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Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats.
Planta Med. 2003 Dec; 69(12):1075-9.PM

Abstract

The antihyperglycemic action of andrographolide, an active principle in the leaves of Andrographis paniculata (Burm. f.) Nees, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats). Oral treatment of andrographolide decreased the plasma glucose concentrations of STZ-diabetic rats in a dose-dependent manner. Similar treatment with andrographolide also decreased the plasma glucose in normal rats and the maximal effect was more marked than that in STZ-diabetic rats. Andrographolide at the effective dose (1.5 mg/kg) significantly attenuated the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. In the isolated soleus muscle of STZ-diabetic rats, andrographolide enhanced the uptake of radioactive glucose in a concentration-dependent manner. Moreover, the mRNA and protein levels of the subtype 4 form of the glucose transporter (GLUT4) in soleus muscle were increased after repeated intravenous administration of andrographolide in STZ-diabetic rats for 3 days. These results suggest that andrographolide can increase the glucose utilization to lower plasma glucose in diabetic rats lacking insulin.

Authors+Show Affiliations

Yu BC
Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan.
Hung CR
No affiliation info available
Chen WC
No affiliation info available
Cheng JT
No affiliation info available

MeSH

Administration, OralAndrographisAnimalsBlood GlucoseDiabetes Mellitus, ExperimentalDiterpenesDose-Response Relationship, DrugGlucoseGlucose Transporter Type 4Hypoglycemic AgentsMaleMonosaccharide Transport ProteinsMuscle ProteinsMuscle, SkeletalPhytotherapyPlant LeavesRNA, MessengerRatsRats, WistarStreptozocin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14750020

Citation

Yu, Bu-Chin, et al. "Antihyperglycemic Effect of Andrographolide in Streptozotocin-induced Diabetic Rats." Planta Medica, vol. 69, no. 12, 2003, pp. 1075-9.
Yu BC, Hung CR, Chen WC, et al. Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats. Planta Med. 2003;69(12):1075-9.
Yu, B. C., Hung, C. R., Chen, W. C., & Cheng, J. T. (2003). Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats. Planta Medica, 69(12), 1075-9.
Yu BC, et al. Antihyperglycemic Effect of Andrographolide in Streptozotocin-induced Diabetic Rats. Planta Med. 2003;69(12):1075-9. PubMed PMID: 14750020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats. AU - Yu,Bu-Chin, AU - Hung,Chen-Road, AU - Chen,Wang-Chuan, AU - Cheng,Juei-Tang, PY - 2004/1/30/pubmed PY - 2004/3/25/medline PY - 2004/1/30/entrez SP - 1075 EP - 9 JF - Planta medica JO - Planta Med VL - 69 IS - 12 N2 - The antihyperglycemic action of andrographolide, an active principle in the leaves of Andrographis paniculata (Burm. f.) Nees, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats). Oral treatment of andrographolide decreased the plasma glucose concentrations of STZ-diabetic rats in a dose-dependent manner. Similar treatment with andrographolide also decreased the plasma glucose in normal rats and the maximal effect was more marked than that in STZ-diabetic rats. Andrographolide at the effective dose (1.5 mg/kg) significantly attenuated the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. In the isolated soleus muscle of STZ-diabetic rats, andrographolide enhanced the uptake of radioactive glucose in a concentration-dependent manner. Moreover, the mRNA and protein levels of the subtype 4 form of the glucose transporter (GLUT4) in soleus muscle were increased after repeated intravenous administration of andrographolide in STZ-diabetic rats for 3 days. These results suggest that andrographolide can increase the glucose utilization to lower plasma glucose in diabetic rats lacking insulin. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/14750020/Antihyperglycemic_effect_of_andrographolide_in_streptozotocin_induced_diabetic_rats_ DB - PRIME DP - Unbound Medicine ER -