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Effects of pregnancy after treatment for breast carcinoma on survival and risk of recurrence.
Cancer. 2004 Feb 01; 100(3):465-9.C

Abstract

BACKGROUND

The goal of the current study was to assess the effect of pregnancy on the subsequent risk of recurrence after treatment for breast carcinoma, adjusting for established prognostic factors.

METHODS

Between 1974 and 1998, 383 patients age < or =35 years were treated for breast carcinoma with adjuvant chemotherapy at The University of Texas M. D. Anderson Cancer Center (Houston, TX). The median follow-up period was 13 years. Of these, 13 patients were excluded from analysis, as no history was available regarding pregnancy; 240 (65%) were >30 years old; 47 (13%) had at least 1 pregnancy after therapy; 32 had full-term pregnancies; 10 had spontaneous or elective abortions; 4 had miscarriages; and 1 had a premature delivery. Estrogen receptor (ER) status, lymph node involvement, and disease stage were evaluated as potential risk factors for recurrence. Information on ER status was unavailable for 123 (33%) patients.

RESULTS

Patients who experienced a pregnancy tended to have earlier-stage disease (Stage I/II: 80% vs. 73%), fewer positive lymph nodes (<4: 87% vs. 52%), more ER negativity (68% vs. 58%), and younger age (<30 years: 57% vs. 32%) than patients who did not. The incidence of disease recurrence was 23% for women who experienced a pregnancy and 54% for women who did not. The hazard ratio (using the multivariate Cox proportional hazards model) for disease recurrence in patients with posttreatment pregnancy was 0.71 (P=0.4).

CONCLUSIONS

In the current study population, pregnancy was not associated with an increased risk of disease recurrence or poorer survival in patients previously treated for breast carcinoma.

Authors+Show Affiliations

Blakely LJ
Division of Cancer Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA.
Buzdar AU
No affiliation info available
Lozada JA
No affiliation info available
Shullaih SA
No affiliation info available
Hoy E
No affiliation info available
Smith TL
No affiliation info available
Hortobagyi GN
No affiliation info available

MeSH

AdultAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsCarcinomaCombined Modality TherapyConfidence IntervalsFemaleHumansIncidenceMastectomy, SegmentalNeoplasm Recurrence, LocalPregnancyPregnancy Complications, NeoplasticPregnancy OutcomePregnancy, High-RiskProbabilityPrognosisProportional Hazards ModelsReference ValuesRetrospective StudiesRisk FactorsSurvival Analysis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14745861

Citation

Blakely, L Johnetta, et al. "Effects of Pregnancy After Treatment for Breast Carcinoma On Survival and Risk of Recurrence." Cancer, vol. 100, no. 3, 2004, pp. 465-9.
Blakely LJ, Buzdar AU, Lozada JA, et al. Effects of pregnancy after treatment for breast carcinoma on survival and risk of recurrence. Cancer. 2004;100(3):465-9.
Blakely, L. J., Buzdar, A. U., Lozada, J. A., Shullaih, S. A., Hoy, E., Smith, T. L., & Hortobagyi, G. N. (2004). Effects of pregnancy after treatment for breast carcinoma on survival and risk of recurrence. Cancer, 100(3), 465-9.
Blakely LJ, et al. Effects of Pregnancy After Treatment for Breast Carcinoma On Survival and Risk of Recurrence. Cancer. 2004 Feb 1;100(3):465-9. PubMed PMID: 14745861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of pregnancy after treatment for breast carcinoma on survival and risk of recurrence. AU - Blakely,L Johnetta, AU - Buzdar,Aman U, AU - Lozada,Jose A, AU - Shullaih,Samer A, AU - Hoy,Emma, AU - Smith,Terry L, AU - Hortobagyi,Gabriel N, PY - 2004/1/28/pubmed PY - 2004/2/20/medline PY - 2004/1/28/entrez SP - 465 EP - 9 JF - Cancer JO - Cancer VL - 100 IS - 3 N2 - BACKGROUND: The goal of the current study was to assess the effect of pregnancy on the subsequent risk of recurrence after treatment for breast carcinoma, adjusting for established prognostic factors. METHODS: Between 1974 and 1998, 383 patients age < or =35 years were treated for breast carcinoma with adjuvant chemotherapy at The University of Texas M. D. Anderson Cancer Center (Houston, TX). The median follow-up period was 13 years. Of these, 13 patients were excluded from analysis, as no history was available regarding pregnancy; 240 (65%) were >30 years old; 47 (13%) had at least 1 pregnancy after therapy; 32 had full-term pregnancies; 10 had spontaneous or elective abortions; 4 had miscarriages; and 1 had a premature delivery. Estrogen receptor (ER) status, lymph node involvement, and disease stage were evaluated as potential risk factors for recurrence. Information on ER status was unavailable for 123 (33%) patients. RESULTS: Patients who experienced a pregnancy tended to have earlier-stage disease (Stage I/II: 80% vs. 73%), fewer positive lymph nodes (<4: 87% vs. 52%), more ER negativity (68% vs. 58%), and younger age (<30 years: 57% vs. 32%) than patients who did not. The incidence of disease recurrence was 23% for women who experienced a pregnancy and 54% for women who did not. The hazard ratio (using the multivariate Cox proportional hazards model) for disease recurrence in patients with posttreatment pregnancy was 0.71 (P=0.4). CONCLUSIONS: In the current study population, pregnancy was not associated with an increased risk of disease recurrence or poorer survival in patients previously treated for breast carcinoma. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/14745861/Effects_of_pregnancy_after_treatment_for_breast_carcinoma_on_survival_and_risk_of_recurrence_ DB - PRIME DP - Unbound Medicine ER -