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Fasting plasma glucose and glycated haemoglobin in the screening of diabetes and impaired glucose tolerance.
Acta Diabetol. 2003 Dec; 40(4):181-6.AD

Abstract

The use of fasting plasma glucose (FPG) only has been proposed for the screening and diagnosis of diabetes, but its sensitivity has been reported to be unsatisfactory. The use of HbA1C, alone or combined with FPG, has been suggested for the screening of diabetes and impaired glucose tolerance (IGT). In a sample of 1215 adult subjects without previously known diabetes, we assessed the sensitivity and specificity of FPG and HbA1C in diagnosing diabetes and IGT, determined by oral glucose tolerance test (OGTT). All lean diabetic patients, and 85% of overweight and obese diabetic individuals, had FPG > or =7 mmol/l. FPG >6.1 mmol/l had a sensitivity of 98.8% and a specificity of 32.9%; HbA1C had a lower specificity and sensitivity for the screening of diabetes. A screening strategy for diabetes based on FPG, with OGTT in all overweight subjects with FPG >6.1 mmol/l, is suggested. Neither FPG nor HbA1C is effective in the screening of IGT; although combined FPG and HbA1C could be useful for case finding, screening for IGT with OGTT is advisable in all subjects at high risk.

Authors+Show Affiliations

Section of Metabolic Diseases and Diabetology, Endocrine Unit, Department of Clinical Pathophysiology, University of Florence Medical School, Viale Pieraccini 6, I-50134 Florence, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14740278

Citation

Mannucci, E, et al. "Fasting Plasma Glucose and Glycated Haemoglobin in the Screening of Diabetes and Impaired Glucose Tolerance." Acta Diabetologica, vol. 40, no. 4, 2003, pp. 181-6.
Mannucci E, Ognibene A, Sposato I, et al. Fasting plasma glucose and glycated haemoglobin in the screening of diabetes and impaired glucose tolerance. Acta Diabetol. 2003;40(4):181-6.
Mannucci, E., Ognibene, A., Sposato, I., Brogi, M., Gallori, G., Bardini, G., Cremasco, F., Messeri, G., & Rotella, C. M. (2003). Fasting plasma glucose and glycated haemoglobin in the screening of diabetes and impaired glucose tolerance. Acta Diabetologica, 40(4), 181-6.
Mannucci E, et al. Fasting Plasma Glucose and Glycated Haemoglobin in the Screening of Diabetes and Impaired Glucose Tolerance. Acta Diabetol. 2003;40(4):181-6. PubMed PMID: 14740278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fasting plasma glucose and glycated haemoglobin in the screening of diabetes and impaired glucose tolerance. AU - Mannucci,E, AU - Ognibene,A, AU - Sposato,I, AU - Brogi,M, AU - Gallori,G, AU - Bardini,G, AU - Cremasco,F, AU - Messeri,G, AU - Rotella,C M, PY - 2002/09/05/received PY - 2003/07/30/accepted PY - 2004/1/24/pubmed PY - 2004/3/6/medline PY - 2004/1/24/entrez SP - 181 EP - 6 JF - Acta diabetologica JO - Acta Diabetol VL - 40 IS - 4 N2 - The use of fasting plasma glucose (FPG) only has been proposed for the screening and diagnosis of diabetes, but its sensitivity has been reported to be unsatisfactory. The use of HbA1C, alone or combined with FPG, has been suggested for the screening of diabetes and impaired glucose tolerance (IGT). In a sample of 1215 adult subjects without previously known diabetes, we assessed the sensitivity and specificity of FPG and HbA1C in diagnosing diabetes and IGT, determined by oral glucose tolerance test (OGTT). All lean diabetic patients, and 85% of overweight and obese diabetic individuals, had FPG > or =7 mmol/l. FPG >6.1 mmol/l had a sensitivity of 98.8% and a specificity of 32.9%; HbA1C had a lower specificity and sensitivity for the screening of diabetes. A screening strategy for diabetes based on FPG, with OGTT in all overweight subjects with FPG >6.1 mmol/l, is suggested. Neither FPG nor HbA1C is effective in the screening of IGT; although combined FPG and HbA1C could be useful for case finding, screening for IGT with OGTT is advisable in all subjects at high risk. SN - 0940-5429 UR - https://www.unboundmedicine.com/medline/citation/14740278/Fasting_plasma_glucose_and_glycated_haemoglobin_in_the_screening_of_diabetes_and_impaired_glucose_tolerance_ L2 - https://dx.doi.org/10.1007/s00592-003-0109-8 DB - PRIME DP - Unbound Medicine ER -