Tags

Type your tag names separated by a space and hit enter

Exposure to the sun and sunbeds and the risk of cutaneous melanoma in the UK: a case-control study.

Abstract

Migration, latitude and case-control studies have clearly established a link between melanoma and sun exposure. This case-control study of melanoma was set up to examine the role of sun exposure and sunbeds in the pathogenesis of melanoma in the United Kingdom (UK), a country with low levels of ultraviolet radiation. The study included 413 cases and 416 controls. More than 10 severe sunburns compared with less than 10 sunburns was associated with an Odds Ratio (OR) of 1.98 (95% Confidence Interval (CI) 1.02-3.86) (P=0.04) when adjusted for age, gender and skin type. Sunburns before the age of 15 years were not associated with melanoma once adjustments for age, gender and skin were made. 31% of women and 16% of the men had used sunbeds. Sunbed users were younger than non-users (40 years versus 51 years, P<0.0001). Ever use of sunbeds gave an adjusted OR of 1.19 (95% CI 0.84-1.68) (P=0.33). The risk of melanoma did not increase with increasing hours or years of sunbed exposure. The risk associated with sunbed use was only significant for young individuals with fair skin for whom there was a significant OR of 2.66 (95% CI 1.66-6.09) (P=0.02) after adjustment for the sun exposure variables. Outdoor occupation and residence in hot countries were not associated with an increased risk of melanoma. The only significant associations in this study were with 10 or more sunburns and the use of a sunbed in young subjects with fair skin. Sunbed use is now becoming more prevalent in Caucasian populations and the results of this study suggest that sunbed usage may moderately affect individuals with sun-sensitive skin types. However, the magnitude of melanoma risk in association with natural and artificial sun exposure is small compared with phenotypic risk factors such as skin type and naevus counts. However, it is possible that the mean lag time of 7 years between exposure to sunbed and melanoma in this study may have led to an under-estimation of the long-term melanoma risk.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Genetic Epidemiology and Twin Research Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK. veronique.bataille@cancer.org.uk

    , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Case-Control Studies
    Child
    Child, Preschool
    Female
    Heliotherapy
    Holidays
    Humans
    Infant
    Infant, Newborn
    London
    Male
    Melanoma
    Middle Aged
    Odds Ratio
    Risk Factors
    Skin Neoplasms
    Sunlight
    Time Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14746862

    Citation

    Bataille, V, et al. "Exposure to the Sun and Sunbeds and the Risk of Cutaneous Melanoma in the UK: a Case-control Study." European Journal of Cancer (Oxford, England : 1990), vol. 40, no. 3, 2004, pp. 429-35.
    Bataille V, Winnett A, Sasieni P, et al. Exposure to the sun and sunbeds and the risk of cutaneous melanoma in the UK: a case-control study. Eur J Cancer. 2004;40(3):429-35.
    Bataille, V., Winnett, A., Sasieni, P., Newton Bishop, J. A., & Cuzick, J. (2004). Exposure to the sun and sunbeds and the risk of cutaneous melanoma in the UK: a case-control study. European Journal of Cancer (Oxford, England : 1990), 40(3), pp. 429-35.
    Bataille V, et al. Exposure to the Sun and Sunbeds and the Risk of Cutaneous Melanoma in the UK: a Case-control Study. Eur J Cancer. 2004;40(3):429-35. PubMed PMID: 14746862.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Exposure to the sun and sunbeds and the risk of cutaneous melanoma in the UK: a case-control study. AU - Bataille,V, AU - Winnett,A, AU - Sasieni,P, AU - Newton Bishop,J A, AU - Cuzick,J, PY - 2004/1/30/pubmed PY - 2004/2/28/medline PY - 2004/1/30/entrez SP - 429 EP - 35 JF - European journal of cancer (Oxford, England : 1990) JO - Eur. J. Cancer VL - 40 IS - 3 N2 - Migration, latitude and case-control studies have clearly established a link between melanoma and sun exposure. This case-control study of melanoma was set up to examine the role of sun exposure and sunbeds in the pathogenesis of melanoma in the United Kingdom (UK), a country with low levels of ultraviolet radiation. The study included 413 cases and 416 controls. More than 10 severe sunburns compared with less than 10 sunburns was associated with an Odds Ratio (OR) of 1.98 (95% Confidence Interval (CI) 1.02-3.86) (P=0.04) when adjusted for age, gender and skin type. Sunburns before the age of 15 years were not associated with melanoma once adjustments for age, gender and skin were made. 31% of women and 16% of the men had used sunbeds. Sunbed users were younger than non-users (40 years versus 51 years, P<0.0001). Ever use of sunbeds gave an adjusted OR of 1.19 (95% CI 0.84-1.68) (P=0.33). The risk of melanoma did not increase with increasing hours or years of sunbed exposure. The risk associated with sunbed use was only significant for young individuals with fair skin for whom there was a significant OR of 2.66 (95% CI 1.66-6.09) (P=0.02) after adjustment for the sun exposure variables. Outdoor occupation and residence in hot countries were not associated with an increased risk of melanoma. The only significant associations in this study were with 10 or more sunburns and the use of a sunbed in young subjects with fair skin. Sunbed use is now becoming more prevalent in Caucasian populations and the results of this study suggest that sunbed usage may moderately affect individuals with sun-sensitive skin types. However, the magnitude of melanoma risk in association with natural and artificial sun exposure is small compared with phenotypic risk factors such as skin type and naevus counts. However, it is possible that the mean lag time of 7 years between exposure to sunbed and melanoma in this study may have led to an under-estimation of the long-term melanoma risk. SN - 0959-8049 UR - https://www.unboundmedicine.com/medline/citation/14746862/Exposure_to_the_sun_and_sunbeds_and_the_risk_of_cutaneous_melanoma_in_the_UK:_a_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S095980490300861X DB - PRIME DP - Unbound Medicine ER -