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Tetrahydrofuran lignans from Nectandra megapotamica with trypanocidal activity.
J Nat Prod. 2004 Jan; 67(1):42-5.JN

Abstract

The phytochemical investigation of the crude ethanol extract of the leaves of Nectandra megapotamica afforded three new (2d, 3b, and 3c) and eight known (1a-d, 2a-c, and 3a) tetrahydrofuran lignans. Regarding the in vitro trypanocidal activity, the lignan-rich fraction, at a concentration of 2.0 mg/mL, was 100% active. Compound 1a was the most active, showing an IC(50) value of 2.2 microM and lysis of 94% of the parasites at 32 microM. Compounds 1b, 1d, 2a, 2c, and 3a displayed moderate activity, while compound 1c was inactive.

Authors+Show Affiliations

da Silva Filho AA
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café S/N, Ribeirão Preto 14040-903, SP, Brazil.
Albuquerque S
No affiliation info available
Silva ML
No affiliation info available
Eberlin MN
No affiliation info available
Tomazela DM
No affiliation info available
Bastos JK
No affiliation info available

MeSH

AnimalsBrazilFuransInhibitory Concentration 50LauraceaeLignansMolecular StructureNuclear Magnetic Resonance, BiomolecularPlant LeavesPlants, MedicinalStereoisomerismStructure-Activity RelationshipTrypanocidal AgentsTrypanosoma cruzi

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14738383

Citation

da Silva Filho, Ademar A., et al. "Tetrahydrofuran Lignans From Nectandra Megapotamica With Trypanocidal Activity." Journal of Natural Products, vol. 67, no. 1, 2004, pp. 42-5.
da Silva Filho AA, Albuquerque S, Silva ML, et al. Tetrahydrofuran lignans from Nectandra megapotamica with trypanocidal activity. J Nat Prod. 2004;67(1):42-5.
da Silva Filho, A. A., Albuquerque, S., Silva, M. L., Eberlin, M. N., Tomazela, D. M., & Bastos, J. K. (2004). Tetrahydrofuran lignans from Nectandra megapotamica with trypanocidal activity. Journal of Natural Products, 67(1), 42-5.
da Silva Filho AA, et al. Tetrahydrofuran Lignans From Nectandra Megapotamica With Trypanocidal Activity. J Nat Prod. 2004;67(1):42-5. PubMed PMID: 14738383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tetrahydrofuran lignans from Nectandra megapotamica with trypanocidal activity. AU - da Silva Filho,Ademar A, AU - Albuquerque,Sérgio, AU - Silva,Márcio L A e, AU - Eberlin,Marcos N, AU - Tomazela,Daniela M, AU - Bastos,Jairo K, PY - 2004/1/24/pubmed PY - 2004/5/27/medline PY - 2004/1/24/entrez SP - 42 EP - 5 JF - Journal of natural products JO - J Nat Prod VL - 67 IS - 1 N2 - The phytochemical investigation of the crude ethanol extract of the leaves of Nectandra megapotamica afforded three new (2d, 3b, and 3c) and eight known (1a-d, 2a-c, and 3a) tetrahydrofuran lignans. Regarding the in vitro trypanocidal activity, the lignan-rich fraction, at a concentration of 2.0 mg/mL, was 100% active. Compound 1a was the most active, showing an IC(50) value of 2.2 microM and lysis of 94% of the parasites at 32 microM. Compounds 1b, 1d, 2a, 2c, and 3a displayed moderate activity, while compound 1c was inactive. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/14738383/Tetrahydrofuran_lignans_from_Nectandra_megapotamica_with_trypanocidal_activity_ DB - PRIME DP - Unbound Medicine ER -