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[Assessment of serum levels of adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) in stable and unstable angina and acute myocardial infarction].
Przegl Lek 2003; 60(7):445-50PL

Abstract

The targeting and recruitment of inflammatory cells to vascular endothelium in ischaemic heart diseases is mediated by Intercellular Adhesion Molecule-1 (ICAM-1), Vascular Cell Adhesion Molecule (VCAM-1) and E-selectin and proinflammatory cytokines. Accumulation of mononuclear cells to the endothelium is one of the earliest events in the formation of an atherosclerotic lesion. The aim of this study was to estimate the serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), vascular adhesion molecule-1 (sVCAM-1), selectin E (sE-selectin) in patients with acute myocardial infarction (Group 1--n = 18 patients: 3 women and 15 men, mean age--60 years), unstable angina pectoris (Grupa 2--n = 31 patients: 8 women and 23 men, mean age--62 years and stable heart disease (Grupa 3--n = 25 patients: 14 women and 11 men, mean age--61 years. The control group (Group 4--n = 20) consist of twenty healthy patient without coronary risk factors. ELISA method was used to determine the concentration of adhesion molecules of acute inflammation parameters, and traditional risk factors with using standard methods. The serum levels of sICAM-1, sVCAM-1 were markedly elevated in patients with acute myocardial infarction, unstable angina pectoris and stable heart disease compared to control group (p < 0.001, p < 0.004, p < 0.0002 for sICAM-1, p < 0.007, p < 0.003, p < 0.004 for sVCAM-1). Serum concentration of sE-selectin in three groups was similar, we did not find statistically significant differences between them. Furthermore, serum concentrations of adhesion molecules correlated with serum concentrations of acute inflammation parameters and traditional coronary risk factor for example BMI, systolic and diastolic blood pressure and lipid concentration. Additional serum concentration of sICAM-1 was elevated in smoking patients compared to non-smokers. We conclude that evaluation of adhesion molecules (sICAM-1 and sVCAM-1 in patients with heart diseases can be unspecific markers of activity of inflammatory process in coronary vascular endothelium.

Authors+Show Affiliations

SP ZOZ MSW i A Oddział Kardiologil 15-950 Białystok, ul. Fabryczna 27. abossowski@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

14750416

Citation

Bossowska, Anna, et al. "[Assessment of Serum Levels of Adhesion Molecules (sICAM-1, sVCAM-1, sE-selectin) in Stable and Unstable Angina and Acute Myocardial Infarction]." Przeglad Lekarski, vol. 60, no. 7, 2003, pp. 445-50.
Bossowska A, Kiersnowska-Rogowska B, Bossowski A, et al. [Assessment of serum levels of adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) in stable and unstable angina and acute myocardial infarction]. Prz Lek. 2003;60(7):445-50.
Bossowska, A., Kiersnowska-Rogowska, B., Bossowski, A., Galar, B., & Sowiński, P. (2003). [Assessment of serum levels of adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) in stable and unstable angina and acute myocardial infarction]. Przeglad Lekarski, 60(7), pp. 445-50.
Bossowska A, et al. [Assessment of Serum Levels of Adhesion Molecules (sICAM-1, sVCAM-1, sE-selectin) in Stable and Unstable Angina and Acute Myocardial Infarction]. Prz Lek. 2003;60(7):445-50. PubMed PMID: 14750416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Assessment of serum levels of adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) in stable and unstable angina and acute myocardial infarction]. AU - Bossowska,Anna, AU - Kiersnowska-Rogowska,Beata, AU - Bossowski,Artur, AU - Galar,Bogdan, AU - Sowiński,Piotr, PY - 2004/1/31/pubmed PY - 2004/4/24/medline PY - 2004/1/31/entrez SP - 445 EP - 50 JF - Przeglad lekarski JO - Prz. Lek. VL - 60 IS - 7 N2 - The targeting and recruitment of inflammatory cells to vascular endothelium in ischaemic heart diseases is mediated by Intercellular Adhesion Molecule-1 (ICAM-1), Vascular Cell Adhesion Molecule (VCAM-1) and E-selectin and proinflammatory cytokines. Accumulation of mononuclear cells to the endothelium is one of the earliest events in the formation of an atherosclerotic lesion. The aim of this study was to estimate the serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), vascular adhesion molecule-1 (sVCAM-1), selectin E (sE-selectin) in patients with acute myocardial infarction (Group 1--n = 18 patients: 3 women and 15 men, mean age--60 years), unstable angina pectoris (Grupa 2--n = 31 patients: 8 women and 23 men, mean age--62 years and stable heart disease (Grupa 3--n = 25 patients: 14 women and 11 men, mean age--61 years. The control group (Group 4--n = 20) consist of twenty healthy patient without coronary risk factors. ELISA method was used to determine the concentration of adhesion molecules of acute inflammation parameters, and traditional risk factors with using standard methods. The serum levels of sICAM-1, sVCAM-1 were markedly elevated in patients with acute myocardial infarction, unstable angina pectoris and stable heart disease compared to control group (p < 0.001, p < 0.004, p < 0.0002 for sICAM-1, p < 0.007, p < 0.003, p < 0.004 for sVCAM-1). Serum concentration of sE-selectin in three groups was similar, we did not find statistically significant differences between them. Furthermore, serum concentrations of adhesion molecules correlated with serum concentrations of acute inflammation parameters and traditional coronary risk factor for example BMI, systolic and diastolic blood pressure and lipid concentration. Additional serum concentration of sICAM-1 was elevated in smoking patients compared to non-smokers. We conclude that evaluation of adhesion molecules (sICAM-1 and sVCAM-1 in patients with heart diseases can be unspecific markers of activity of inflammatory process in coronary vascular endothelium. SN - 0033-2240 UR - https://www.unboundmedicine.com/medline/citation/14750416/[Assessment_of_serum_levels_of_adhesion_molecules__sICAM_1_sVCAM_1_sE_selectin__in_stable_and_unstable_angina_and_acute_myocardial_infarction]_ L2 - http://www.diseaseinfosearch.org/result/8938 DB - PRIME DP - Unbound Medicine ER -