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Low plasma level of adiponectin is associated with stavudine treatment and lipodystrophy in HIV-infected patients.
Clin Exp Immunol 2004; 135(2):273-9CE

Abstract

This study tested the hypothesis that in patients with HIV-associated lipodystrophy, adiponectin levels were related to insulin resistance, TNF-alpha and IL-6 and treatment with nucleoside analogues. HIV seropositive men undergoing highly active antiretroviral treatment were enrolled into three predetermined clinical groups: lipodystrophy with central fat accumulation (n = 12); lipodystrophy without central fat accumulation (n = 15); no lipodystrophy (n = 15). HIV-negative healthy men served as controls (n = 12). Both lipodystrophic groups had a low percentage of limb fat compared to the two control groups. Patients with lipodystrophy with fat accumulation had increased truncal fat compared with controls. Levels of adiponectin did not correlate with either TNF-alpha or IL-6. Low levels of adiponectin were found in both lipodystrophic groups and were associated with current or previous treatment with stavudine. Furthermore, the adiponectin level correlated with the percentage of limb fat. Patients with lipodystrophy with fat accumulation were more insulin resistant, measured by HOMA-IR, compared with controls. However, HOMA-IR did no correlate to adiponectin or other cytokines. In conclusion, the finding of no difference between the two lipodystrophic groups with regard to adiponectin, indicates that low levels of adiponectin reflects fat atrophy, whereas the insulin resistance was best explained by increased truncal fat mass.

Authors+Show Affiliations

Department of Infectious Diseases, University of Copenhagen, Denmark. blm@rh.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14738456

Citation

Lindegaard, B, et al. "Low Plasma Level of Adiponectin Is Associated With Stavudine Treatment and Lipodystrophy in HIV-infected Patients." Clinical and Experimental Immunology, vol. 135, no. 2, 2004, pp. 273-9.
Lindegaard B, Keller P, Bruunsgaard H, et al. Low plasma level of adiponectin is associated with stavudine treatment and lipodystrophy in HIV-infected patients. Clin Exp Immunol. 2004;135(2):273-9.
Lindegaard, B., Keller, P., Bruunsgaard, H., Gerstoft, J., & Pedersen, B. K. (2004). Low plasma level of adiponectin is associated with stavudine treatment and lipodystrophy in HIV-infected patients. Clinical and Experimental Immunology, 135(2), pp. 273-9.
Lindegaard B, et al. Low Plasma Level of Adiponectin Is Associated With Stavudine Treatment and Lipodystrophy in HIV-infected Patients. Clin Exp Immunol. 2004;135(2):273-9. PubMed PMID: 14738456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low plasma level of adiponectin is associated with stavudine treatment and lipodystrophy in HIV-infected patients. AU - Lindegaard,B, AU - Keller,P, AU - Bruunsgaard,H, AU - Gerstoft,J, AU - Pedersen,B K, PY - 2004/1/24/pubmed PY - 2004/3/11/medline PY - 2004/1/24/entrez SP - 273 EP - 9 JF - Clinical and experimental immunology JO - Clin. Exp. Immunol. VL - 135 IS - 2 N2 - This study tested the hypothesis that in patients with HIV-associated lipodystrophy, adiponectin levels were related to insulin resistance, TNF-alpha and IL-6 and treatment with nucleoside analogues. HIV seropositive men undergoing highly active antiretroviral treatment were enrolled into three predetermined clinical groups: lipodystrophy with central fat accumulation (n = 12); lipodystrophy without central fat accumulation (n = 15); no lipodystrophy (n = 15). HIV-negative healthy men served as controls (n = 12). Both lipodystrophic groups had a low percentage of limb fat compared to the two control groups. Patients with lipodystrophy with fat accumulation had increased truncal fat compared with controls. Levels of adiponectin did not correlate with either TNF-alpha or IL-6. Low levels of adiponectin were found in both lipodystrophic groups and were associated with current or previous treatment with stavudine. Furthermore, the adiponectin level correlated with the percentage of limb fat. Patients with lipodystrophy with fat accumulation were more insulin resistant, measured by HOMA-IR, compared with controls. However, HOMA-IR did no correlate to adiponectin or other cytokines. In conclusion, the finding of no difference between the two lipodystrophic groups with regard to adiponectin, indicates that low levels of adiponectin reflects fat atrophy, whereas the insulin resistance was best explained by increased truncal fat mass. SN - 0009-9104 UR - https://www.unboundmedicine.com/medline/citation/14738456/Low_plasma_level_of_adiponectin_is_associated_with_stavudine_treatment_and_lipodystrophy_in_HIV_infected_patients_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0009-9104&date=2004&volume=135&issue=2&spage=273 DB - PRIME DP - Unbound Medicine ER -