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Influence of a mineral water rich in calcium, magnesium and bicarbonate on urine composition and the risk of calcium oxalate crystallization.

Abstract

OBJECTIVE

To evaluate the effect of a mineral water rich in magnesium (337 mg/l), calcium (232 mg/l) and bicarbonate (3388 mg/l) on urine composition and the risk of calcium oxalate crystallization.

DESIGN

A total of 12 healthy male volunteers participated in the study. During the baseline phase, subjects collected two 24-h urine samples while on their usual diet. Throughout the control and test phases, lasting 5 days each, the subjects received a standardized diet calculated according to the recommendations. During the control phase, subjects consumed 1.4 l/day of a neutral fruit tea, which was replaced by an equal volume of a mineral water during the test phase. On the follow-up phase, subjects continued to drink 1.4 l/day of the mineral water on their usual diet and collected 24-h urine samples weekly.

RESULTS

During the intake of mineral water, urinary pH, magnesium and citrate excretion increased significantly on both standardized and normal dietary conditions. The mineral water led to a significant increase in urinary calcium excretion only on the standardized diet, and to a significantly higher urinary volume and decreased supersaturation with calcium oxalate only on the usual diet.

CONCLUSIONS

The magnesium and bicarbonate content of the mineral water resulted in favorable changes in urinary pH, magnesium and citrate excretion, inhibitors of calcium oxalate stone formation, counterbalancing increased calcium excretion. Since urinary oxalate excretion did not diminish, further studies are necessary to evaluate whether the ingestion of calcium-rich mineral water with, rather than between, meals may complex oxalate in the gut thus limiting intestinal absorption and urinary excretion of calcium and oxalate.

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  • Authors+Show Affiliations

    ,

    Division of Experimental Urology, Department of Urology, University of Bonn, Bonn, Germany. Roswitha.Siener@ukb.uni-bonn.de

    ,

    Source

    MeSH

    Adult
    Bicarbonates
    Calcium Oxalate
    Calcium, Dietary
    Circadian Rhythm
    Citric Acid
    Crystallization
    Humans
    Hydrogen-Ion Concentration
    Magnesium
    Male
    Mineral Waters
    Oxalic Acid
    Risk Factors

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    14749747

    Citation

    Siener, R, et al. "Influence of a Mineral Water Rich in Calcium, Magnesium and Bicarbonate On Urine Composition and the Risk of Calcium Oxalate Crystallization." European Journal of Clinical Nutrition, vol. 58, no. 2, 2004, pp. 270-6.
    Siener R, Jahnen A, Hesse A. Influence of a mineral water rich in calcium, magnesium and bicarbonate on urine composition and the risk of calcium oxalate crystallization. Eur J Clin Nutr. 2004;58(2):270-6.
    Siener, R., Jahnen, A., & Hesse, A. (2004). Influence of a mineral water rich in calcium, magnesium and bicarbonate on urine composition and the risk of calcium oxalate crystallization. European Journal of Clinical Nutrition, 58(2), pp. 270-6.
    Siener R, Jahnen A, Hesse A. Influence of a Mineral Water Rich in Calcium, Magnesium and Bicarbonate On Urine Composition and the Risk of Calcium Oxalate Crystallization. Eur J Clin Nutr. 2004;58(2):270-6. PubMed PMID: 14749747.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Influence of a mineral water rich in calcium, magnesium and bicarbonate on urine composition and the risk of calcium oxalate crystallization. AU - Siener,R, AU - Jahnen,A, AU - Hesse,A, PY - 2004/1/30/pubmed PY - 2004/4/20/medline PY - 2004/1/30/entrez SP - 270 EP - 6 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 58 IS - 2 N2 - OBJECTIVE: To evaluate the effect of a mineral water rich in magnesium (337 mg/l), calcium (232 mg/l) and bicarbonate (3388 mg/l) on urine composition and the risk of calcium oxalate crystallization. DESIGN: A total of 12 healthy male volunteers participated in the study. During the baseline phase, subjects collected two 24-h urine samples while on their usual diet. Throughout the control and test phases, lasting 5 days each, the subjects received a standardized diet calculated according to the recommendations. During the control phase, subjects consumed 1.4 l/day of a neutral fruit tea, which was replaced by an equal volume of a mineral water during the test phase. On the follow-up phase, subjects continued to drink 1.4 l/day of the mineral water on their usual diet and collected 24-h urine samples weekly. RESULTS: During the intake of mineral water, urinary pH, magnesium and citrate excretion increased significantly on both standardized and normal dietary conditions. The mineral water led to a significant increase in urinary calcium excretion only on the standardized diet, and to a significantly higher urinary volume and decreased supersaturation with calcium oxalate only on the usual diet. CONCLUSIONS: The magnesium and bicarbonate content of the mineral water resulted in favorable changes in urinary pH, magnesium and citrate excretion, inhibitors of calcium oxalate stone formation, counterbalancing increased calcium excretion. Since urinary oxalate excretion did not diminish, further studies are necessary to evaluate whether the ingestion of calcium-rich mineral water with, rather than between, meals may complex oxalate in the gut thus limiting intestinal absorption and urinary excretion of calcium and oxalate. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/14749747/Influence_of_a_mineral_water_rich_in_calcium_magnesium_and_bicarbonate_on_urine_composition_and_the_risk_of_calcium_oxalate_crystallization_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601778 DB - PRIME DP - Unbound Medicine ER -