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Fibre intake and prostate cancer risk.
Int J Cancer 2004; 109(2):278-80IJ

Abstract

Dietary fibre has been reported to protect from several neoplasms, but the issue remains controversial. No previous study considered in depth the topic of fibres and prostate cancer. A multicentre case-control study was conducted in Italy from 1991 to 2002, including 1,294 men with incident, histologically confirmed prostate cancer and 1,451 controls admitted to the same network of hospitals as cases with acute nonmalignant conditions. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were obtained after allowance for major identified confounding factors, including total energy intake. Compared to the lowest quintile, the OR of prostate cancer for the highest quintile of total fibre intake was 0.93 (95% CI 0.71-1.22). The risk was inversely related with soluble fibre (OR = 0.89, 95% CI 0.78-1.02, for a difference between 80th and 20th percentile), cellulose (OR = 0.88, 95% CI 0.78-1.01) and vegetable fibre (OR = 0.82, 95% CI 0.73-0.93). These relationships were consistent across strata of age, family history of prostate cancer, body mass index and education. Vegetable fibres appear, therefore, to have a favourable association with prostate cancer risk.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. pelucchi@marionegri.it

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14750181

Citation

Pelucchi, Claudio, et al. "Fibre Intake and Prostate Cancer Risk." International Journal of Cancer, vol. 109, no. 2, 2004, pp. 278-80.
Pelucchi C, Talamini R, Galeone C, et al. Fibre intake and prostate cancer risk. Int J Cancer. 2004;109(2):278-80.
Pelucchi, C., Talamini, R., Galeone, C., Negri, E., Franceschi, S., Dal Maso, L., ... La Vecchia, C. (2004). Fibre intake and prostate cancer risk. International Journal of Cancer, 109(2), pp. 278-80.
Pelucchi C, et al. Fibre Intake and Prostate Cancer Risk. Int J Cancer. 2004 Mar 20;109(2):278-80. PubMed PMID: 14750181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fibre intake and prostate cancer risk. AU - Pelucchi,Claudio, AU - Talamini,Renato, AU - Galeone,Carlotta, AU - Negri,Eva, AU - Franceschi,Silvia, AU - Dal Maso,Luigino, AU - Montella,Maurizio, AU - Conti,Ettore, AU - La Vecchia,Carlo, PY - 2004/1/30/pubmed PY - 2004/3/18/medline PY - 2004/1/30/entrez SP - 278 EP - 80 JF - International journal of cancer JO - Int. J. Cancer VL - 109 IS - 2 N2 - Dietary fibre has been reported to protect from several neoplasms, but the issue remains controversial. No previous study considered in depth the topic of fibres and prostate cancer. A multicentre case-control study was conducted in Italy from 1991 to 2002, including 1,294 men with incident, histologically confirmed prostate cancer and 1,451 controls admitted to the same network of hospitals as cases with acute nonmalignant conditions. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were obtained after allowance for major identified confounding factors, including total energy intake. Compared to the lowest quintile, the OR of prostate cancer for the highest quintile of total fibre intake was 0.93 (95% CI 0.71-1.22). The risk was inversely related with soluble fibre (OR = 0.89, 95% CI 0.78-1.02, for a difference between 80th and 20th percentile), cellulose (OR = 0.88, 95% CI 0.78-1.01) and vegetable fibre (OR = 0.82, 95% CI 0.73-0.93). These relationships were consistent across strata of age, family history of prostate cancer, body mass index and education. Vegetable fibres appear, therefore, to have a favourable association with prostate cancer risk. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/14750181/Fibre_intake_and_prostate_cancer_risk_ L2 - https://doi.org/10.1002/ijc.11688 DB - PRIME DP - Unbound Medicine ER -