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Antipyretic efficacy and safety of ibuprofen and acetaminophen in children.
Ann Pharmacother. 2004 Jan; 38(1):146-50.AP

Abstract

OBJECTIVE

To evaluate the antipyretic effects and safety of ibuprofen compared with acetaminophen in febrile children.

DATA SOURCES

Searches of MEDLINE (1966-November 2003) and EMBASE (1988-November 2003) were conducted using the terms ibuprofen and acetaminophen. Bibliographies of selected articles were reviewed.

DATA SYNTHESIS

Ibuprofen was significantly more effective than acetaminophen in reducing fever after a single dose. Ibuprofen was found to be more effective after 6 hours, but not after a longer period of time. Studies with multiple doses have also failed to show that one drug is better than the other.

CONCLUSIONS

The efficacy and effectiveness of acetaminophen and ibuprofen in their recommended dosages are similar, with slightly more beneficial effects shown with ibuprofen.

Authors+Show Affiliations

Pediatric Emergency Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. ran.goldman@sickkids.caNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Review

Language

eng

PubMed ID

14742809

Citation

Goldman, Ran D., et al. "Antipyretic Efficacy and Safety of Ibuprofen and Acetaminophen in Children." The Annals of Pharmacotherapy, vol. 38, no. 1, 2004, pp. 146-50.
Goldman RD, Ko K, Linett LJ, et al. Antipyretic efficacy and safety of ibuprofen and acetaminophen in children. Ann Pharmacother. 2004;38(1):146-50.
Goldman, R. D., Ko, K., Linett, L. J., & Scolnik, D. (2004). Antipyretic efficacy and safety of ibuprofen and acetaminophen in children. The Annals of Pharmacotherapy, 38(1), 146-50.
Goldman RD, et al. Antipyretic Efficacy and Safety of Ibuprofen and Acetaminophen in Children. Ann Pharmacother. 2004;38(1):146-50. PubMed PMID: 14742809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antipyretic efficacy and safety of ibuprofen and acetaminophen in children. AU - Goldman,Ran D, AU - Ko,Karen, AU - Linett,Lauren J, AU - Scolnik,Dennis, PY - 2004/1/27/pubmed PY - 2004/3/17/medline PY - 2004/1/27/entrez SP - 146 EP - 50 JF - The Annals of pharmacotherapy JO - Ann Pharmacother VL - 38 IS - 1 N2 - OBJECTIVE: To evaluate the antipyretic effects and safety of ibuprofen compared with acetaminophen in febrile children. DATA SOURCES: Searches of MEDLINE (1966-November 2003) and EMBASE (1988-November 2003) were conducted using the terms ibuprofen and acetaminophen. Bibliographies of selected articles were reviewed. DATA SYNTHESIS: Ibuprofen was significantly more effective than acetaminophen in reducing fever after a single dose. Ibuprofen was found to be more effective after 6 hours, but not after a longer period of time. Studies with multiple doses have also failed to show that one drug is better than the other. CONCLUSIONS: The efficacy and effectiveness of acetaminophen and ibuprofen in their recommended dosages are similar, with slightly more beneficial effects shown with ibuprofen. SN - 1060-0280 UR - https://www.unboundmedicine.com/medline/citation/14742809/Antipyretic_efficacy_and_safety_of_ibuprofen_and_acetaminophen_in_children_ L2 - https://journals.sagepub.com/doi/10.1345/aph.1C391?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -