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Effect of congestive heart failure on humoral and ex vivo cellular immune responses to influenza vaccination in older adults.

Abstract

This study examined the effect of congestive heart failure (CHF) on immune responses to influenza vaccination (2000-2001 preparation) in three groups of older adults including healthy, Class II and Class III/IV CHF. Serum antibody titers measured by hemagglutination inhibition (HI), and interferon-gamma (IFN-gamma), interleukin-10 (IL-10) and granzyme B (GrzB) levels in ex vivo virus-activated mononuclear cell cultures showed significant responses from pre-vaccination to 4 and 12 weeks post-vaccination (P<0.01). There was a trend for lower GrzB and higher IFN-gamma and IL-10 levels in healthy versus CHF groups (P<0.06) for all viral strains at 4 weeks. HI titers did not differ between groups. In the regression model, Grz B levels were significantly predicted by the IFN-gamma:IL-10 ratio and performance on the 6 min Walk Test; age and CHF dropped out of the model. In conclusion, CHF in older adults predicts GrzB responses to influenza vaccination due to cytokine and physical ability differences.

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  • Authors+Show Affiliations

    ,

    Center for Immunotherapy of Cancer and Infectious Diseases, MC 1601, University of Connecticut, School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-1601, USA. jmcelhaney@uchc.edu

    , , , ,

    Source

    Vaccine 22:5-6 2004 Jan 26 pg 681-8

    MeSH

    Aged
    Aged, 80 and over
    Antibodies, Viral
    Antibody Formation
    Exercise Test
    Female
    Granzymes
    Heart Failure
    Humans
    Immunity, Cellular
    Influenza Vaccines
    Influenza, Human
    Interferon-gamma
    Interleukin-10
    Male
    Middle Aged
    Regression Analysis
    Serine Endopeptidases
    T-Lymphocytes, Cytotoxic
    Vaccination

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    14741160

    Citation

    McElhaney, Janet E., et al. "Effect of Congestive Heart Failure On Humoral and Ex Vivo Cellular Immune Responses to Influenza Vaccination in Older Adults." Vaccine, vol. 22, no. 5-6, 2004, pp. 681-8.
    McElhaney JE, Herre JM, Lawson ML, et al. Effect of congestive heart failure on humoral and ex vivo cellular immune responses to influenza vaccination in older adults. Vaccine. 2004;22(5-6):681-8.
    McElhaney, J. E., Herre, J. M., Lawson, M. L., Cole, S. K., Burke, B. L., & Hooton, J. W. (2004). Effect of congestive heart failure on humoral and ex vivo cellular immune responses to influenza vaccination in older adults. Vaccine, 22(5-6), pp. 681-8.
    McElhaney JE, et al. Effect of Congestive Heart Failure On Humoral and Ex Vivo Cellular Immune Responses to Influenza Vaccination in Older Adults. Vaccine. 2004 Jan 26;22(5-6):681-8. PubMed PMID: 14741160.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of congestive heart failure on humoral and ex vivo cellular immune responses to influenza vaccination in older adults. AU - McElhaney,Janet E, AU - Herre,John M, AU - Lawson,M Louise, AU - Cole,Sharon K, AU - Burke,Bonnie L, AU - Hooton,Jonathan W, PY - 2004/1/27/pubmed PY - 2004/4/14/medline PY - 2004/1/27/entrez SP - 681 EP - 8 JF - Vaccine JO - Vaccine VL - 22 IS - 5-6 N2 - This study examined the effect of congestive heart failure (CHF) on immune responses to influenza vaccination (2000-2001 preparation) in three groups of older adults including healthy, Class II and Class III/IV CHF. Serum antibody titers measured by hemagglutination inhibition (HI), and interferon-gamma (IFN-gamma), interleukin-10 (IL-10) and granzyme B (GrzB) levels in ex vivo virus-activated mononuclear cell cultures showed significant responses from pre-vaccination to 4 and 12 weeks post-vaccination (P<0.01). There was a trend for lower GrzB and higher IFN-gamma and IL-10 levels in healthy versus CHF groups (P<0.06) for all viral strains at 4 weeks. HI titers did not differ between groups. In the regression model, Grz B levels were significantly predicted by the IFN-gamma:IL-10 ratio and performance on the 6 min Walk Test; age and CHF dropped out of the model. In conclusion, CHF in older adults predicts GrzB responses to influenza vaccination due to cytokine and physical ability differences. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/14741160/Effect_of_congestive_heart_failure_on_humoral_and_ex_vivo_cellular_immune_responses_to_influenza_vaccination_in_older_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264410X03006455 DB - PRIME DP - Unbound Medicine ER -