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Beta-adrenergic blockers reduce the risk of fracture partly by increasing bone mineral density: Geelong Osteoporosis Study.
J Bone Miner Res 2004; 19(1):19-24JB

Abstract

This population-based study documented beta-blocker use in 59/569 cases with incident fracture and 112/775 controls. OR for fracture associated with beta-blocker use was 0.68 (95%CI, 0.49-0.96). Beta-blockers were associated with higher BMD at the total hip (2.5%) and UD forearm (3.6%) after adjusting for age, anthropometry, and thiazide use. Beta-blocker use is associated with reduced fracture risk and higher BMD.

INTRODUCTION

Animal data suggests that bone formation is under beta-adrenergic control and that beta-blockers stimulate bone formation and/or inhibit bone resorption.

MATERIALS AND METHODS

We evaluated the association between beta-blocker use, bone mineral density (BMD), and fracture risk in a population-based study in Geelong, a southeastern Australian city with a single teaching hospital and two radiological centers providing complete fracture ascertainment for the region. Beta-blocker use was documented for 569 women with radiologically confirmed incident fractures and 775 controls without incident fracture. Medication use and lifestyle factors were documented by questionnaire.

RESULTS

Odds ratio for fracture associated with beta-blocker use was 0.68 (95% CI, 0.49-0.96) for any fracture. Adjusting for age, weight, medications, and lifestyle factors had little effect on the odds ratio. Beta-blocker use was associated with a higher BMD at the total hip (2.5%, p = 0.03) and ultradistal forearm (3.6%, p = 0.04) after adjustment for age, anthropometry, and thiazide use.

CONCLUSION

Beta-blockers are associated with a reduction in fracture risk and higher BMD.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Pasco JA
    Department of Clinical and Biomedical Sciences: Barwon Health, The University of Melbourne, Geelong, Australia. juliep@barwonhealth.org.au
    Henry MJ
    No affiliation info available
    Sanders KM
    No affiliation info available
    Kotowicz MA
    No affiliation info available
    Seeman E
    No affiliation info available
    Nicholson GC
    No affiliation info available
    Geelong Osteoporosis Study
    No affiliation info available

    MeSH

    Adrenergic beta-AntagonistsAgedAnthropometryAustraliaBone DensityBone and BonesBones of Upper ExtremityCardiovascular DiseasesCase-Control StudiesFemaleFemurFemur NeckFractures, BoneHumansLumbar VertebraeMiddle AgedOdds RatioRegression AnalysisSurveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14753732

    Citation

    Pasco, Julie A., et al. "Beta-adrenergic Blockers Reduce the Risk of Fracture Partly By Increasing Bone Mineral Density: Geelong Osteoporosis Study." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 19, no. 1, 2004, pp. 19-24.
    Pasco JA, Henry MJ, Sanders KM, et al. Beta-adrenergic blockers reduce the risk of fracture partly by increasing bone mineral density: Geelong Osteoporosis Study. J Bone Miner Res. 2004;19(1):19-24.
    Pasco, J. A., Henry, M. J., Sanders, K. M., Kotowicz, M. A., Seeman, E., & Nicholson, G. C. (2004). Beta-adrenergic blockers reduce the risk of fracture partly by increasing bone mineral density: Geelong Osteoporosis Study. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 19(1), pp. 19-24.
    Pasco JA, et al. Beta-adrenergic Blockers Reduce the Risk of Fracture Partly By Increasing Bone Mineral Density: Geelong Osteoporosis Study. J Bone Miner Res. 2004;19(1):19-24. PubMed PMID: 14753732.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Beta-adrenergic blockers reduce the risk of fracture partly by increasing bone mineral density: Geelong Osteoporosis Study. AU - Pasco,Julie A, AU - Henry,Margaret J, AU - Sanders,Kerrie M, AU - Kotowicz,Mark A, AU - Seeman,Ego, AU - Nicholson,Geoffrey C, AU - ,, PY - 2004/2/3/pubmed PY - 2004/10/7/medline PY - 2004/2/3/entrez SP - 19 EP - 24 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 19 IS - 1 N2 - UNLABELLED: This population-based study documented beta-blocker use in 59/569 cases with incident fracture and 112/775 controls. OR for fracture associated with beta-blocker use was 0.68 (95%CI, 0.49-0.96). Beta-blockers were associated with higher BMD at the total hip (2.5%) and UD forearm (3.6%) after adjusting for age, anthropometry, and thiazide use. Beta-blocker use is associated with reduced fracture risk and higher BMD. INTRODUCTION: Animal data suggests that bone formation is under beta-adrenergic control and that beta-blockers stimulate bone formation and/or inhibit bone resorption. MATERIALS AND METHODS: We evaluated the association between beta-blocker use, bone mineral density (BMD), and fracture risk in a population-based study in Geelong, a southeastern Australian city with a single teaching hospital and two radiological centers providing complete fracture ascertainment for the region. Beta-blocker use was documented for 569 women with radiologically confirmed incident fractures and 775 controls without incident fracture. Medication use and lifestyle factors were documented by questionnaire. RESULTS: Odds ratio for fracture associated with beta-blocker use was 0.68 (95% CI, 0.49-0.96) for any fracture. Adjusting for age, weight, medications, and lifestyle factors had little effect on the odds ratio. Beta-blocker use was associated with a higher BMD at the total hip (2.5%, p = 0.03) and ultradistal forearm (3.6%, p = 0.04) after adjustment for age, anthropometry, and thiazide use. CONCLUSION: Beta-blockers are associated with a reduction in fracture risk and higher BMD. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/14753732/Beta_adrenergic_blockers_reduce_the_risk_of_fracture_partly_by_increasing_bone_mineral_density:_Geelong_Osteoporosis_Study_ L2 - https://doi.org/10.1359/JBMR.0301214 DB - PRIME DP - Unbound Medicine ER -