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Comparison of dementia with Lewy bodies to Alzheimer's disease and Parkinson's disease with dementia.
Mov Disord. 2004 Jan; 19(1):60-7.MD

Abstract

We compared the clinical and neuropsychological pattern of dementia with Lewy bodies (DLB) to Alzheimer's disease (AD) and Parkinson's disease with dementia (PD-d). Sixteen patients clinically diagnosed with DLB were compared with two groups of patients with PD-d (n = 15) and AD (n = 16) matched for level of dementia. Isolated cognitive impairment was the most common form of presentation in AD (93.8%) and DLB (31.3%) groups, while parkinsonism was in 100% of PD-d subjects. Psychoses associated with cognitive impairment at the beginning of the disease were more frequent in DLB patients (31.3%) than in AD (6.3%) and PD-d (0%) groups. There were no significant differences in Unified Parkinson Disease Rating Scale motor-subscale scores between DLB and PD-d patients. DLB and PD-d patients performed significantly worse on attentional functions and better on memory tests than AD. DLB patients also showed lower scores than AD subjects on visual memory, visuoperceptive, and visuoconstructive tests. No significant differences were found between PD-d group and DLB subjects on any neuropsychological test. We were unable to find any differences in cognitive tasks between PD-d and DLB subjects. Clinical features and neuropsychological deficiencies of DLB (attentional, visuoperceptive, and visuoconstructive deficits) and PD (attentional deficits) compared to AD (amnesic syndrome) can contribute to accurate identification of these entities and to the understanding of the neuropathological and neurochemical substrate underlying these diseases.

Authors+Show Affiliations

Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, USA. enoe@comv.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14743362

Citation

Noe, Enrique, et al. "Comparison of Dementia With Lewy Bodies to Alzheimer's Disease and Parkinson's Disease With Dementia." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 19, no. 1, 2004, pp. 60-7.
Noe E, Marder K, Bell KL, et al. Comparison of dementia with Lewy bodies to Alzheimer's disease and Parkinson's disease with dementia. Mov Disord. 2004;19(1):60-7.
Noe, E., Marder, K., Bell, K. L., Jacobs, D. M., Manly, J. J., & Stern, Y. (2004). Comparison of dementia with Lewy bodies to Alzheimer's disease and Parkinson's disease with dementia. Movement Disorders : Official Journal of the Movement Disorder Society, 19(1), 60-7.
Noe E, et al. Comparison of Dementia With Lewy Bodies to Alzheimer's Disease and Parkinson's Disease With Dementia. Mov Disord. 2004;19(1):60-7. PubMed PMID: 14743362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of dementia with Lewy bodies to Alzheimer's disease and Parkinson's disease with dementia. AU - Noe,Enrique, AU - Marder,Karen, AU - Bell,Karen L, AU - Jacobs,Diane M, AU - Manly,Jennifer J, AU - Stern,Yaakov, PY - 2004/1/27/pubmed PY - 2004/9/1/medline PY - 2004/1/27/entrez SP - 60 EP - 7 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 19 IS - 1 N2 - We compared the clinical and neuropsychological pattern of dementia with Lewy bodies (DLB) to Alzheimer's disease (AD) and Parkinson's disease with dementia (PD-d). Sixteen patients clinically diagnosed with DLB were compared with two groups of patients with PD-d (n = 15) and AD (n = 16) matched for level of dementia. Isolated cognitive impairment was the most common form of presentation in AD (93.8%) and DLB (31.3%) groups, while parkinsonism was in 100% of PD-d subjects. Psychoses associated with cognitive impairment at the beginning of the disease were more frequent in DLB patients (31.3%) than in AD (6.3%) and PD-d (0%) groups. There were no significant differences in Unified Parkinson Disease Rating Scale motor-subscale scores between DLB and PD-d patients. DLB and PD-d patients performed significantly worse on attentional functions and better on memory tests than AD. DLB patients also showed lower scores than AD subjects on visual memory, visuoperceptive, and visuoconstructive tests. No significant differences were found between PD-d group and DLB subjects on any neuropsychological test. We were unable to find any differences in cognitive tasks between PD-d and DLB subjects. Clinical features and neuropsychological deficiencies of DLB (attentional, visuoperceptive, and visuoconstructive deficits) and PD (attentional deficits) compared to AD (amnesic syndrome) can contribute to accurate identification of these entities and to the understanding of the neuropathological and neurochemical substrate underlying these diseases. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/14743362/Comparison_of_dementia_with_Lewy_bodies_to_Alzheimer's_disease_and_Parkinson's_disease_with_dementia_ L2 - https://doi.org/10.1002/mds.10633 DB - PRIME DP - Unbound Medicine ER -