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Selenium concentrations and glutathione peroxidase activities in blood of patients before and after allogenic kidney transplantation.
Biol Trace Elem Res. 2004 Jan; 97(1):1-13.BT

Abstract

In animals and humans, the highest level of selenium (Se) occurs in the kidney. This organ is also the major site of the synthesis of the selenoenzyme glutathione peroxidase (GSH-Px). Decreased Se levels and GSH-Px activities in blood are common symptoms in the advanced stage of chronic renal failure (CRF). Blood samples for Se levels and GSH-Px activities measurements from patients were collected just before transplantation and 3, 7, 14, 30, and 90 d posttransplant. The Se levels in whole blood and plasma of patients before transplantation (79.5 and 64.5 ng/mL, respectively) were lower by 23% and 21%, respectively, as compared with controls (p < 0.0001), and 7 d after operation, it further decreased in both components (p < 0.01). Fourteen days after surgery, the levels reached the initial values and increased slowly in the later period. Red blood cell GSHPx activity in patients in the entire period of the study did not differ from the control group. Plasma GSH-Px of patients before the surgery was extremely low (76 U/L) as compared with controls (243 U/L; p < 0.0001) but increased rapidly to 115 U/L after 3 d, to 164 U/L after 14 d, and to 208 U/L after 3 mo posttransplant. In CRF patients, after kidney transplantation, plasma GSH-Px activity increased rapidly, approaching, after 3 mo, the values that were close to the normal levels. A negative correlation between creatinine level and plasma GSH-Px activity is observed in patients after kidney transplantation. Monitoring of plasma GSH-Px activity may be a useful additional marker of the transplanted kidney function.

Authors+Show Affiliations

Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

14742896

Citation

Zachara, Bronisław A., et al. "Selenium Concentrations and Glutathione Peroxidase Activities in Blood of Patients Before and After Allogenic Kidney Transplantation." Biological Trace Element Research, vol. 97, no. 1, 2004, pp. 1-13.
Zachara BA, Włodarczyk Z, Masztalerz M, et al. Selenium concentrations and glutathione peroxidase activities in blood of patients before and after allogenic kidney transplantation. Biol Trace Elem Res. 2004;97(1):1-13.
Zachara, B. A., Włodarczyk, Z., Masztalerz, M., Adamowicz, A., Gromadzinska, J., & Wasowicz, W. (2004). Selenium concentrations and glutathione peroxidase activities in blood of patients before and after allogenic kidney transplantation. Biological Trace Element Research, 97(1), 1-13.
Zachara BA, et al. Selenium Concentrations and Glutathione Peroxidase Activities in Blood of Patients Before and After Allogenic Kidney Transplantation. Biol Trace Elem Res. 2004;97(1):1-13. PubMed PMID: 14742896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium concentrations and glutathione peroxidase activities in blood of patients before and after allogenic kidney transplantation. AU - Zachara,Bronisław A, AU - Włodarczyk,Zbigniew, AU - Masztalerz,Marek, AU - Adamowicz,Andrzej, AU - Gromadzinska,Jolanta, AU - Wasowicz,Wojciech, PY - 2003/03/17/received PY - 2003/04/03/revised PY - 2003/04/03/accepted PY - 2004/1/27/pubmed PY - 2004/9/8/medline PY - 2004/1/27/entrez SP - 1 EP - 13 JF - Biological trace element research JO - Biol Trace Elem Res VL - 97 IS - 1 N2 - In animals and humans, the highest level of selenium (Se) occurs in the kidney. This organ is also the major site of the synthesis of the selenoenzyme glutathione peroxidase (GSH-Px). Decreased Se levels and GSH-Px activities in blood are common symptoms in the advanced stage of chronic renal failure (CRF). Blood samples for Se levels and GSH-Px activities measurements from patients were collected just before transplantation and 3, 7, 14, 30, and 90 d posttransplant. The Se levels in whole blood and plasma of patients before transplantation (79.5 and 64.5 ng/mL, respectively) were lower by 23% and 21%, respectively, as compared with controls (p < 0.0001), and 7 d after operation, it further decreased in both components (p < 0.01). Fourteen days after surgery, the levels reached the initial values and increased slowly in the later period. Red blood cell GSHPx activity in patients in the entire period of the study did not differ from the control group. Plasma GSH-Px of patients before the surgery was extremely low (76 U/L) as compared with controls (243 U/L; p < 0.0001) but increased rapidly to 115 U/L after 3 d, to 164 U/L after 14 d, and to 208 U/L after 3 mo posttransplant. In CRF patients, after kidney transplantation, plasma GSH-Px activity increased rapidly, approaching, after 3 mo, the values that were close to the normal levels. A negative correlation between creatinine level and plasma GSH-Px activity is observed in patients after kidney transplantation. Monitoring of plasma GSH-Px activity may be a useful additional marker of the transplanted kidney function. SN - 0163-4984 UR - https://www.unboundmedicine.com/medline/citation/14742896/Selenium_concentrations_and_glutathione_peroxidase_activities_in_blood_of_patients_before_and_after_allogenic_kidney_transplantation_ L2 - https://dx.doi.org/10.1385/BTER:97:1:1 DB - PRIME DP - Unbound Medicine ER -