Tags

Type your tag names separated by a space and hit enter

Changes in urinary parameters after oral administration of potassium-sodium citrate and magnesium oxide to prevent urolithiasis.
Urology 2004; 63(1):7-11; discussion 11-2U

Abstract

OBJECTIVES

To examine urinary parameters among normal individuals and patients with calcium oxalate (CaOx) stones after oral administration of potassium-sodium citrate (KNa-Cit) and magnesium oxide (MgO). Urinary citrate and magnesium have been known as the inhibitors of CaOx stone formation. Supplementation with potassium-magnesium citrate prevents the recurrence of CaOx stones.

METHODS

Twenty-five male volunteers aged 21 to 42 years without a history of urinary stones were given either KNa-Cit or MgO, or both. Fourteen patients with recurrent CaOx stones were also given both supplements, and 24-hour urine samples were collected to determine the urinary parameters.

RESULTS

The administration of both KNa-Cit and MgO to the normal individuals increased the excretion of citrate, magnesium, and potassium by 70.0%, 44.2%, and 50.0%, respectively. These parameters increased less when KNa-Cit or MgO was administered individually. After administration of both supplements to the patients with stones, the citrate, magnesium, and potassium levels increased by 62.1%, 63.3%, and 25.3%, respectively, and oxalate decreased by 66.5%. In both normal individuals and patients, the ion activity product index of CaOx decreased significantly more after administration of the combination than with either compound alone or before administration.

CONCLUSION

The combination of KNa-Cit and MgO is more effective than either supplement alone in inhibiting the crystallization of CaOx stones. The combination may improve the urinary parameters of patients with stones accompanied by hypocitraturia and/or hypomagnesuria.

Authors+Show Affiliations

Department of Urology, Asahikawa Medical College, Asahikawa, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

14751336

Citation

Kato, Yuji, et al. "Changes in Urinary Parameters After Oral Administration of Potassium-sodium Citrate and Magnesium Oxide to Prevent Urolithiasis." Urology, vol. 63, no. 1, 2004, pp. 7-11; discussion 11-2.
Kato Y, Yamaguchi S, Yachiku S, et al. Changes in urinary parameters after oral administration of potassium-sodium citrate and magnesium oxide to prevent urolithiasis. Urology. 2004;63(1):7-11; discussion 11-2.
Kato, Y., Yamaguchi, S., Yachiku, S., Nakazono, S., Hori, J., Wada, N., & Hou, K. (2004). Changes in urinary parameters after oral administration of potassium-sodium citrate and magnesium oxide to prevent urolithiasis. Urology, 63(1), pp. 7-11; discussion 11-2.
Kato Y, et al. Changes in Urinary Parameters After Oral Administration of Potassium-sodium Citrate and Magnesium Oxide to Prevent Urolithiasis. Urology. 2004;63(1):7-11; discussion 11-2. PubMed PMID: 14751336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in urinary parameters after oral administration of potassium-sodium citrate and magnesium oxide to prevent urolithiasis. AU - Kato,Yuji, AU - Yamaguchi,Satoshi, AU - Yachiku,Sunao, AU - Nakazono,Shusaku, AU - Hori,Jun-ichi, AU - Wada,Naoki, AU - Hou,Kyokushin, PY - 2004/1/31/pubmed PY - 2004/6/2/medline PY - 2004/1/31/entrez SP - 7-11; discussion 11-2 JF - Urology JO - Urology VL - 63 IS - 1 N2 - OBJECTIVES: To examine urinary parameters among normal individuals and patients with calcium oxalate (CaOx) stones after oral administration of potassium-sodium citrate (KNa-Cit) and magnesium oxide (MgO). Urinary citrate and magnesium have been known as the inhibitors of CaOx stone formation. Supplementation with potassium-magnesium citrate prevents the recurrence of CaOx stones. METHODS: Twenty-five male volunteers aged 21 to 42 years without a history of urinary stones were given either KNa-Cit or MgO, or both. Fourteen patients with recurrent CaOx stones were also given both supplements, and 24-hour urine samples were collected to determine the urinary parameters. RESULTS: The administration of both KNa-Cit and MgO to the normal individuals increased the excretion of citrate, magnesium, and potassium by 70.0%, 44.2%, and 50.0%, respectively. These parameters increased less when KNa-Cit or MgO was administered individually. After administration of both supplements to the patients with stones, the citrate, magnesium, and potassium levels increased by 62.1%, 63.3%, and 25.3%, respectively, and oxalate decreased by 66.5%. In both normal individuals and patients, the ion activity product index of CaOx decreased significantly more after administration of the combination than with either compound alone or before administration. CONCLUSION: The combination of KNa-Cit and MgO is more effective than either supplement alone in inhibiting the crystallization of CaOx stones. The combination may improve the urinary parameters of patients with stones accompanied by hypocitraturia and/or hypomagnesuria. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/14751336/Changes_in_urinary_parameters_after_oral_administration_of_potassium_sodium_citrate_and_magnesium_oxide_to_prevent_urolithiasis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090429503010628 DB - PRIME DP - Unbound Medicine ER -