Tags

Type your tag names separated by a space and hit enter

Deleterious impact of "high normal" glucose levels and other metabolic syndrome components on arterial endothelial function and intima-media thickness in apparently healthy Chinese subjects: the CATHAY study.
Arterioscler Thromb Vasc Biol. 2004 Apr; 24(4):739-43.AT

Abstract

OBJECTIVE

Endothelial vasodilator dysfunction and carotid intima-media thickening are useful surrogate markers of cardiovascular disease, a major cause of morbidity and mortality in type 2 diabetic patients. However, because most studies reporting the relationships between endothelial function, intima-media thickness (IMT), and hyperglycemia have compared diabetic patients with healthy controls, we report their relationship with glycemia as a continuum.

METHODS AND RESULTS

Brachial artery endothelial function (flow-mediated dilatation [FMD]) and carotid IMT were measured noninvasively by high-resolution ultrasound B-mode imaging in 228 apparently healthy Chinese subjects recruited from Hong Kong and Macau. FMD and IMT were significantly associated with increasing levels of glycemia, particularly in the "high normal" glycemic range, with IMT increasing and endothelium-independent dilatation decreasing linearly across the glucose tertiles, and endothelium-dependent dilatation significantly lower in the upper glucose tertile compared with the other 2 groups (P<0.01). Using multiple linear regression, fasting glucose level was identified as an independent predictor of each of these markers of vascular function (P<0.004). Additionally, other conventional cardiovascular risk factors, including obesity, blood pressure, and an adverse lipid profile, were also related to levels of glycemia (P<0.05), further contributing to impaired vascular function.

CONCLUSIONS

Increasing levels of glycemia and the coexistence of other cardiovascular risk factors in apparently healthy subjects are adversely associated with arterial endothelial dysfunction and intima-media thickening.

Authors+Show Affiliations

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14739120

Citation

Thomas, G Neil, et al. "Deleterious Impact of "high Normal" Glucose Levels and Other Metabolic Syndrome Components On Arterial Endothelial Function and Intima-media Thickness in Apparently Healthy Chinese Subjects: the CATHAY Study." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 4, 2004, pp. 739-43.
Thomas GN, Chook P, Qiao M, et al. Deleterious impact of "high normal" glucose levels and other metabolic syndrome components on arterial endothelial function and intima-media thickness in apparently healthy Chinese subjects: the CATHAY study. Arterioscler Thromb Vasc Biol. 2004;24(4):739-43.
Thomas, G. N., Chook, P., Qiao, M., Huang, X. S., Leong, H. C., Celermajer, D. S., & Woo, K. S. (2004). Deleterious impact of "high normal" glucose levels and other metabolic syndrome components on arterial endothelial function and intima-media thickness in apparently healthy Chinese subjects: the CATHAY study. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(4), 739-43.
Thomas GN, et al. Deleterious Impact of "high Normal" Glucose Levels and Other Metabolic Syndrome Components On Arterial Endothelial Function and Intima-media Thickness in Apparently Healthy Chinese Subjects: the CATHAY Study. Arterioscler Thromb Vasc Biol. 2004;24(4):739-43. PubMed PMID: 14739120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deleterious impact of "high normal" glucose levels and other metabolic syndrome components on arterial endothelial function and intima-media thickness in apparently healthy Chinese subjects: the CATHAY study. AU - Thomas,G Neil, AU - Chook,Ping, AU - Qiao,Mu, AU - Huang,Xin S, AU - Leong,Hok C, AU - Celermajer,David S, AU - Woo,Kam S, Y1 - 2004/01/22/ PY - 2004/1/24/pubmed PY - 2004/8/6/medline PY - 2004/1/24/entrez SP - 739 EP - 43 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler Thromb Vasc Biol VL - 24 IS - 4 N2 - OBJECTIVE: Endothelial vasodilator dysfunction and carotid intima-media thickening are useful surrogate markers of cardiovascular disease, a major cause of morbidity and mortality in type 2 diabetic patients. However, because most studies reporting the relationships between endothelial function, intima-media thickness (IMT), and hyperglycemia have compared diabetic patients with healthy controls, we report their relationship with glycemia as a continuum. METHODS AND RESULTS: Brachial artery endothelial function (flow-mediated dilatation [FMD]) and carotid IMT were measured noninvasively by high-resolution ultrasound B-mode imaging in 228 apparently healthy Chinese subjects recruited from Hong Kong and Macau. FMD and IMT were significantly associated with increasing levels of glycemia, particularly in the "high normal" glycemic range, with IMT increasing and endothelium-independent dilatation decreasing linearly across the glucose tertiles, and endothelium-dependent dilatation significantly lower in the upper glucose tertile compared with the other 2 groups (P<0.01). Using multiple linear regression, fasting glucose level was identified as an independent predictor of each of these markers of vascular function (P<0.004). Additionally, other conventional cardiovascular risk factors, including obesity, blood pressure, and an adverse lipid profile, were also related to levels of glycemia (P<0.05), further contributing to impaired vascular function. CONCLUSIONS: Increasing levels of glycemia and the coexistence of other cardiovascular risk factors in apparently healthy subjects are adversely associated with arterial endothelial dysfunction and intima-media thickening. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/14739120/Deleterious_impact_of_"high_normal"_glucose_levels_and_other_metabolic_syndrome_components_on_arterial_endothelial_function_and_intima_media_thickness_in_apparently_healthy_Chinese_subjects:_the_CATHAY_study_ DB - PRIME DP - Unbound Medicine ER -