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Bone and gastric bypass surgery: effects of dietary calcium and vitamin D.
Obes Res. 2004 Jan; 12(1):40-7.OR

Abstract

OBJECTIVE

To examine bone mass and metabolism in women who had previously undergone Roux-en-Y gastric bypass (RYGB) and determine the effect of supplementation with calcium (Ca) and vitamin D.

RESEARCH METHODS AND PROCEDURES

Bone mineral density and bone mineral content (BMC) were examined in 44 RYGB women (> or = 3 years post-surgery; 31% weight loss; BMI, 34 kg/m(2)) and compared with age- and weight-matched control (CNT) women (n = 65). In a separate analysis, RYGB women who presented with low bone mass (n = 13) were supplemented to a total 1.2 g Ca/d and 8 microg vitamin D/d over 6 months and compared with an unsupplemented CNT group (n = 13). Bone mass and turnover and serum parathyroid hormone (PTH) and 25-hydroxyvitamin D were measured.

RESULTS

Bone mass did not differ between premenopausal RYGB and CNT women (42 +/- 5 years), whereas postmenopausal RYGB women (55 +/- 7 years) had higher bone mineral density and BMC at the lumbar spine and lower BMC at the femoral neck. Before and after dietary supplementation, bone mass was similar, and serum PTH and markers of bone resorption were higher (p < 0.001) in RYGB compared with CNT women and did not change significantly after supplementation.

DISCUSSION

Postmenopausal RYGB women show evidence of secondary hyperparathyroidism, elevated bone resorption, and patterns of bone loss (reduced femoral neck and higher lumbar spine) similar to other subjects with hyperparathyroidism. Although a modest increase in Ca or vitamin D does not suppress PTH or bone resorption, it is possible that greater dietary supplementation may be beneficial.

Authors+Show Affiliations

Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

14742841

Citation

Goode, Lisa R., et al. "Bone and Gastric Bypass Surgery: Effects of Dietary Calcium and Vitamin D." Obesity Research, vol. 12, no. 1, 2004, pp. 40-7.
Goode LR, Brolin RE, Chowdhury HA, et al. Bone and gastric bypass surgery: effects of dietary calcium and vitamin D. Obes Res. 2004;12(1):40-7.
Goode, L. R., Brolin, R. E., Chowdhury, H. A., & Shapses, S. A. (2004). Bone and gastric bypass surgery: effects of dietary calcium and vitamin D. Obesity Research, 12(1), 40-7.
Goode LR, et al. Bone and Gastric Bypass Surgery: Effects of Dietary Calcium and Vitamin D. Obes Res. 2004;12(1):40-7. PubMed PMID: 14742841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone and gastric bypass surgery: effects of dietary calcium and vitamin D. AU - Goode,Lisa R, AU - Brolin,Robert E, AU - Chowdhury,Hasina A, AU - Shapses,Sue A, PY - 2004/1/27/pubmed PY - 2004/5/15/medline PY - 2004/1/27/entrez SP - 40 EP - 7 JF - Obesity research JO - Obes Res VL - 12 IS - 1 N2 - OBJECTIVE: To examine bone mass and metabolism in women who had previously undergone Roux-en-Y gastric bypass (RYGB) and determine the effect of supplementation with calcium (Ca) and vitamin D. RESEARCH METHODS AND PROCEDURES: Bone mineral density and bone mineral content (BMC) were examined in 44 RYGB women (> or = 3 years post-surgery; 31% weight loss; BMI, 34 kg/m(2)) and compared with age- and weight-matched control (CNT) women (n = 65). In a separate analysis, RYGB women who presented with low bone mass (n = 13) were supplemented to a total 1.2 g Ca/d and 8 microg vitamin D/d over 6 months and compared with an unsupplemented CNT group (n = 13). Bone mass and turnover and serum parathyroid hormone (PTH) and 25-hydroxyvitamin D were measured. RESULTS: Bone mass did not differ between premenopausal RYGB and CNT women (42 +/- 5 years), whereas postmenopausal RYGB women (55 +/- 7 years) had higher bone mineral density and BMC at the lumbar spine and lower BMC at the femoral neck. Before and after dietary supplementation, bone mass was similar, and serum PTH and markers of bone resorption were higher (p < 0.001) in RYGB compared with CNT women and did not change significantly after supplementation. DISCUSSION: Postmenopausal RYGB women show evidence of secondary hyperparathyroidism, elevated bone resorption, and patterns of bone loss (reduced femoral neck and higher lumbar spine) similar to other subjects with hyperparathyroidism. Although a modest increase in Ca or vitamin D does not suppress PTH or bone resorption, it is possible that greater dietary supplementation may be beneficial. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/14742841/Bone_and_gastric_bypass_surgery:_effects_of_dietary_calcium_and_vitamin_D_ DB - PRIME DP - Unbound Medicine ER -