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Quality of life in early Parkinson's disease: impact of dyskinesias and motor fluctuations.
Mov Disord. 2004 Jan; 19(1):22-8.MD

Abstract

The impact of dyskinesias and motor fluctuations on quality of life (QOL) at various stages in the course of Parkinson's disease (PD) is not well understood. In 301 subjects with early PD enrolled in a clinical trial (CALM-PD), we quantified the impact of motor complications on QOL and investigated how this changes over time. We also compared QOL related to demographic and treatment characteristics. The presence of dyskinesias was associated with visual analogue scale (VAS) scores 3.0 of 100 points higher (better) than those without dyskinesias in years 1 to 2, even when adjusting for Unified Parkinson's Disease Rating Scale (UPDRS) motor scores. The positive association between dyskinesias and QOL scores was more marked in older patients. In years 3 to 4, dyskinesias no longer had a significant relationship with QOL. Younger subjects had higher VAS scores. Gender, motor fluctuations, and treatment regimen had no significant association with QOL, although a trend was found toward a small negative effect of motor fluctuations on QOL. We conclude that motor complications that occur within the first 4 years of treatment of PD do not have a significant negative effect on quality of life as measured by a visual analogue scale for most patients.

Authors+Show Affiliations

Division of Neurology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14743356

Citation

Marras, Connie, et al. "Quality of Life in Early Parkinson's Disease: Impact of Dyskinesias and Motor Fluctuations." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 19, no. 1, 2004, pp. 22-8.
Marras C, Lang A, Krahn M, et al. Quality of life in early Parkinson's disease: impact of dyskinesias and motor fluctuations. Mov Disord. 2004;19(1):22-8.
Marras, C., Lang, A., Krahn, M., Tomlinson, G., & Naglie, G. (2004). Quality of life in early Parkinson's disease: impact of dyskinesias and motor fluctuations. Movement Disorders : Official Journal of the Movement Disorder Society, 19(1), 22-8.
Marras C, et al. Quality of Life in Early Parkinson's Disease: Impact of Dyskinesias and Motor Fluctuations. Mov Disord. 2004;19(1):22-8. PubMed PMID: 14743356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quality of life in early Parkinson's disease: impact of dyskinesias and motor fluctuations. AU - Marras,Connie, AU - Lang,Anthony, AU - Krahn,Murray, AU - Tomlinson,George, AU - Naglie,Gary, AU - ,, PY - 2004/1/27/pubmed PY - 2004/9/1/medline PY - 2004/1/27/entrez SP - 22 EP - 8 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 19 IS - 1 N2 - The impact of dyskinesias and motor fluctuations on quality of life (QOL) at various stages in the course of Parkinson's disease (PD) is not well understood. In 301 subjects with early PD enrolled in a clinical trial (CALM-PD), we quantified the impact of motor complications on QOL and investigated how this changes over time. We also compared QOL related to demographic and treatment characteristics. The presence of dyskinesias was associated with visual analogue scale (VAS) scores 3.0 of 100 points higher (better) than those without dyskinesias in years 1 to 2, even when adjusting for Unified Parkinson's Disease Rating Scale (UPDRS) motor scores. The positive association between dyskinesias and QOL scores was more marked in older patients. In years 3 to 4, dyskinesias no longer had a significant relationship with QOL. Younger subjects had higher VAS scores. Gender, motor fluctuations, and treatment regimen had no significant association with QOL, although a trend was found toward a small negative effect of motor fluctuations on QOL. We conclude that motor complications that occur within the first 4 years of treatment of PD do not have a significant negative effect on quality of life as measured by a visual analogue scale for most patients. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/14743356/Quality_of_life_in_early_Parkinson's_disease:_impact_of_dyskinesias_and_motor_fluctuations_ L2 - https://doi.org/10.1002/mds.10642 DB - PRIME DP - Unbound Medicine ER -