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Changes in dietary fat intake alter plasma levels of oxidized low-density lipoprotein and lipoprotein(a).
Arterioscler Thromb Vasc Biol 2004; 24(3):498-503AT

Abstract

OBJECTIVE

To assess the effects of dietary modifications on oxidized low-density lipoprotein (LDL).

METHODS AND RESULTS

Thirty-seven healthy women were fed two diets. Both diets contained a reduced amount of total and saturated fat. In addition, one diet was low in vegetables and the other was high in vegetables, berries, and fruit. The dietary intake of total fat was 70 g per day at baseline and decreased to 56 g (low-fat, low-vegetable diet) and to 59 g (low-fat, high-vegetable diet). The saturated fat intake decreased from 28 g to 20 g and to 19 g, and the amount of polyunsaturated fat intake increased from 11 g to 13 g and to 19 g (baseline; low-fat, low-vegetable; low-fat, high-vegetable; respectively). The amount of oxidized LDL in plasma was determined as the content of oxidized phospholipid per ApoB-100 using a monoclonal antibody EO6 (OxLDL-EO6). The median plasma OxLDL-EO6 increased by 27% (P<0.01) in response to the low-fat, low-vegetable diet and 19% (P<0.01) in response to the low-fat, high-vegetable diet. Also, the Lp(a) concentration was increased by 7% (P<0.01) and 9% (P=0.01), respectively.

CONCLUSIONS

Alterations in the dietary fat intake resulted in increased plasma concentrations of lipoprotein(a) and OxLDL-EO6.

Authors+Show Affiliations

Department of Internal Medicine and Biocenter Oulu, University of Oulu, Finland. Marja-Leena.Silaste@oulu.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

14739118

Citation

Silaste, Marja-Leena, et al. "Changes in Dietary Fat Intake Alter Plasma Levels of Oxidized Low-density Lipoprotein and Lipoprotein(a)." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 3, 2004, pp. 498-503.
Silaste ML, Rantala M, Alfthan G, et al. Changes in dietary fat intake alter plasma levels of oxidized low-density lipoprotein and lipoprotein(a). Arterioscler Thromb Vasc Biol. 2004;24(3):498-503.
Silaste, M. L., Rantala, M., Alfthan, G., Aro, A., Witztum, J. L., Kesäniemi, Y. A., & Hörkkö, S. (2004). Changes in dietary fat intake alter plasma levels of oxidized low-density lipoprotein and lipoprotein(a). Arteriosclerosis, Thrombosis, and Vascular Biology, 24(3), pp. 498-503.
Silaste ML, et al. Changes in Dietary Fat Intake Alter Plasma Levels of Oxidized Low-density Lipoprotein and Lipoprotein(a). Arterioscler Thromb Vasc Biol. 2004;24(3):498-503. PubMed PMID: 14739118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in dietary fat intake alter plasma levels of oxidized low-density lipoprotein and lipoprotein(a). AU - Silaste,Marja-Leena, AU - Rantala,Maire, AU - Alfthan,Georg, AU - Aro,Antti, AU - Witztum,Joseph L, AU - Kesäniemi,Y Antero, AU - Hörkkö,Sohvi, Y1 - 2004/01/22/ PY - 2004/1/24/pubmed PY - 2005/1/5/medline PY - 2004/1/24/entrez SP - 498 EP - 503 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 24 IS - 3 N2 - OBJECTIVE: To assess the effects of dietary modifications on oxidized low-density lipoprotein (LDL). METHODS AND RESULTS: Thirty-seven healthy women were fed two diets. Both diets contained a reduced amount of total and saturated fat. In addition, one diet was low in vegetables and the other was high in vegetables, berries, and fruit. The dietary intake of total fat was 70 g per day at baseline and decreased to 56 g (low-fat, low-vegetable diet) and to 59 g (low-fat, high-vegetable diet). The saturated fat intake decreased from 28 g to 20 g and to 19 g, and the amount of polyunsaturated fat intake increased from 11 g to 13 g and to 19 g (baseline; low-fat, low-vegetable; low-fat, high-vegetable; respectively). The amount of oxidized LDL in plasma was determined as the content of oxidized phospholipid per ApoB-100 using a monoclonal antibody EO6 (OxLDL-EO6). The median plasma OxLDL-EO6 increased by 27% (P<0.01) in response to the low-fat, low-vegetable diet and 19% (P<0.01) in response to the low-fat, high-vegetable diet. Also, the Lp(a) concentration was increased by 7% (P<0.01) and 9% (P=0.01), respectively. CONCLUSIONS: Alterations in the dietary fat intake resulted in increased plasma concentrations of lipoprotein(a) and OxLDL-EO6. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/14739118/Changes_in_dietary_fat_intake_alter_plasma_levels_of_oxidized_low_density_lipoprotein_and_lipoprotein_a__ L2 - http://www.ahajournals.org/doi/full/10.1161/01.ATV.0000118012.64932.f4?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -