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Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study.

Abstract

BACKGROUND

Antioxidants may protect the aging brain against oxidative damage associated with pathological changes of Alzheimer disease (AD).

OBJECTIVE

To examine the relationship between antioxidant supplement use and risk of AD.

DESIGN

Cross-sectional and prospective study of dementia. Elderly (65 years or older) county residents were assessed in 1995 to 1997 for prevalent dementia and AD, and again in 1998 to 2000 for incident illness. Supplement use was ascertained at the first contact.

SETTING

Cache County, Utah.

PARTICIPANTS

Among 4740 respondents (93%) with data sufficient to determine cognitive status at the initial assessment, we identified 200 prevalent cases of AD. Among 3227 survivors at risk, we identified 104 incident AD cases at follow-up.

MAIN OUTCOME MEASURE

Diagnosis of AD by means of multistage assessment procedures.

RESULTS

Analyses of prevalent and incident AD yielded similar results. Use of vitamin E and C (ascorbic acid) supplements in combination was associated with reduced AD prevalence (adjusted odds ratio, 0.22; 95% confidence interval, 0.05-0.60) and incidence (adjusted hazard ratio, 0.36; 95% confidence interval, 0.09-0.99). A trend toward lower AD risk was also evident in users of vitamin E and multivitamins containing vitamin C, but we saw no evidence of a protective effect with use of vitamin E or vitamin C supplements alone, with multivitamins alone, or with vitamin B-complex supplements.

CONCLUSIONS

Use of vitamin E and vitamin C supplements in combination is associated with reduced prevalence and incidence of AD. Antioxidant supplements merit further study as agents for the primary prevention of AD.

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  • Authors+Show Affiliations

    ,

    Department of Mental Health, Bloomberg School of Public Health, The Johns Hopkins University, Hampton House Room 857, 624 N Broadway, Baltimore, MD 21205, USA. pzandi@jhsph.edu

    , , , , , , , ,

    Source

    Archives of neurology 61:1 2004 Jan pg 82-8

    MeSH

    Aged
    Alzheimer Disease
    Antioxidants
    Ascorbic Acid
    Cross-Sectional Studies
    Dietary Supplements
    Female
    Humans
    Incidence
    Male
    Middle Aged
    Prevalence
    Prospective Studies
    Risk Factors
    Vitamin E

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    14732624

    Citation

    Zandi, Peter P., et al. "Reduced Risk of Alzheimer Disease in Users of Antioxidant Vitamin Supplements: the Cache County Study." Archives of Neurology, vol. 61, no. 1, 2004, pp. 82-8.
    Zandi PP, Anthony JC, Khachaturian AS, et al. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch Neurol. 2004;61(1):82-8.
    Zandi, P. P., Anthony, J. C., Khachaturian, A. S., Stone, S. V., Gustafson, D., Tschanz, J. T., ... Breitner, J. C. (2004). Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Archives of Neurology, 61(1), pp. 82-8.
    Zandi PP, et al. Reduced Risk of Alzheimer Disease in Users of Antioxidant Vitamin Supplements: the Cache County Study. Arch Neurol. 2004;61(1):82-8. PubMed PMID: 14732624.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. AU - Zandi,Peter P, AU - Anthony,James C, AU - Khachaturian,Ara S, AU - Stone,Stephanie V, AU - Gustafson,Deborah, AU - Tschanz,JoAnn T, AU - Norton,Maria C, AU - Welsh-Bohmer,Kathleen A, AU - Breitner,John C S, AU - ,, PY - 2004/1/21/pubmed PY - 2004/2/26/medline PY - 2004/1/21/entrez SP - 82 EP - 8 JF - Archives of neurology JO - Arch. Neurol. VL - 61 IS - 1 N2 - BACKGROUND: Antioxidants may protect the aging brain against oxidative damage associated with pathological changes of Alzheimer disease (AD). OBJECTIVE: To examine the relationship between antioxidant supplement use and risk of AD. DESIGN: Cross-sectional and prospective study of dementia. Elderly (65 years or older) county residents were assessed in 1995 to 1997 for prevalent dementia and AD, and again in 1998 to 2000 for incident illness. Supplement use was ascertained at the first contact. SETTING: Cache County, Utah. PARTICIPANTS: Among 4740 respondents (93%) with data sufficient to determine cognitive status at the initial assessment, we identified 200 prevalent cases of AD. Among 3227 survivors at risk, we identified 104 incident AD cases at follow-up. MAIN OUTCOME MEASURE: Diagnosis of AD by means of multistage assessment procedures. RESULTS: Analyses of prevalent and incident AD yielded similar results. Use of vitamin E and C (ascorbic acid) supplements in combination was associated with reduced AD prevalence (adjusted odds ratio, 0.22; 95% confidence interval, 0.05-0.60) and incidence (adjusted hazard ratio, 0.36; 95% confidence interval, 0.09-0.99). A trend toward lower AD risk was also evident in users of vitamin E and multivitamins containing vitamin C, but we saw no evidence of a protective effect with use of vitamin E or vitamin C supplements alone, with multivitamins alone, or with vitamin B-complex supplements. CONCLUSIONS: Use of vitamin E and vitamin C supplements in combination is associated with reduced prevalence and incidence of AD. Antioxidant supplements merit further study as agents for the primary prevention of AD. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/14732624/Reduced_risk_of_Alzheimer_disease_in_users_of_antioxidant_vitamin_supplements:_the_Cache_County_Study_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.61.1.82 DB - PRIME DP - Unbound Medicine ER -