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Fruits and vegetables and prostate cancer: no association among 1104 cases in a prospective study of 130544 men in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Abstract

We examined the association between self-reported consumption of fruits and vegetables and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Data on food consumption and complete follow-up for cancer incidence were available for 130544 men in 7 countries recruited into EPIC between 1993 and 1999. After an average of 4.8 years of follow-up, there were 1104 incident cases of prostate cancer. The associations of consumption of total fruits, total vegetables, cruciferous vegetables and combined total fruits and vegetables with prostate cancer risk were examined using Cox regression, stratified for recruitment center and adjusted for height, weight and energy intake. There was a wide range in consumption of fruits and vegetables: mean intakes (g/day) in the bottom and top fifths of the distribution, as estimated from 24-hr recalls in a subsample of participants, were 53.2 and 410.7 for fruits, 97.1 and 242.1 for vegetables and 169.0 and 633.7 for fruits and vegetables combined. No significant associations between fruit and vegetable consumption and prostate cancer risk were observed. Relative risks (95% confidence intervals) in the top fifth of the distribution of consumption, compared to the bottom fifth, were 1.06 (0.84-1.34) for total fruits, 1.00 (0.81-1.22) for total vegetables and 1.00 (0.79-1.26) for total fruits and vegetables combined; intake of cruciferous vegetables was not associated with risk. These results suggest that total consumption of fruits and vegetables is not associated with the risk for prostate cancer.

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  • Authors+Show Affiliations

    ,

    Cancer Research U.K. Epidemiology Unit, University of Oxford, Oxford, United Kingdom. tim.key@cancer.org.uk

    , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

    Source

    International journal of cancer 109:1 2004 Mar pg 119-24

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Diet
    Fruit
    Humans
    Male
    Middle Aged
    Models, Genetic
    Nutritional Status
    Proportional Hazards Models
    Prospective Studies
    Prostatic Neoplasms
    Risk
    Risk Factors
    Time Factors
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14735477

    Citation

    Key, Timothy J., et al. "Fruits and Vegetables and Prostate Cancer: No Association Among 1104 Cases in a Prospective Study of 130544 Men in the European Prospective Investigation Into Cancer and Nutrition (EPIC)." International Journal of Cancer, vol. 109, no. 1, 2004, pp. 119-24.
    Key TJ, Allen N, Appleby P, et al. Fruits and vegetables and prostate cancer: no association among 1104 cases in a prospective study of 130544 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer. 2004;109(1):119-24.
    Key, T. J., Allen, N., Appleby, P., Overvad, K., Tjønneland, A., Miller, A., ... Riboli, E. (2004). Fruits and vegetables and prostate cancer: no association among 1104 cases in a prospective study of 130544 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). International Journal of Cancer, 109(1), pp. 119-24.
    Key TJ, et al. Fruits and Vegetables and Prostate Cancer: No Association Among 1104 Cases in a Prospective Study of 130544 Men in the European Prospective Investigation Into Cancer and Nutrition (EPIC). Int J Cancer. 2004;109(1):119-24. PubMed PMID: 14735477.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fruits and vegetables and prostate cancer: no association among 1104 cases in a prospective study of 130544 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). AU - Key,Timothy J, AU - Allen,Naomi, AU - Appleby,Paul, AU - Overvad,Kim, AU - Tjønneland,Anne, AU - Miller,Anthony, AU - Boeing,Heiner, AU - Karalis,Dimitrios, AU - Psaltopoulou,Theodora, AU - Berrino,Franco, AU - Palli,Domenico, AU - Panico,Salvatore, AU - Tumino,Rosario, AU - Vineis,Paolo, AU - Bueno-De-Mesquita,H B, AU - Kiemeney,Lambertus, AU - Peeters,Petra H M, AU - Martinez,Carmen, AU - Dorronsoro,Miren, AU - González,Carlos A, AU - Chirlaque,M D, AU - Quiros,J Ramon, AU - Ardanaz,Eva, AU - Berglund,Göran, AU - Egevad,Lars, AU - Hallmans,Göran, AU - Stattin,Pär, AU - Bingham,Sheila, AU - Day,Nicholas, AU - Gann,Peter, AU - Kaaks,Rudolf, AU - Ferrari,Pietro, AU - Riboli,Elio, AU - ,, PY - 2004/1/22/pubmed PY - 2004/3/16/medline PY - 2004/1/22/entrez SP - 119 EP - 24 JF - International journal of cancer JO - Int. J. Cancer VL - 109 IS - 1 N2 - We examined the association between self-reported consumption of fruits and vegetables and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Data on food consumption and complete follow-up for cancer incidence were available for 130544 men in 7 countries recruited into EPIC between 1993 and 1999. After an average of 4.8 years of follow-up, there were 1104 incident cases of prostate cancer. The associations of consumption of total fruits, total vegetables, cruciferous vegetables and combined total fruits and vegetables with prostate cancer risk were examined using Cox regression, stratified for recruitment center and adjusted for height, weight and energy intake. There was a wide range in consumption of fruits and vegetables: mean intakes (g/day) in the bottom and top fifths of the distribution, as estimated from 24-hr recalls in a subsample of participants, were 53.2 and 410.7 for fruits, 97.1 and 242.1 for vegetables and 169.0 and 633.7 for fruits and vegetables combined. No significant associations between fruit and vegetable consumption and prostate cancer risk were observed. Relative risks (95% confidence intervals) in the top fifth of the distribution of consumption, compared to the bottom fifth, were 1.06 (0.84-1.34) for total fruits, 1.00 (0.81-1.22) for total vegetables and 1.00 (0.79-1.26) for total fruits and vegetables combined; intake of cruciferous vegetables was not associated with risk. These results suggest that total consumption of fruits and vegetables is not associated with the risk for prostate cancer. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/14735477/Fruits_and_vegetables_and_prostate_cancer:_no_association_among_1104_cases_in_a_prospective_study_of_130544_men_in_the_European_Prospective_Investigation_into_Cancer_and_Nutrition__EPIC__ L2 - https://doi.org/10.1002/ijc.11671 DB - PRIME DP - Unbound Medicine ER -