Tags

Type your tag names separated by a space and hit enter

Estrogenic effects of Pueraria mirifica on the menstrual cycle and hormone-related ovarian functions in cyclic female cynomolgus monkeys.

Abstract

This study investigated the estrogenic effect of Pueraria mirifica (P. mirifica) on menstrual cycle length and hormone-related ovarian function. Nine normal cyclic monkeys (Macaca fascicularis) were separated into 3 groups; each group was force fed with a single dose of 10, 100, and 1,000 mg of P. mirifica. The experimental schedule was separated into the pre-treatment and post-treatment periods. Blood samples were collected on days 3, 9 - 14, 19, 24, 29, and every 10 days until the next menstruation for one and two menstrual cycles during two consecutive periods and assayed for serum levels of gonadotropins and ovarian hormones. The result showed a significant increase in lengths of the follicular phase and total menstrual cycle in monkeys treated with 1,000 mg of P. mirifica, but no change in menstrual cycle length in monkeys treated with 10 and 100 mg of P. mirifica. Serum levels of follicle stimulating hormone, luteinizing hormone, estradiol, progesterone, or immunoreactive-inhibin did not change during the first and second menstrual cycles of the post-treatment period for all monkey groups. Our findings demonstrate that although changes in hormonal levels could not be observed in this study, a single dose of 1,000 mg of P. mirifica can disturb ovarian function and menstrual cycle in monkeys.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Biological Science Ph.D. Program, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.

    , ,

    Source

    MeSH

    Animals
    Dose-Response Relationship, Drug
    Estradiol
    Female
    Follicle Stimulating Hormone
    Gonadotropins
    Luteinizing Hormone
    Macaca fascicularis
    Menstrual Cycle
    Ovary
    Phytoestrogens
    Progesterone
    Pueraria
    Time Factors

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14745118

    Citation

    Trisomboon, Hataitip, et al. "Estrogenic Effects of Pueraria Mirifica On the Menstrual Cycle and Hormone-related Ovarian Functions in Cyclic Female Cynomolgus Monkeys." Journal of Pharmacological Sciences, vol. 94, no. 1, 2004, pp. 51-9.
    Trisomboon H, Malaivijitnond S, Watanabe G, et al. Estrogenic effects of Pueraria mirifica on the menstrual cycle and hormone-related ovarian functions in cyclic female cynomolgus monkeys. J Pharmacol Sci. 2004;94(1):51-9.
    Trisomboon, H., Malaivijitnond, S., Watanabe, G., & Taya, K. (2004). Estrogenic effects of Pueraria mirifica on the menstrual cycle and hormone-related ovarian functions in cyclic female cynomolgus monkeys. Journal of Pharmacological Sciences, 94(1), pp. 51-9.
    Trisomboon H, et al. Estrogenic Effects of Pueraria Mirifica On the Menstrual Cycle and Hormone-related Ovarian Functions in Cyclic Female Cynomolgus Monkeys. J Pharmacol Sci. 2004;94(1):51-9. PubMed PMID: 14745118.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Estrogenic effects of Pueraria mirifica on the menstrual cycle and hormone-related ovarian functions in cyclic female cynomolgus monkeys. AU - Trisomboon,Hataitip, AU - Malaivijitnond,Suchinda, AU - Watanabe,Gen, AU - Taya,Kazuyoshi, PY - 2004/1/28/pubmed PY - 2004/12/29/medline PY - 2004/1/28/entrez SP - 51 EP - 9 JF - Journal of pharmacological sciences JO - J. Pharmacol. Sci. VL - 94 IS - 1 N2 - This study investigated the estrogenic effect of Pueraria mirifica (P. mirifica) on menstrual cycle length and hormone-related ovarian function. Nine normal cyclic monkeys (Macaca fascicularis) were separated into 3 groups; each group was force fed with a single dose of 10, 100, and 1,000 mg of P. mirifica. The experimental schedule was separated into the pre-treatment and post-treatment periods. Blood samples were collected on days 3, 9 - 14, 19, 24, 29, and every 10 days until the next menstruation for one and two menstrual cycles during two consecutive periods and assayed for serum levels of gonadotropins and ovarian hormones. The result showed a significant increase in lengths of the follicular phase and total menstrual cycle in monkeys treated with 1,000 mg of P. mirifica, but no change in menstrual cycle length in monkeys treated with 10 and 100 mg of P. mirifica. Serum levels of follicle stimulating hormone, luteinizing hormone, estradiol, progesterone, or immunoreactive-inhibin did not change during the first and second menstrual cycles of the post-treatment period for all monkey groups. Our findings demonstrate that although changes in hormonal levels could not be observed in this study, a single dose of 1,000 mg of P. mirifica can disturb ovarian function and menstrual cycle in monkeys. SN - 1347-8613 UR - https://www.unboundmedicine.com/medline/citation/14745118/Estrogenic_effects_of_Pueraria_mirifica_on_the_menstrual_cycle_and_hormone_related_ovarian_functions_in_cyclic_female_cynomolgus_monkeys_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/jphs/94.51?from=PubMed DB - PRIME DP - Unbound Medicine ER -