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On line continuous monitoring of subcutaneous tissue glucose in men by combining portable glucosensor with microdialysis.
Diabetologia. 1992 Nov; 35(11):1087-92.D

Abstract

For the normalisation of blood glucose levels in diabetic patients by feedback controlled insulin delivery, a self-manageable and reliable method for continuous glucose estimation is still not available. By combining a commercially available needle type dialysis probe (molecular cutoff 20,000 Da) with a sensitive glucose sensor, we obtained a device for continuous glucose measurement in dialysate. This device was tested in healthy volunteers during a 75-g oral glucose tolerance test and in Type 2 (non-insulin-dependent) diabetic patients. Venous glucose and subcutaneous sensor signal were followed for 300 min (ten healthy subjects), 21 h (three healthy subjects) or 9 h (seven Type 2 diabetic patients). The recovery of the microdialysis was interindividually different, but after calibration, glucose levels in the dialysate and subcutaneous glucose sensor signal correlated well (r = 0.84-0.95). Under the assumption of a physiologic and technical delay between intravenous and subcutaneous glucose, correlation coefficient between intravenous glucose and subcutaneous sensor signal ranged from 0.60 to 0.93. We conclude that changes in blood glucose could be monitored in the subcutaneous tissue by the microdialysis technique in a continuous on line manner.

Authors+Show Affiliations

Institut für Diabetes Technologie, Universität Ulm, FRG.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1473620

Citation

Meyerhoff, C, et al. "On Line Continuous Monitoring of Subcutaneous Tissue Glucose in Men By Combining Portable Glucosensor With Microdialysis." Diabetologia, vol. 35, no. 11, 1992, pp. 1087-92.
Meyerhoff C, Bischof F, Sternberg F, et al. On line continuous monitoring of subcutaneous tissue glucose in men by combining portable glucosensor with microdialysis. Diabetologia. 1992;35(11):1087-92.
Meyerhoff, C., Bischof, F., Sternberg, F., Zier, H., & Pfeiffer, E. F. (1992). On line continuous monitoring of subcutaneous tissue glucose in men by combining portable glucosensor with microdialysis. Diabetologia, 35(11), 1087-92.
Meyerhoff C, et al. On Line Continuous Monitoring of Subcutaneous Tissue Glucose in Men By Combining Portable Glucosensor With Microdialysis. Diabetologia. 1992;35(11):1087-92. PubMed PMID: 1473620.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - On line continuous monitoring of subcutaneous tissue glucose in men by combining portable glucosensor with microdialysis. AU - Meyerhoff,C, AU - Bischof,F, AU - Sternberg,F, AU - Zier,H, AU - Pfeiffer,E F, PY - 1992/11/1/pubmed PY - 1992/11/1/medline PY - 1992/11/1/entrez SP - 1087 EP - 92 JF - Diabetologia JO - Diabetologia VL - 35 IS - 11 N2 - For the normalisation of blood glucose levels in diabetic patients by feedback controlled insulin delivery, a self-manageable and reliable method for continuous glucose estimation is still not available. By combining a commercially available needle type dialysis probe (molecular cutoff 20,000 Da) with a sensitive glucose sensor, we obtained a device for continuous glucose measurement in dialysate. This device was tested in healthy volunteers during a 75-g oral glucose tolerance test and in Type 2 (non-insulin-dependent) diabetic patients. Venous glucose and subcutaneous sensor signal were followed for 300 min (ten healthy subjects), 21 h (three healthy subjects) or 9 h (seven Type 2 diabetic patients). The recovery of the microdialysis was interindividually different, but after calibration, glucose levels in the dialysate and subcutaneous glucose sensor signal correlated well (r = 0.84-0.95). Under the assumption of a physiologic and technical delay between intravenous and subcutaneous glucose, correlation coefficient between intravenous glucose and subcutaneous sensor signal ranged from 0.60 to 0.93. We conclude that changes in blood glucose could be monitored in the subcutaneous tissue by the microdialysis technique in a continuous on line manner. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/1473620/On_line_continuous_monitoring_of_subcutaneous_tissue_glucose_in_men_by_combining_portable_glucosensor_with_microdialysis_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:1473620 DB - PRIME DP - Unbound Medicine ER -