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Evidence for the presence of 5-HT1B receptor messenger RNA in neurons of the rat trigeminal ganglia.
Eur J Pharmacol. 1992 Nov 02; 227(3):357-9.EJ

Abstract

In situ hybridization histochemistry and receptor autoradiography were used to determine the presence of 5-HT1B receptor messenger RNA (mRNA) and 5-HT1B receptor proteins, respectively, in rat trigeminal ganglia. Receptor autoradiography on rat trigeminal ganglia, using appropriate 5-HT1B radioligands, did not demonstrate any specific labelling. In contrast, in situ hybridization showed that many ganglion cells contain 5-HT1B receptor mRNA, suggesting the presence of presynaptic 5-HT1B receptors on trigeminovascular neurons.

Authors+Show Affiliations

Sandoz Pharma Ltd., Basle, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1473558

Citation

Bruinvels, A T., et al. "Evidence for the Presence of 5-HT1B Receptor Messenger RNA in Neurons of the Rat Trigeminal Ganglia." European Journal of Pharmacology, vol. 227, no. 3, 1992, pp. 357-9.
Bruinvels AT, Landwehrmeyer B, Moskowitz MA, et al. Evidence for the presence of 5-HT1B receptor messenger RNA in neurons of the rat trigeminal ganglia. Eur J Pharmacol. 1992;227(3):357-9.
Bruinvels, A. T., Landwehrmeyer, B., Moskowitz, M. A., & Hoyer, D. (1992). Evidence for the presence of 5-HT1B receptor messenger RNA in neurons of the rat trigeminal ganglia. European Journal of Pharmacology, 227(3), 357-9.
Bruinvels AT, et al. Evidence for the Presence of 5-HT1B Receptor Messenger RNA in Neurons of the Rat Trigeminal Ganglia. Eur J Pharmacol. 1992 Nov 2;227(3):357-9. PubMed PMID: 1473558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for the presence of 5-HT1B receptor messenger RNA in neurons of the rat trigeminal ganglia. AU - Bruinvels,A T, AU - Landwehrmeyer,B, AU - Moskowitz,M A, AU - Hoyer,D, PY - 1992/11/2/pubmed PY - 1992/11/2/medline PY - 1992/11/2/entrez SP - 357 EP - 9 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 227 IS - 3 N2 - In situ hybridization histochemistry and receptor autoradiography were used to determine the presence of 5-HT1B receptor messenger RNA (mRNA) and 5-HT1B receptor proteins, respectively, in rat trigeminal ganglia. Receptor autoradiography on rat trigeminal ganglia, using appropriate 5-HT1B radioligands, did not demonstrate any specific labelling. In contrast, in situ hybridization showed that many ganglion cells contain 5-HT1B receptor mRNA, suggesting the presence of presynaptic 5-HT1B receptors on trigeminovascular neurons. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/1473558/Evidence_for_the_presence_of_5_HT1B_receptor_messenger_RNA_in_neurons_of_the_rat_trigeminal_ganglia_ DB - PRIME DP - Unbound Medicine ER -