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Effect of congestive heart failure on humoral and ex vivo cellular immune responses to influenza vaccination in older adults.
Vaccine 2004; 22(5-6):681-8V

Abstract

This study examined the effect of congestive heart failure (CHF) on immune responses to influenza vaccination (2000-2001 preparation) in three groups of older adults including healthy, Class II and Class III/IV CHF. Serum antibody titers measured by hemagglutination inhibition (HI), and interferon-gamma (IFN-gamma), interleukin-10 (IL-10) and granzyme B (GrzB) levels in ex vivo virus-activated mononuclear cell cultures showed significant responses from pre-vaccination to 4 and 12 weeks post-vaccination (P<0.01). There was a trend for lower GrzB and higher IFN-gamma and IL-10 levels in healthy versus CHF groups (P<0.06) for all viral strains at 4 weeks. HI titers did not differ between groups. In the regression model, Grz B levels were significantly predicted by the IFN-gamma:IL-10 ratio and performance on the 6 min Walk Test; age and CHF dropped out of the model. In conclusion, CHF in older adults predicts GrzB responses to influenza vaccination due to cytokine and physical ability differences.

Authors+Show Affiliations

Center for Immunotherapy of Cancer and Infectious Diseases, MC 1601, University of Connecticut, School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-1601, USA. jmcelhaney@uchc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14741160

Citation

McElhaney, Janet E., et al. "Effect of Congestive Heart Failure On Humoral and Ex Vivo Cellular Immune Responses to Influenza Vaccination in Older Adults." Vaccine, vol. 22, no. 5-6, 2004, pp. 681-8.
McElhaney JE, Herre JM, Lawson ML, et al. Effect of congestive heart failure on humoral and ex vivo cellular immune responses to influenza vaccination in older adults. Vaccine. 2004;22(5-6):681-8.
McElhaney, J. E., Herre, J. M., Lawson, M. L., Cole, S. K., Burke, B. L., & Hooton, J. W. (2004). Effect of congestive heart failure on humoral and ex vivo cellular immune responses to influenza vaccination in older adults. Vaccine, 22(5-6), pp. 681-8.
McElhaney JE, et al. Effect of Congestive Heart Failure On Humoral and Ex Vivo Cellular Immune Responses to Influenza Vaccination in Older Adults. Vaccine. 2004 Jan 26;22(5-6):681-8. PubMed PMID: 14741160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of congestive heart failure on humoral and ex vivo cellular immune responses to influenza vaccination in older adults. AU - McElhaney,Janet E, AU - Herre,John M, AU - Lawson,M Louise, AU - Cole,Sharon K, AU - Burke,Bonnie L, AU - Hooton,Jonathan W, PY - 2004/1/27/pubmed PY - 2004/4/14/medline PY - 2004/1/27/entrez SP - 681 EP - 8 JF - Vaccine JO - Vaccine VL - 22 IS - 5-6 N2 - This study examined the effect of congestive heart failure (CHF) on immune responses to influenza vaccination (2000-2001 preparation) in three groups of older adults including healthy, Class II and Class III/IV CHF. Serum antibody titers measured by hemagglutination inhibition (HI), and interferon-gamma (IFN-gamma), interleukin-10 (IL-10) and granzyme B (GrzB) levels in ex vivo virus-activated mononuclear cell cultures showed significant responses from pre-vaccination to 4 and 12 weeks post-vaccination (P<0.01). There was a trend for lower GrzB and higher IFN-gamma and IL-10 levels in healthy versus CHF groups (P<0.06) for all viral strains at 4 weeks. HI titers did not differ between groups. In the regression model, Grz B levels were significantly predicted by the IFN-gamma:IL-10 ratio and performance on the 6 min Walk Test; age and CHF dropped out of the model. In conclusion, CHF in older adults predicts GrzB responses to influenza vaccination due to cytokine and physical ability differences. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/14741160/Effect_of_congestive_heart_failure_on_humoral_and_ex_vivo_cellular_immune_responses_to_influenza_vaccination_in_older_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264410X03006455 DB - PRIME DP - Unbound Medicine ER -