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Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study.
Bone 2004; 34(1):195-202BONE

Abstract

The incidence of all non-vertebral fractures, as well as the relation to bone mineral density (BMD), was quantified in 7806 men and women from the Rotterdam Study, a prospective, population-based cohort study of men and women aged 55 years and older. In addition, the sensitivity of using a T-score at or below -2.5 for identifying subjects at risk for fractures was assessed. At baseline, between 1990 and 1993, femoral neck BMD was measured by dual energy X-ray absorptiometry (DXA). Subsequently, gender-specific T-scores were calculated using the NHANES reference population. During a mean follow-up of 6.8 years, information on incident non-vertebral fractures was gathered. In general, hip, wrist and upper humerus fractures are the most frequent fractures in both men and women. Femoral neck BMD appears to be an equally important risk factor in both genders, and is especially related to hip fractures. For all non-vertebral fractures, the age-adjusted hazard ratio (95% confidence interval) per standard deviation decrease in femoral neck BMD was 1.5 (1.4-1.6) for women and 1.4 (1.2-1.6) for men. For hip fractures, the hazard ratios were 2.1 (1.7-2.5) for women and 2.3 (1.6-3.3) for men. Only 44% of all non-vertebral fractures occurred in women with a T-score below -2.5; in men, this percentage was even lower (21%). Thus, there is a clear need for the development of more sensitive risk assessment tools, using not only BMD, but also other clinical predictors of fractures.

Authors+Show Affiliations

Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14751578

Citation

Schuit, S C E., et al. "Fracture Incidence and Association With Bone Mineral Density in Elderly Men and Women: the Rotterdam Study." Bone, vol. 34, no. 1, 2004, pp. 195-202.
Schuit SC, van der Klift M, Weel AE, et al. Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone. 2004;34(1):195-202.
Schuit, S. C., van der Klift, M., Weel, A. E., de Laet, C. E., Burger, H., Seeman, E., ... Pols, H. A. (2004). Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone, 34(1), pp. 195-202.
Schuit SC, et al. Fracture Incidence and Association With Bone Mineral Density in Elderly Men and Women: the Rotterdam Study. Bone. 2004;34(1):195-202. PubMed PMID: 14751578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. AU - Schuit,S C E, AU - van der Klift,M, AU - Weel,A E A M, AU - de Laet,C E D H, AU - Burger,H, AU - Seeman,E, AU - Hofman,A, AU - Uitterlinden,A G, AU - van Leeuwen,J P T M, AU - Pols,H A P, PY - 2004/1/31/pubmed PY - 2004/9/16/medline PY - 2004/1/31/entrez SP - 195 EP - 202 JF - Bone JO - Bone VL - 34 IS - 1 N2 - The incidence of all non-vertebral fractures, as well as the relation to bone mineral density (BMD), was quantified in 7806 men and women from the Rotterdam Study, a prospective, population-based cohort study of men and women aged 55 years and older. In addition, the sensitivity of using a T-score at or below -2.5 for identifying subjects at risk for fractures was assessed. At baseline, between 1990 and 1993, femoral neck BMD was measured by dual energy X-ray absorptiometry (DXA). Subsequently, gender-specific T-scores were calculated using the NHANES reference population. During a mean follow-up of 6.8 years, information on incident non-vertebral fractures was gathered. In general, hip, wrist and upper humerus fractures are the most frequent fractures in both men and women. Femoral neck BMD appears to be an equally important risk factor in both genders, and is especially related to hip fractures. For all non-vertebral fractures, the age-adjusted hazard ratio (95% confidence interval) per standard deviation decrease in femoral neck BMD was 1.5 (1.4-1.6) for women and 1.4 (1.2-1.6) for men. For hip fractures, the hazard ratios were 2.1 (1.7-2.5) for women and 2.3 (1.6-3.3) for men. Only 44% of all non-vertebral fractures occurred in women with a T-score below -2.5; in men, this percentage was even lower (21%). Thus, there is a clear need for the development of more sensitive risk assessment tools, using not only BMD, but also other clinical predictors of fractures. SN - 8756-3282 UR - https://www.unboundmedicine.com/medline/citation/14751578/Fracture_incidence_and_association_with_bone_mineral_density_in_elderly_men_and_women:_the_Rotterdam_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S8756328203003776 DB - PRIME DP - Unbound Medicine ER -