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Effect of ethanol on the electrophysiological characteristics of pulmonary vein cardiomyocytes.
Eur J Pharmacol. 2004 Jan 12; 483(2-3):215-22.EJ

Abstract

Ethanol consumption has been considered to contribute to the occurrences of paroxysmal atrial fibrillation. Pulmonary veins are known to initiate atrial fibrillation. This study investigated whether ethanol may induce atrial fibrillation through increasing arrhythmogenic activity of pulmonary vein cardiomyocytes. Using the whole-cell clamp technique, the action potential and ionic currents were investigated in rabbit single pulmonary vein beating cardiomyocytes with and without (control) incubation of ethanol. Compared with control cardiomyocytes, pulmonary vein cardiomyocytes receiving 0.3 mg/ml or 1 mg/ml ethanol had shorter action potential duration, but had similar beating rates (2.6+/-1.3, 2.7+/-1.2, 2.7+/-1.2 Hz) and incidences (45%, 41%, 32%) of delayed after depolarization. Pulmonary vein cardiomyocytes receiving ethanol had smaller L-type Ca(2+) currents and larger transient outward currents, but had similar transient inward, delayed rectified outward, inward rectified and pacemaker currents. These results suggest that ethanol has no direct effect on the arrhythmogenic potential of pulmonary vein cardiomyocytes.

Authors+Show Affiliations

Chen YC
Department of Biomedical Engineering, National Defense Medical Center, Taipei, Taiwan
Chen SA
No affiliation info available
Chen YJ
No affiliation info available
Tai CT
No affiliation info available
Chan P
No affiliation info available
Lin CI
No affiliation info available

MeSH

Action PotentialsAnimalsElectrophysiologyEthanolMyocytes, CardiacPulmonary VeinsRabbits

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14729109

Citation

Chen, Yao-Chang, et al. "Effect of Ethanol On the Electrophysiological Characteristics of Pulmonary Vein Cardiomyocytes." European Journal of Pharmacology, vol. 483, no. 2-3, 2004, pp. 215-22.
Chen YC, Chen SA, Chen YJ, et al. Effect of ethanol on the electrophysiological characteristics of pulmonary vein cardiomyocytes. Eur J Pharmacol. 2004;483(2-3):215-22.
Chen, Y. C., Chen, S. A., Chen, Y. J., Tai, C. T., Chan, P., & Lin, C. I. (2004). Effect of ethanol on the electrophysiological characteristics of pulmonary vein cardiomyocytes. European Journal of Pharmacology, 483(2-3), 215-22.
Chen YC, et al. Effect of Ethanol On the Electrophysiological Characteristics of Pulmonary Vein Cardiomyocytes. Eur J Pharmacol. 2004 Jan 12;483(2-3):215-22. PubMed PMID: 14729109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of ethanol on the electrophysiological characteristics of pulmonary vein cardiomyocytes. AU - Chen,Yao-Chang, AU - Chen,Shih-Ann, AU - Chen,Yi-Jen, AU - Tai,Ching-Tai, AU - Chan,Paul, AU - Lin,Cheng-I, PY - 2004/1/20/pubmed PY - 2004/9/24/medline PY - 2004/1/20/entrez SP - 215 EP - 22 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 483 IS - 2-3 N2 - Ethanol consumption has been considered to contribute to the occurrences of paroxysmal atrial fibrillation. Pulmonary veins are known to initiate atrial fibrillation. This study investigated whether ethanol may induce atrial fibrillation through increasing arrhythmogenic activity of pulmonary vein cardiomyocytes. Using the whole-cell clamp technique, the action potential and ionic currents were investigated in rabbit single pulmonary vein beating cardiomyocytes with and without (control) incubation of ethanol. Compared with control cardiomyocytes, pulmonary vein cardiomyocytes receiving 0.3 mg/ml or 1 mg/ml ethanol had shorter action potential duration, but had similar beating rates (2.6+/-1.3, 2.7+/-1.2, 2.7+/-1.2 Hz) and incidences (45%, 41%, 32%) of delayed after depolarization. Pulmonary vein cardiomyocytes receiving ethanol had smaller L-type Ca(2+) currents and larger transient outward currents, but had similar transient inward, delayed rectified outward, inward rectified and pacemaker currents. These results suggest that ethanol has no direct effect on the arrhythmogenic potential of pulmonary vein cardiomyocytes. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/14729109/Effect_of_ethanol_on_the_electrophysiological_characteristics_of_pulmonary_vein_cardiomyocytes_ DB - PRIME DP - Unbound Medicine ER -