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Antimicrobial resistance in the nasopharyngeal flora of children with acute maxillary sinusitis and maxillary sinusitis recurring after amoxicillin therapy.
J Antimicrob Chemother. 2004 Feb; 53(2):399-402.JA

Abstract

OBJECTIVE

To investigate the antimicrobial susceptibility of the organisms isolated from the nasopharynx of children who present with acute maxillary sinusitis (AMS) or maxillary sinusitis that recurred (RMS) after amoxicillin therapy.

METHODS

Analysis of nasopharyngeal cultures obtained from 70 patients, 42 with AMS and 28 with RMS.

RESULTS

Thirty-eight potentially pathogenic organisms were recovered in 36 (86%) of the children from the AMS group, and 40 were isolated from 26 (93%) of the children from the RMS group. The organisms isolated were Streptococcus pneumoniae (21 isolates), Haemophilus influenzae non-type b (17), Moraxella catarrhalis (15), Streptococcus pyogenes (13) and Staphylococcus aureus (12). Resistance to the eight antimicrobial agents used was found in 34 instances in the AMS group compared to 93 instances in the RMS group (P < 0.005). The difference between AMS and RMS was significant with S. pneumoniae resistance to amoxicillin (P < 0.0025), to co-amoxiclav (P < 0.0025), to trimethoprim-sulfamethoxazole (P < 0.05), to cefixime (P < 0.05), and to azithromycin (P < 0.05), and for H. influenzae to amoxicillin (P < 0.025).

CONCLUSIONS

These data illustrate the higher recovery rate of antimicrobial-resistant S. pneumoniae and H. influenzae from the nasopharynx of children who had maxillary sinusitis that recurred after amoxicillin therapy than those with AMS.

Authors+Show Affiliations

Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St. NW, Washington, DC 20016, USA. ib6@georgetown.eduNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14729759

Citation

Brook, Itzhak, and Alan E. Gober. "Antimicrobial Resistance in the Nasopharyngeal Flora of Children With Acute Maxillary Sinusitis and Maxillary Sinusitis Recurring After Amoxicillin Therapy." The Journal of Antimicrobial Chemotherapy, vol. 53, no. 2, 2004, pp. 399-402.
Brook I, Gober AE. Antimicrobial resistance in the nasopharyngeal flora of children with acute maxillary sinusitis and maxillary sinusitis recurring after amoxicillin therapy. J Antimicrob Chemother. 2004;53(2):399-402.
Brook, I., & Gober, A. E. (2004). Antimicrobial resistance in the nasopharyngeal flora of children with acute maxillary sinusitis and maxillary sinusitis recurring after amoxicillin therapy. The Journal of Antimicrobial Chemotherapy, 53(2), 399-402.
Brook I, Gober AE. Antimicrobial Resistance in the Nasopharyngeal Flora of Children With Acute Maxillary Sinusitis and Maxillary Sinusitis Recurring After Amoxicillin Therapy. J Antimicrob Chemother. 2004;53(2):399-402. PubMed PMID: 14729759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial resistance in the nasopharyngeal flora of children with acute maxillary sinusitis and maxillary sinusitis recurring after amoxicillin therapy. AU - Brook,Itzhak, AU - Gober,Alan E, Y1 - 2004/01/16/ PY - 2004/1/20/pubmed PY - 2004/4/21/medline PY - 2004/1/20/entrez SP - 399 EP - 402 JF - The Journal of antimicrobial chemotherapy JO - J Antimicrob Chemother VL - 53 IS - 2 N2 - OBJECTIVE: To investigate the antimicrobial susceptibility of the organisms isolated from the nasopharynx of children who present with acute maxillary sinusitis (AMS) or maxillary sinusitis that recurred (RMS) after amoxicillin therapy. METHODS: Analysis of nasopharyngeal cultures obtained from 70 patients, 42 with AMS and 28 with RMS. RESULTS: Thirty-eight potentially pathogenic organisms were recovered in 36 (86%) of the children from the AMS group, and 40 were isolated from 26 (93%) of the children from the RMS group. The organisms isolated were Streptococcus pneumoniae (21 isolates), Haemophilus influenzae non-type b (17), Moraxella catarrhalis (15), Streptococcus pyogenes (13) and Staphylococcus aureus (12). Resistance to the eight antimicrobial agents used was found in 34 instances in the AMS group compared to 93 instances in the RMS group (P < 0.005). The difference between AMS and RMS was significant with S. pneumoniae resistance to amoxicillin (P < 0.0025), to co-amoxiclav (P < 0.0025), to trimethoprim-sulfamethoxazole (P < 0.05), to cefixime (P < 0.05), and to azithromycin (P < 0.05), and for H. influenzae to amoxicillin (P < 0.025). CONCLUSIONS: These data illustrate the higher recovery rate of antimicrobial-resistant S. pneumoniae and H. influenzae from the nasopharynx of children who had maxillary sinusitis that recurred after amoxicillin therapy than those with AMS. SN - 0305-7453 UR - https://www.unboundmedicine.com/medline/citation/14729759/Antimicrobial_resistance_in_the_nasopharyngeal_flora_of_children_with_acute_maxillary_sinusitis_and_maxillary_sinusitis_recurring_after_amoxicillin_therapy_ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dkh061 DB - PRIME DP - Unbound Medicine ER -