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Effects of hypoxia on the brain: neuroimaging and neuropsychological findings following carbon monoxide poisoning and obstructive sleep apnea.
J Int Neuropsychol Soc 2004; 10(1):60-71JI

Abstract

Hypoxia damages multiple organ systems especially those with high oxygen utilization such as the central nervous system. The purpose of this study was to compare the neuropathological and neuropsychological effects of hypoxia in patients with either carbon monoxide poisoning or obstructive sleep apnea. Neuroimaging revealed evidence of hippocampal atrophy in both groups although a linear relationship between hippocampal volume and memory performance was found only for selected tests and only in the sleep apnea group. There were significant correlations between hippocampal volume and performance on measures related to nonverbal/information processing. Generalized brain atrophy, as measured by the ventricle-to-brain ratio, was more common in the carbon monoxide poisoning group compared to the obstructive sleep apnea group. Performance on tests of executive function improved following treatment with nasal continuous positive airway pressure treatment in the obstructive sleep apnea group but there was no associated improvement in general intellectual function. We found that hypoxia due to obstructive sleep apnea and CO poisoning resulted in neuropathological changes and neuropsychological impairments. The observed group differences provide insight into the relationship between etiology of injury, neuropathological changes, and clinical presentation.

Authors+Show Affiliations

Department of Clinical Neuropsychology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, USA. s2gale@chw.eduNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14751008

Citation

Gale, Shawn D., and Ramona O. Hopkins. "Effects of Hypoxia On the Brain: Neuroimaging and Neuropsychological Findings Following Carbon Monoxide Poisoning and Obstructive Sleep Apnea." Journal of the International Neuropsychological Society : JINS, vol. 10, no. 1, 2004, pp. 60-71.
Gale SD, Hopkins RO. Effects of hypoxia on the brain: neuroimaging and neuropsychological findings following carbon monoxide poisoning and obstructive sleep apnea. J Int Neuropsychol Soc. 2004;10(1):60-71.
Gale, S. D., & Hopkins, R. O. (2004). Effects of hypoxia on the brain: neuroimaging and neuropsychological findings following carbon monoxide poisoning and obstructive sleep apnea. Journal of the International Neuropsychological Society : JINS, 10(1), pp. 60-71.
Gale SD, Hopkins RO. Effects of Hypoxia On the Brain: Neuroimaging and Neuropsychological Findings Following Carbon Monoxide Poisoning and Obstructive Sleep Apnea. J Int Neuropsychol Soc. 2004;10(1):60-71. PubMed PMID: 14751008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of hypoxia on the brain: neuroimaging and neuropsychological findings following carbon monoxide poisoning and obstructive sleep apnea. AU - Gale,Shawn D, AU - Hopkins,Ramona O, PY - 2002/01/04/received PY - 2003/04/09/revised PY - 2004/1/31/pubmed PY - 2004/3/9/medline PY - 2004/1/31/entrez SP - 60 EP - 71 JF - Journal of the International Neuropsychological Society : JINS JO - J Int Neuropsychol Soc VL - 10 IS - 1 N2 - Hypoxia damages multiple organ systems especially those with high oxygen utilization such as the central nervous system. The purpose of this study was to compare the neuropathological and neuropsychological effects of hypoxia in patients with either carbon monoxide poisoning or obstructive sleep apnea. Neuroimaging revealed evidence of hippocampal atrophy in both groups although a linear relationship between hippocampal volume and memory performance was found only for selected tests and only in the sleep apnea group. There were significant correlations between hippocampal volume and performance on measures related to nonverbal/information processing. Generalized brain atrophy, as measured by the ventricle-to-brain ratio, was more common in the carbon monoxide poisoning group compared to the obstructive sleep apnea group. Performance on tests of executive function improved following treatment with nasal continuous positive airway pressure treatment in the obstructive sleep apnea group but there was no associated improvement in general intellectual function. We found that hypoxia due to obstructive sleep apnea and CO poisoning resulted in neuropathological changes and neuropsychological impairments. The observed group differences provide insight into the relationship between etiology of injury, neuropathological changes, and clinical presentation. SN - 1355-6177 UR - https://www.unboundmedicine.com/medline/citation/14751008/Effects_of_hypoxia_on_the_brain:_neuroimaging_and_neuropsychological_findings_following_carbon_monoxide_poisoning_and_obstructive_sleep_apnea_ L2 - https://www.cambridge.org/core/product/identifier/S1355617704101082/type/journal_article DB - PRIME DP - Unbound Medicine ER -