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Umbilical venous IGF-1 concentration, neonatal bone mass, and body composition.
J Bone Miner Res 2004; 19(1):56-63JB

Abstract

IGF-1 is a key growth factor during fetal life. Using DXA, we found that the concentration of IGF-1 in umbilical cord serum is strongly related to neonatal whole body bone mineral content, lean mass, and fat mass. However IGF-1 did not explain the relationships of maternal smoking, fat mass, and physical activity with neonatal bone mass. The study supports a direct role for circulating IGF-1 in growth of the fetal skeleton.

INTRODUCTION

Evidence is accumulating that the risk of osteoporosis in later life may be determined in part by environmental influences during intrauterine and early postnatal life. We previously reported that maternal birthweight, smoking, fat stores, and physical activity during pregnancy predict neonatal bone mass. While the growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis is an important determinant of postnatal skeletal growth, there are few data relating the concentration of growth factors in umbilical cord blood to bone mineral content (BMC) and other indices of body composition in the newborn infant.

MATERIALS AND METHODS

We conducted a population-based study in a cohort of full-term, newborn infants whose mothers were characterized for lifestyle, body composition, and nutrition through their normal pregnancies. In a sample of 119 infants from the cohort, we related cord serum IGF-1 and insulin-like growth factor binding protein (IGFBP)-3 concentrations to neonatal body composition measured by DXA and evaluated the extent to which this cytokine mediates the previously reported effects of maternal diet and lifestyle on neonatal bone mass.

RESULTS

There were strong positive associations between cord serum IGF-1 concentration and whole body BMC (r = 0.38, p < 0.001), whole body lean mass (r = 0.40, p < 0.001), and whole body fat mass (r = 0.50, p < 0.001) after adjusting for gestational age and sex. There was no association between cord serum IGF-1 and BMC adjusted for bone size. Neither cord serum IGF-1 nor IGFBP-3 explained the relationships that we previously reported between maternal influences and neonatal bone mass.

CONCLUSIONS

Cord serum IGF-1 is more closely related to the size of the neonatal skeleton than to its degree of mineralization. Documented maternal determinants of neonatal bone mass seem to mediate their effects independently of variations in cord serum IGF-1 in healthy pregnancies.

Authors+Show Affiliations

MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14753737

Citation

Javaid, M K., et al. "Umbilical Venous IGF-1 Concentration, Neonatal Bone Mass, and Body Composition." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 19, no. 1, 2004, pp. 56-63.
Javaid MK, Godfrey KM, Taylor P, et al. Umbilical venous IGF-1 concentration, neonatal bone mass, and body composition. J Bone Miner Res. 2004;19(1):56-63.
Javaid, M. K., Godfrey, K. M., Taylor, P., Shore, S. R., Breier, B., Arden, N. K., & Cooper, C. (2004). Umbilical venous IGF-1 concentration, neonatal bone mass, and body composition. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 19(1), pp. 56-63.
Javaid MK, et al. Umbilical Venous IGF-1 Concentration, Neonatal Bone Mass, and Body Composition. J Bone Miner Res. 2004;19(1):56-63. PubMed PMID: 14753737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Umbilical venous IGF-1 concentration, neonatal bone mass, and body composition. AU - Javaid,M K, AU - Godfrey,K M, AU - Taylor,P, AU - Shore,S R, AU - Breier,B, AU - Arden,N K, AU - Cooper,C, PY - 2004/2/3/pubmed PY - 2004/10/7/medline PY - 2004/2/3/entrez SP - 56 EP - 63 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 19 IS - 1 N2 - UNLABELLED: IGF-1 is a key growth factor during fetal life. Using DXA, we found that the concentration of IGF-1 in umbilical cord serum is strongly related to neonatal whole body bone mineral content, lean mass, and fat mass. However IGF-1 did not explain the relationships of maternal smoking, fat mass, and physical activity with neonatal bone mass. The study supports a direct role for circulating IGF-1 in growth of the fetal skeleton. INTRODUCTION: Evidence is accumulating that the risk of osteoporosis in later life may be determined in part by environmental influences during intrauterine and early postnatal life. We previously reported that maternal birthweight, smoking, fat stores, and physical activity during pregnancy predict neonatal bone mass. While the growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis is an important determinant of postnatal skeletal growth, there are few data relating the concentration of growth factors in umbilical cord blood to bone mineral content (BMC) and other indices of body composition in the newborn infant. MATERIALS AND METHODS: We conducted a population-based study in a cohort of full-term, newborn infants whose mothers were characterized for lifestyle, body composition, and nutrition through their normal pregnancies. In a sample of 119 infants from the cohort, we related cord serum IGF-1 and insulin-like growth factor binding protein (IGFBP)-3 concentrations to neonatal body composition measured by DXA and evaluated the extent to which this cytokine mediates the previously reported effects of maternal diet and lifestyle on neonatal bone mass. RESULTS: There were strong positive associations between cord serum IGF-1 concentration and whole body BMC (r = 0.38, p < 0.001), whole body lean mass (r = 0.40, p < 0.001), and whole body fat mass (r = 0.50, p < 0.001) after adjusting for gestational age and sex. There was no association between cord serum IGF-1 and BMC adjusted for bone size. Neither cord serum IGF-1 nor IGFBP-3 explained the relationships that we previously reported between maternal influences and neonatal bone mass. CONCLUSIONS: Cord serum IGF-1 is more closely related to the size of the neonatal skeleton than to its degree of mineralization. Documented maternal determinants of neonatal bone mass seem to mediate their effects independently of variations in cord serum IGF-1 in healthy pregnancies. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/14753737/Umbilical_venous_IGF_1_concentration_neonatal_bone_mass_and_body_composition_ L2 - https://doi.org/10.1359/JBMR.0301211 DB - PRIME DP - Unbound Medicine ER -