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[Effects of interleukin-1 receptor antagonist on the apoptosis of eosinophil in guinea pig with asthma].
Yao Xue Xue Bao. 2003 Sep; 38(9):661-4.YX

Abstract

AIM

To evaluate the effect of interleukin-1 receptor antagonist(IL-1ra) on apoptosis and associated mechanism of eosinophil in guinea pig with asthma.

METHODS

A model of guinea pig with asthma was established. After inhalation of different concentrations of IL-1ra, asthma was induced in the guinea pig for 8 days, the concentration of eosinophil cationic protein (ECP) in serum and bronchoalveolar lavage fluid (BALF), IL-5 in serum, the eosinophil counts and apoptosis were assayed by radioimmunology, enzyme-linked immunosorbent assay(ELISA), fluoromicroscope and light microscope.

RESULTS

IL-1ra indirectly decreased the level of IL-5 in serum, improved the apoptosis of eosinophil(EOS) in lung, then decreased the level of ECP in serum and BALF.

CONCLUSION

Inhalation of nebulized IL-1ra showed protective effect against asthma through change of the activity and infiltration of EOS in lung.

Authors+Show Affiliations

Xu F
Medical and Pharmacological, Institute of Yangzhou University, Yangzhou 225001, China.
Zhang HQ
No affiliation info available

MeSH

AnimalsApoptosisAsthmaBlood ProteinsBronchoalveolar Lavage FluidEosinophil Granule ProteinsEosinophilsFemaleGuinea PigsInterleukin 1 Receptor Antagonist ProteinInterleukin-5Leukocyte CountMaleOvalbuminRandom AllocationReceptors, Interleukin-1RibonucleasesSialoglycoproteins

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

14730914

Citation

Xu, Feng, and Hong-quan Zhang. "[Effects of Interleukin-1 Receptor Antagonist On the Apoptosis of Eosinophil in Guinea Pig With Asthma]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 38, no. 9, 2003, pp. 661-4.
Xu F, Zhang HQ. [Effects of interleukin-1 receptor antagonist on the apoptosis of eosinophil in guinea pig with asthma]. Yao Xue Xue Bao. 2003;38(9):661-4.
Xu, F., & Zhang, H. Q. (2003). [Effects of interleukin-1 receptor antagonist on the apoptosis of eosinophil in guinea pig with asthma]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 38(9), 661-4.
Xu F, Zhang HQ. [Effects of Interleukin-1 Receptor Antagonist On the Apoptosis of Eosinophil in Guinea Pig With Asthma]. Yao Xue Xue Bao. 2003;38(9):661-4. PubMed PMID: 14730914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of interleukin-1 receptor antagonist on the apoptosis of eosinophil in guinea pig with asthma]. AU - Xu,Feng, AU - Zhang,Hong-quan, PY - 2004/1/21/pubmed PY - 2004/5/7/medline PY - 2004/1/21/entrez SP - 661 EP - 4 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 38 IS - 9 N2 - AIM: To evaluate the effect of interleukin-1 receptor antagonist(IL-1ra) on apoptosis and associated mechanism of eosinophil in guinea pig with asthma. METHODS: A model of guinea pig with asthma was established. After inhalation of different concentrations of IL-1ra, asthma was induced in the guinea pig for 8 days, the concentration of eosinophil cationic protein (ECP) in serum and bronchoalveolar lavage fluid (BALF), IL-5 in serum, the eosinophil counts and apoptosis were assayed by radioimmunology, enzyme-linked immunosorbent assay(ELISA), fluoromicroscope and light microscope. RESULTS: IL-1ra indirectly decreased the level of IL-5 in serum, improved the apoptosis of eosinophil(EOS) in lung, then decreased the level of ECP in serum and BALF. CONCLUSION: Inhalation of nebulized IL-1ra showed protective effect against asthma through change of the activity and infiltration of EOS in lung. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/14730914/[Effects_of_interleukin_1_receptor_antagonist_on_the_apoptosis_of_eosinophil_in_guinea_pig_with_asthma]_ DB - PRIME DP - Unbound Medicine ER -