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Genome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians.
Genes Immun. 2004 Jan; 5(1):63-7.GI

Abstract

Genome-wide scans were conducted for tuberculosis and leprosy per se in Brazil. At stage 1, 405 markers (10 cM map) were typed in 16 (178 individuals) tuberculosis and 21 (173 individuals) leprosy families. Nonparametric multipoint analysis detected 8 and 9 chromosomal regions respectively with provisional evidence (P<0.05) for linkage. At stage 2, 58 markers from positive regions were typed in a second set of 22 (176 individuals) tuberculosis families, with 22 additional markers typed in all families; 42 positive markers in 50 (192 individuals) new leprosy families, and 30 additional markers in all families. Three regions (10q26.13, 11q12.3, 20p12.1) retained suggestive evidence (peak LOD scores 1.31, 1.85, 1.78; P=0.007, 0.0018, 0.0021) for linkage to tuberculosis, 3 regions (6p21.32, 17q22, 20p13) to leprosy (HLA-DQA, 3.23, P=5.8 x 10(-5); D17S1868, 2.38, P=0.0005; D20S889, 1.51, P=0.004). The peak at D20S889 for leprosy is 3.5 Mb distal to that reported at D20S115 for leprosy in India. (151 words).

Authors+Show Affiliations

Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, University of Cambridge School of Clinical Medicine, Addenbrookes Hospital, Hills Road, Cambridge CB2 2XY, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14735151

Citation

Miller, E N., et al. "Genome-wide Scans for Leprosy and Tuberculosis Susceptibility Genes in Brazilians." Genes and Immunity, vol. 5, no. 1, 2004, pp. 63-7.
Miller EN, Jamieson SE, Joberty C, et al. Genome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians. Genes Immun. 2004;5(1):63-7.
Miller, E. N., Jamieson, S. E., Joberty, C., Fakiola, M., Hudson, D., Peacock, C. S., Cordell, H. J., Shaw, M. A., Lins-Lainson, Z., Shaw, J. J., Ramos, F., Silveira, F., & Blackwell, J. M. (2004). Genome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians. Genes and Immunity, 5(1), 63-7.
Miller EN, et al. Genome-wide Scans for Leprosy and Tuberculosis Susceptibility Genes in Brazilians. Genes Immun. 2004;5(1):63-7. PubMed PMID: 14735151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians. AU - Miller,E N, AU - Jamieson,S E, AU - Joberty,C, AU - Fakiola,M, AU - Hudson,D, AU - Peacock,C S, AU - Cordell,H J, AU - Shaw,M-A, AU - Lins-Lainson,Z, AU - Shaw,J J, AU - Ramos,F, AU - Silveira,F, AU - Blackwell,J M, PY - 2004/1/22/pubmed PY - 2004/9/29/medline PY - 2004/1/22/entrez SP - 63 EP - 7 JF - Genes and immunity JO - Genes Immun. VL - 5 IS - 1 N2 - Genome-wide scans were conducted for tuberculosis and leprosy per se in Brazil. At stage 1, 405 markers (10 cM map) were typed in 16 (178 individuals) tuberculosis and 21 (173 individuals) leprosy families. Nonparametric multipoint analysis detected 8 and 9 chromosomal regions respectively with provisional evidence (P<0.05) for linkage. At stage 2, 58 markers from positive regions were typed in a second set of 22 (176 individuals) tuberculosis families, with 22 additional markers typed in all families; 42 positive markers in 50 (192 individuals) new leprosy families, and 30 additional markers in all families. Three regions (10q26.13, 11q12.3, 20p12.1) retained suggestive evidence (peak LOD scores 1.31, 1.85, 1.78; P=0.007, 0.0018, 0.0021) for linkage to tuberculosis, 3 regions (6p21.32, 17q22, 20p13) to leprosy (HLA-DQA, 3.23, P=5.8 x 10(-5); D17S1868, 2.38, P=0.0005; D20S889, 1.51, P=0.004). The peak at D20S889 for leprosy is 3.5 Mb distal to that reported at D20S115 for leprosy in India. (151 words). SN - 1466-4879 UR - https://www.unboundmedicine.com/medline/citation/14735151/Genome_wide_scans_for_leprosy_and_tuberculosis_susceptibility_genes_in_Brazilians_ L2 - http://dx.doi.org/10.1038/sj.gene.6364031 DB - PRIME DP - Unbound Medicine ER -