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Quetiapine improves psychotic symptoms and cognition in Parkinson's disease.
Mov Disord. 2004 Jan; 19(1):29-35.MD

Abstract

Twenty-nine elderly patients who failed treatment with clozapine, risperidone, or olanzapine entered this 24-week, single-center, open-label trial to assess the efficacy of quetiapine (12.5-400 mg/day) for psychosis in patients with Parkinson's disease (PD). Psychiatric, motor, and cognitive assessments were administered at baseline and at periodic intervals for 24 weeks. These included the Brief Psychiatric Rating Scale (BPRS), Neuropsychiatric Inventory (NPI), Unified Parkinson's Disease Rating Scale (UPDRS) and tests of intellectual functioning, attention, and memory. Repeated measures statistical analysis was used to assess change from baseline. The results revealed significant improvements in the 24-week BPRS total score and NPI psychosis subscale scores, with no decline in UPDRS total or motor subscale scores. There was also significant improvement in recall scores on cognitive measures. These results indicate that quetiapine may treat psychotic symptoms and improve cognition without worsening motor function in patients with PD, suggesting that quetiapine is an effective and well-tolerated antipsychotic in this population.

Authors+Show Affiliations

Neurology Department, Emory University, Atlanta, Georgia 30329, USA. jjuncos@emory.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14743357

Citation

Juncos, Jorge L., et al. "Quetiapine Improves Psychotic Symptoms and Cognition in Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 19, no. 1, 2004, pp. 29-35.
Juncos JL, Roberts VJ, Evatt ML, et al. Quetiapine improves psychotic symptoms and cognition in Parkinson's disease. Mov Disord. 2004;19(1):29-35.
Juncos, J. L., Roberts, V. J., Evatt, M. L., Jewart, R. D., Wood, C. D., Potter, L. S., Jou, H. C., & Yeung, P. P. (2004). Quetiapine improves psychotic symptoms and cognition in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 19(1), 29-35.
Juncos JL, et al. Quetiapine Improves Psychotic Symptoms and Cognition in Parkinson's Disease. Mov Disord. 2004;19(1):29-35. PubMed PMID: 14743357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quetiapine improves psychotic symptoms and cognition in Parkinson's disease. AU - Juncos,Jorge L, AU - Roberts,Vicki J, AU - Evatt,Marian L, AU - Jewart,Rita D, AU - Wood,Colleen D, AU - Potter,Larry S, AU - Jou,Hann-Chang, AU - Yeung,Paul P, PY - 2004/1/27/pubmed PY - 2004/9/1/medline PY - 2004/1/27/entrez SP - 29 EP - 35 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 19 IS - 1 N2 - Twenty-nine elderly patients who failed treatment with clozapine, risperidone, or olanzapine entered this 24-week, single-center, open-label trial to assess the efficacy of quetiapine (12.5-400 mg/day) for psychosis in patients with Parkinson's disease (PD). Psychiatric, motor, and cognitive assessments were administered at baseline and at periodic intervals for 24 weeks. These included the Brief Psychiatric Rating Scale (BPRS), Neuropsychiatric Inventory (NPI), Unified Parkinson's Disease Rating Scale (UPDRS) and tests of intellectual functioning, attention, and memory. Repeated measures statistical analysis was used to assess change from baseline. The results revealed significant improvements in the 24-week BPRS total score and NPI psychosis subscale scores, with no decline in UPDRS total or motor subscale scores. There was also significant improvement in recall scores on cognitive measures. These results indicate that quetiapine may treat psychotic symptoms and improve cognition without worsening motor function in patients with PD, suggesting that quetiapine is an effective and well-tolerated antipsychotic in this population. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/14743357/Quetiapine_improves_psychotic_symptoms_and_cognition_in_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.10620 DB - PRIME DP - Unbound Medicine ER -