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Mineral water fortified with folic acid, vitamins B6, B12, D and calcium improves folate status and decreases plasma homocysteine concentration in men and women.
Eur J Clin Nutr. 2004 Feb; 58(2):376-85.EJ

Abstract

OBJECTIVE

We investigated the effects of mineral water fortified with folic acid, vitamins B(6), B(12), D and calcium on folate concentrations in serum and erythrocytes, serum vitamin B(12) and plasma homocysteine concentrations in free-living subjects. In addition, we investigated the bioavailability of calcium added to mineral water by measuring urinary calcium excretion and serum alkaline phosphatase activity.

DESIGN

Randomized, controlled, double-blinded, parallel design.

SETTING

Outpatient dietary intervention with free-living subjects in Eastern Finland.

SUBJECTS

Altogether, 66 subjects were recruited for the study. In all, 60 subjects completed the study.

INTERVENTIONS

The study began with a 2-week run-in period followed by an 8-week intervention period. During the intervention study, subjects consumed mineral water fortified with folic acid (563 microg/day), vitamins B(6) (1 mg/day), B(12) (7.5 microg/day), cholecalciferol (0.6 microg/day) and calcium (563 mg/day) or placebo mineral water.

RESULTS

The fortified mineral water increased serum and erythrocyte folate concentrations by 16.1+/-5.6 nmol/l (P<0.001) and 199+/-76 nmol/l (P<0.001), respectively, and decreased plasma homocysteine concentration by 1.6 micromol/l (P<0.001). Urinary calcium excretion and serum alkaline phosphatase activity for 24 h increased significantly (P<0.001 and P=0.01 respectively) in the intervention group.

CONCLUSIONS

Mineral water fortified with folic acid, vitamins B(6), B(12) and D and calcium enhanced folate status and reduced plasma homocysteine concentration in normohomocysteinemic subjects without folate deficiency. Indirect measures of calcium and bone metabolism indicated that the calcium used in the fortification of the mineral water was bioavailable.

Authors+Show Affiliations

Contract research organization, Oy Foodfiles Ltd, Kuopio, Finland. niina.tapola@foodfiles.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14749760

Citation

Tapola, N S., et al. "Mineral Water Fortified With Folic Acid, Vitamins B6, B12, D and Calcium Improves Folate Status and Decreases Plasma Homocysteine Concentration in Men and Women." European Journal of Clinical Nutrition, vol. 58, no. 2, 2004, pp. 376-85.
Tapola NS, Karvonen HM, Niskanen LK, et al. Mineral water fortified with folic acid, vitamins B6, B12, D and calcium improves folate status and decreases plasma homocysteine concentration in men and women. Eur J Clin Nutr. 2004;58(2):376-85.
Tapola, N. S., Karvonen, H. M., Niskanen, L. K., & Sarkkinen, E. S. (2004). Mineral water fortified with folic acid, vitamins B6, B12, D and calcium improves folate status and decreases plasma homocysteine concentration in men and women. European Journal of Clinical Nutrition, 58(2), 376-85.
Tapola NS, et al. Mineral Water Fortified With Folic Acid, Vitamins B6, B12, D and Calcium Improves Folate Status and Decreases Plasma Homocysteine Concentration in Men and Women. Eur J Clin Nutr. 2004;58(2):376-85. PubMed PMID: 14749760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mineral water fortified with folic acid, vitamins B6, B12, D and calcium improves folate status and decreases plasma homocysteine concentration in men and women. AU - Tapola,N S, AU - Karvonen,H M, AU - Niskanen,L K, AU - Sarkkinen,E S, PY - 2004/1/30/pubmed PY - 2004/4/20/medline PY - 2004/1/30/entrez SP - 376 EP - 85 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 58 IS - 2 N2 - OBJECTIVE: We investigated the effects of mineral water fortified with folic acid, vitamins B(6), B(12), D and calcium on folate concentrations in serum and erythrocytes, serum vitamin B(12) and plasma homocysteine concentrations in free-living subjects. In addition, we investigated the bioavailability of calcium added to mineral water by measuring urinary calcium excretion and serum alkaline phosphatase activity. DESIGN: Randomized, controlled, double-blinded, parallel design. SETTING: Outpatient dietary intervention with free-living subjects in Eastern Finland. SUBJECTS: Altogether, 66 subjects were recruited for the study. In all, 60 subjects completed the study. INTERVENTIONS: The study began with a 2-week run-in period followed by an 8-week intervention period. During the intervention study, subjects consumed mineral water fortified with folic acid (563 microg/day), vitamins B(6) (1 mg/day), B(12) (7.5 microg/day), cholecalciferol (0.6 microg/day) and calcium (563 mg/day) or placebo mineral water. RESULTS: The fortified mineral water increased serum and erythrocyte folate concentrations by 16.1+/-5.6 nmol/l (P<0.001) and 199+/-76 nmol/l (P<0.001), respectively, and decreased plasma homocysteine concentration by 1.6 micromol/l (P<0.001). Urinary calcium excretion and serum alkaline phosphatase activity for 24 h increased significantly (P<0.001 and P=0.01 respectively) in the intervention group. CONCLUSIONS: Mineral water fortified with folic acid, vitamins B(6), B(12) and D and calcium enhanced folate status and reduced plasma homocysteine concentration in normohomocysteinemic subjects without folate deficiency. Indirect measures of calcium and bone metabolism indicated that the calcium used in the fortification of the mineral water was bioavailable. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/14749760/Mineral_water_fortified_with_folic_acid_vitamins_B6_B12_D_and_calcium_improves_folate_status_and_decreases_plasma_homocysteine_concentration_in_men_and_women_ L2 - https://doi.org/10.1038/sj.ejcn.1601795 DB - PRIME DP - Unbound Medicine ER -