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Effect of sodium loading (3% NaCl) on arachidonic acid biosynthesis in rat liver microsomes.

Abstract

Sodium loading increases arachidonic acid (AA) metabolism by way of the prostaglandins(PGs) from series 2. Its effect on AA biosynthesis remains unknown. The purpose of the present study was to investigate the influence of sodium loading on the fatty acid composition of liver and liver microsomes, and the liver microsomal delta-6 and delta-5 desaturations of linoleic acid (LA) into AA. We found a decrease of LA and dihomo-gamma-linolenic acid (DGLA) levels in liver total lipids of Wistar rats receiving hypernatriuretic drinking water (NaCl 3%) for 60 days. At the same time AA increased. DGLA decreased and AA increased in liver microsomal total lipids. 1(14) C-LA delta-6 desaturase and 2(14) C-DGLA delta-5 desaturase activities increased in liver microsomes. These results show that, in addition to its influence on the regulation of glomerular filtration, sodium loading is involved in the regulation of liver AA biosynthesis.

Authors+Show Affiliations

Unité de Recherche de Nutrition Cellulaire et Métabolique, Université de Bourgogne, Dijon, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1475274

Citation

Narce, M, et al. "Effect of Sodium Loading (3% NaCl) On Arachidonic Acid Biosynthesis in Rat Liver Microsomes." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 47, no. 3, 1992, pp. 193-7.
Narce M, Mimouni V, Poisson JP. Effect of sodium loading (3% NaCl) on arachidonic acid biosynthesis in rat liver microsomes. Prostaglandins Leukot Essent Fatty Acids. 1992;47(3):193-7.
Narce, M., Mimouni, V., & Poisson, J. P. (1992). Effect of sodium loading (3% NaCl) on arachidonic acid biosynthesis in rat liver microsomes. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 47(3), 193-7.
Narce M, Mimouni V, Poisson JP. Effect of Sodium Loading (3% NaCl) On Arachidonic Acid Biosynthesis in Rat Liver Microsomes. Prostaglandins Leukot Essent Fatty Acids. 1992;47(3):193-7. PubMed PMID: 1475274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of sodium loading (3% NaCl) on arachidonic acid biosynthesis in rat liver microsomes. AU - Narce,M, AU - Mimouni,V, AU - Poisson,J P, PY - 1992/11/1/pubmed PY - 1992/11/1/medline PY - 1992/11/1/entrez SP - 193 EP - 7 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 47 IS - 3 N2 - Sodium loading increases arachidonic acid (AA) metabolism by way of the prostaglandins(PGs) from series 2. Its effect on AA biosynthesis remains unknown. The purpose of the present study was to investigate the influence of sodium loading on the fatty acid composition of liver and liver microsomes, and the liver microsomal delta-6 and delta-5 desaturations of linoleic acid (LA) into AA. We found a decrease of LA and dihomo-gamma-linolenic acid (DGLA) levels in liver total lipids of Wistar rats receiving hypernatriuretic drinking water (NaCl 3%) for 60 days. At the same time AA increased. DGLA decreased and AA increased in liver microsomal total lipids. 1(14) C-LA delta-6 desaturase and 2(14) C-DGLA delta-5 desaturase activities increased in liver microsomes. These results show that, in addition to its influence on the regulation of glomerular filtration, sodium loading is involved in the regulation of liver AA biosynthesis. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/1475274/Effect_of_sodium_loading__3_NaCl__on_arachidonic_acid_biosynthesis_in_rat_liver_microsomes_ DB - PRIME DP - Unbound Medicine ER -