin in two groups were compared by using enzyme linked immunosorbent assay (ELISA). Placental tissues were obtained from preeclampsia and healthy control groups for analysis of activin A mRNA and follistatin mRNA expression by using quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Linear correlation analysis was used to explore the relationship between placental avtivin A mRNA and maternal serum activin A concentrations.

RESULTS

(1) Maternal serum concentrations of activin A are significantly increased in preeclampsia group (33.7 +/- 6.6) micro g/L compared with control group (9.9 +/- 2.1) micro g/L (P < 0.01). Maternal serum follistatin levels were not different between preeclampsia group (5.1 +/- 0.6) micro g/L and control group (4.7 +/- 0.3) micro g/L (P > 0.05). (2) The placentas of preeclampsia group expressed activin A mRNA levels at significantly higher levels 1.11 +/- 0.21 than that of control group 0.61 +/- 0.17 (P < 0.01). The expression of follistatin mRNA were not different between preeclampsia group 0.57 +/- 0.31 and control group 0.54 +/- 0.27 (P > 0.05). (3) In preeclampsia and control groups, maternal serum activin A concentrations had a significant positive correlation with activin A mRNA expression in placentas (r = 0.89, P < 0.01).

CONCLUSION

These results suggest that activin A is increased in women with preeclampsia, the elevated levels of activin A due to increased placental production.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Second College of China Medical University, Shenyang 110004, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

14728855

Citation

Zhao, Liang, et al. "[Study On the Relationship Between Activin A, Follistatin and Preeclampsia]." Zhonghua Fu Chan Ke Za Zhi, vol. 38, no. 11, 2003, pp. 676-9.
Zhao L, Shang T, Wang YL, et al. [Study on the relationship between activin A, follistatin and preeclampsia]. Zhonghua Fu Chan Ke Za Zhi. 2003;38(11):676-9.
Zhao, L., Shang, T., Wang, Y. L., Tang, S., Li, H., & Liu, Z. H. (2003). [Study on the relationship between activin A, follistatin and preeclampsia]. Zhonghua Fu Chan Ke Za Zhi, 38(11), 676-9.
Zhao L, et al. [Study On the Relationship Between Activin A, Follistatin and Preeclampsia]. Zhonghua Fu Chan Ke Za Zhi. 2003;38(11):676-9. PubMed PMID: 14728855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on the relationship between activin A, follistatin and preeclampsia]. AU - Zhao,Liang, AU - Shang,Tao, AU - Wang,Yan-ling, AU - Tang,Shuang, AU - Li,Hui, AU - Liu,Zhong-hui, PY - 2004/1/20/pubmed PY - 2004/4/1/medline PY - 2004/1/20/entrez SP - 676 EP - 9 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 38 IS - 11 N2 - OBJECTIVE: The purpose of this study was to determine the relationship of maternal serum activin A, follistatin and their mRNA expression in placenta with preeclampsia at term. METHODS: Twenty women with preeclampsia were enrolled in this study. Twenty healthy pregnancies matched for gestational ages were recruited as control group. Maternal serum activin A and follistatin in two groups were compared by using enzyme linked immunosorbent assay (ELISA). Placental tissues were obtained from preeclampsia and healthy control groups for analysis of activin A mRNA and follistatin mRNA expression by using quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Linear correlation analysis was used to explore the relationship between placental avtivin A mRNA and maternal serum activin A concentrations. RESULTS: (1) Maternal serum concentrations of activin A are significantly increased in preeclampsia group (33.7 +/- 6.6) micro g/L compared with control group (9.9 +/- 2.1) micro g/L (P < 0.01). Maternal serum follistatin levels were not different between preeclampsia group (5.1 +/- 0.6) micro g/L and control group (4.7 +/- 0.3) micro g/L (P > 0.05). (2) The placentas of preeclampsia group expressed activin A mRNA levels at significantly higher levels 1.11 +/- 0.21 than that of control group 0.61 +/- 0.17 (P < 0.01). The expression of follistatin mRNA were not different between preeclampsia group 0.57 +/- 0.31 and control group 0.54 +/- 0.27 (P > 0.05). (3) In preeclampsia and control groups, maternal serum activin A concentrations had a significant positive correlation with activin A mRNA expression in placentas (r = 0.89, P < 0.01). CONCLUSION: These results suggest that activin A is increased in women with preeclampsia, the elevated levels of activin A due to increased placental production. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/14728855/[Study_on_the_relationship_between_activin_A_follistatin_and_preeclampsia]_ L2 - http://www.diseaseinfosearch.org/result/5920 DB - PRIME DP - Unbound Medicine ER -