Tags

Type your tag names separated by a space and hit enter

Neural inhibition of inflammation: the cholinergic anti-inflammatory pathway.
J Endotoxin Res. 2003; 9(6):409-13.JE

Abstract

The innate immune system is activated by infection and injury to release pro-inflammatory cytokines, which activate macrophages and neutrophils and modulate specific cellular responses. The magnitude of the cytokine response is critical, because a deficient response may result in secondary infections, while an excessive response may be more injurious than the original insult. We recently described a neural pathway, termed the "cholinergic anti-inflammatory pathway", that reflexively monitors and adjusts the inflammatory response by inhibiting pro-inflammatory cytokine synthesis. Efferent signals in the vagus nerve provide a direct mechanism for neural regulation of the immune response that is rapid, localized, and integrated. Vagus nerve stimulation inhibits the release of TNF, HMGB1, and other cytokines, and protects against endotoxemia and ischemia-reperfusion injury. This newly identified physiological mechanism of maintaining immunological homeostasis suggests that novel therapeutics may effectively modulate inflammatory responses by activating the cholinergic anti-inflammatory pathway.

Authors+Show Affiliations

Laboratory of Biomedical Science, North Shore-LIJ Research Institute, Manhasset, NY 11030, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

14733730

Citation

Czura, Christopher J., et al. "Neural Inhibition of Inflammation: the Cholinergic Anti-inflammatory Pathway." Journal of Endotoxin Research, vol. 9, no. 6, 2003, pp. 409-13.
Czura CJ, Friedman SG, Tracey KJ. Neural inhibition of inflammation: the cholinergic anti-inflammatory pathway. J Endotoxin Res. 2003;9(6):409-13.
Czura, C. J., Friedman, S. G., & Tracey, K. J. (2003). Neural inhibition of inflammation: the cholinergic anti-inflammatory pathway. Journal of Endotoxin Research, 9(6), 409-13.
Czura CJ, Friedman SG, Tracey KJ. Neural Inhibition of Inflammation: the Cholinergic Anti-inflammatory Pathway. J Endotoxin Res. 2003;9(6):409-13. PubMed PMID: 14733730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neural inhibition of inflammation: the cholinergic anti-inflammatory pathway. AU - Czura,Christopher J, AU - Friedman,Steven G, AU - Tracey,Kevin J, PY - 2004/1/22/pubmed PY - 2004/8/18/medline PY - 2004/1/22/entrez SP - 409 EP - 13 JF - Journal of endotoxin research JO - J Endotoxin Res VL - 9 IS - 6 N2 - The innate immune system is activated by infection and injury to release pro-inflammatory cytokines, which activate macrophages and neutrophils and modulate specific cellular responses. The magnitude of the cytokine response is critical, because a deficient response may result in secondary infections, while an excessive response may be more injurious than the original insult. We recently described a neural pathway, termed the "cholinergic anti-inflammatory pathway", that reflexively monitors and adjusts the inflammatory response by inhibiting pro-inflammatory cytokine synthesis. Efferent signals in the vagus nerve provide a direct mechanism for neural regulation of the immune response that is rapid, localized, and integrated. Vagus nerve stimulation inhibits the release of TNF, HMGB1, and other cytokines, and protects against endotoxemia and ischemia-reperfusion injury. This newly identified physiological mechanism of maintaining immunological homeostasis suggests that novel therapeutics may effectively modulate inflammatory responses by activating the cholinergic anti-inflammatory pathway. SN - 0968-0519 UR - https://www.unboundmedicine.com/medline/citation/14733730/Neural_inhibition_of_inflammation:_the_cholinergic_anti_inflammatory_pathway_ DB - PRIME DP - Unbound Medicine ER -