Tags

Type your tag names separated by a space and hit enter

Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study.
Arthritis Rheum 2004; 50(1):72-7AR

Abstract

OBJECTIVE

Vitamin D is a potent regulator of calcium homeostasis and may have immunomodulatory effects. The influence of vitamin D on human autoimmune disease has not been well defined. The purpose of this study was to evaluate the association of dietary and supplemental vitamin D intake with rheumatoid arthritis (RA) incidence.

METHODS

We analyzed data from a prospective cohort study of 29,368 women of ages 55-69 years without a history of RA at study baseline in 1986. Diet was ascertained using a self-administered, 127-item validated food frequency questionnaire that included supplemental vitamin D use. Risk ratios (RRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards regression, adjusting for potential confounders.

RESULTS

Through 11 years of followup, 152 cases of RA were validated against medical records. Greater intake (highest versus lowest tertile) of vitamin D was inversely associated with risk of RA (RR 0.67, 95% CI 0.44-1.00, P for trend = 0.05). Inverse associations were apparent for both dietary (RR 0.72, 95% CI 0.46-1.14, P for trend = 0.16) and supplemental (RR 0.66, 95% CI 0.43-1.00, P for trend = 0.03) vitamin D. No individual food item high in vitamin D content and/or calcium was strongly associated with RA risk, but a composite measure of milk products was suggestive of an inverse association with risk of RA (RR 0.66, 95% CI 0.42-1.01, P for trend = 0.06).

CONCLUSION

Greater intake of vitamin D may be associated with a lower risk of RA in older women, although this finding is hypothesis generating.

Authors+Show Affiliations

College of Public Health, University of Iowa, Iowa City.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14730601

Citation

Merlino, Linda A., et al. "Vitamin D Intake Is Inversely Associated With Rheumatoid Arthritis: Results From the Iowa Women's Health Study." Arthritis and Rheumatism, vol. 50, no. 1, 2004, pp. 72-7.
Merlino LA, Curtis J, Mikuls TR, et al. Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study. Arthritis Rheum. 2004;50(1):72-7.
Merlino, L. A., Curtis, J., Mikuls, T. R., Cerhan, J. R., Criswell, L. A., & Saag, K. G. (2004). Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study. Arthritis and Rheumatism, 50(1), pp. 72-7.
Merlino LA, et al. Vitamin D Intake Is Inversely Associated With Rheumatoid Arthritis: Results From the Iowa Women's Health Study. Arthritis Rheum. 2004;50(1):72-7. PubMed PMID: 14730601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study. AU - Merlino,Linda A, AU - Curtis,Jeffrey, AU - Mikuls,Ted R, AU - Cerhan,James R, AU - Criswell,Lindsey A, AU - Saag,Kenneth G, AU - ,, PY - 2004/1/20/pubmed PY - 2004/2/18/medline PY - 2004/1/20/entrez SP - 72 EP - 7 JF - Arthritis and rheumatism JO - Arthritis Rheum. VL - 50 IS - 1 N2 - OBJECTIVE: Vitamin D is a potent regulator of calcium homeostasis and may have immunomodulatory effects. The influence of vitamin D on human autoimmune disease has not been well defined. The purpose of this study was to evaluate the association of dietary and supplemental vitamin D intake with rheumatoid arthritis (RA) incidence. METHODS: We analyzed data from a prospective cohort study of 29,368 women of ages 55-69 years without a history of RA at study baseline in 1986. Diet was ascertained using a self-administered, 127-item validated food frequency questionnaire that included supplemental vitamin D use. Risk ratios (RRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards regression, adjusting for potential confounders. RESULTS: Through 11 years of followup, 152 cases of RA were validated against medical records. Greater intake (highest versus lowest tertile) of vitamin D was inversely associated with risk of RA (RR 0.67, 95% CI 0.44-1.00, P for trend = 0.05). Inverse associations were apparent for both dietary (RR 0.72, 95% CI 0.46-1.14, P for trend = 0.16) and supplemental (RR 0.66, 95% CI 0.43-1.00, P for trend = 0.03) vitamin D. No individual food item high in vitamin D content and/or calcium was strongly associated with RA risk, but a composite measure of milk products was suggestive of an inverse association with risk of RA (RR 0.66, 95% CI 0.42-1.01, P for trend = 0.06). CONCLUSION: Greater intake of vitamin D may be associated with a lower risk of RA in older women, although this finding is hypothesis generating. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/14730601/Vitamin_D_intake_is_inversely_associated_with_rheumatoid_arthritis:_results_from_the_Iowa_Women's_Health_Study_ L2 - https://doi.org/10.1002/art.11434 DB - PRIME DP - Unbound Medicine ER -